ALLOBARBITAL Property

Melting point:

171-173°

Boiling point:

347.41°C (rough estimate)

Density 

1.2420 (rough estimate)

refractive index 

1.4830 (estimate)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

7.67±0.10(Predicted)

color 

White to Orange

Water Solubility 

1.77g/L(25 ºC)

EPA Substance Registry System

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-di-2-propen-1-yl- (52-43-7)

Safety

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

CQ3325000

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 i.p. in rats: 127.3 mg/kg (Sandberg)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

ALLOBARBITAL Chemical Properties,Usage,Production

Originator

Allobarbital, Fluorochem Ltd.

Uses

Allobarbital is a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance.

Definition

ChEBI: Allobarbital is a member of barbiturates.

Manufacturing Process

To a mixture of 43 parts barbituric acid, 200 parts of water and 5 parts of cuprous sulfate in 10 parts of water is added 82 parts of allylbromide. Then at room temperature is added 27 parts of sodium hydroxide (10% aqueous solution). 5,5-Diallylbarbituric acid is isolated by filtration. After recrystallization from water 5,5-diallylbarbituric acid has melting polint 169- 170°C.

Therapeutic Function

Sedative, Hypnotic