KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE

Product Name: KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
CAS No.: 58002-62-3
Chemical Name: KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
Synonyms: KAINIC ACID MONOHYDRATE;KAINIC ACID HYDRATE;(?)-(α)-Kainic Acid hydrate;(-)-KAINIC ACID, MONOHYDRATE;(-)-α-Kainic Acid Monohydrate;(-)-(α)-Kainic Acid (hydrate);KAINIC ACID MONOHYDRATE, ISOLATED FROM D;kainic acid monohydrate from digenea simplex;2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE;(2S,3S,4S)-2-CARBOXY-4-ISOPROPENYL-3-PYRROLIDINEACETIC ACID
CBNumber: CB5351307
Molecular Formula: C10H17NO5
Formula Weight: 231.25
MOL File: 58002-62-3.mol

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KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Property

Melting point:: 250-252°C
RTECS: UX9665250
storage temp.: 2-8°C
solubility: H₂O: >10 mg/mL
form: solid
color: white
Sensitive: Light Sensitive

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10
TSCA: No

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: K0250
Product name: Kainic acid monohydrate
Purity: ≥99% (TLC)
Packaging: 10mg
Price: $261
Updated: 2024/03/01

Sigma-Aldrich

Product number: K0250
Product name: Kainic acid monohydrate
Purity: ≥99% (TLC)
Packaging: 50mg
Price: $1150
Updated: 2024/03/01

Alfa Aesar

Product number: J66590
Product name: Kainic acid monohydrate, 98%
Packaging: 10mg
Price: $177
Updated: 2023/06/20

Cayman Chemical

Product number: 78050
Product name: (-)-(α)-Kainic Acid (hydrate)
Purity: ≥98%
Packaging: 5mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 78050
Product name: (-)-(α)-Kainic Acid (hydrate)
Purity: ≥98%
Packaging: 10mg
Price: $135
Updated: 2024/03/01

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KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Chemical Properties,Usage,Production

Description

(−)-(α)-Kainic acid is a cyclic analog of L-glutamate originally isolated from D. simplex that has neuroexcitatory activities. It binds to the homomeric kainate receptors GluK1, GluK2, GluK3, GluK4, and GluK5 (K_is = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively). (−)-(α)-Kainic acid (5 mM) induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes. It induces chromatin condensation and nuclear membrane fragmentation, markers of apoptosis, in primary neonatal cerebellar granule neurons when used at a concentration of 100 μM. Intracerebroventricular administration of (−)-(α)-kainic acid induces convulsive behavior in rats (ED₅₀ = 0.51 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD₅₀) value of 0.39 nmol/animal. It has been commonly used to induce seizures in rodents.

Uses

Kainic acid is used to study mechanisms of excitation-induced apoptosis and epilepsy.

Uses

Kainic acid monohydrate has been used:

As a convulsant to induce epileptogenesis and epilepsy in mice.
To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
To induce seizures in rat model.
To induce status epilepticus in adult male Wistar rats.

General Description

Kainic acid is an agonist for kainate-class ionotropic glutamate receptors. Kainate receptors directly gate ion channels and are generally excitatory. Excess stimulation by Kainic acid induces neurocytosis (apoptosis) and epileptic seizures.

Biochem/physiol Actions

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Suppliers

Canada 1 China 72 Europe 1 Germany 1 Japan 1 Switzerland 1 United Kingdom 6 United States 10 USA 1 Global 94

Hangzhou Milestone Pharmtech Co., Ltd.

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Syntechem Co.,Ltd

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Sigma-Aldrich

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Beijing NuoqiYa Biotechnology Co., Ltd.

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Pharmacodia (Beijing) Co.,Ltd

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View Lastest Price from KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE manufacturers

Career Henan Chemical Co

Product: KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE 58002-62-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

58002-62-3, KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINERelated Search:

KAINIC ACID

2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE

2-CARBOXYL-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE MONOHYDRATE

[2S-(2A,3BETA,4BETA)]-2-CAROXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID, MONOHYDRATE

(2S,3S,4S)-2-CARBOXY-4-ISOPROPENYL-3-PYRROLIDINEACETIC ACID

KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE

(-)-KAINIC ACID, MONOHYDRATE

KAINIC ACID MONOHYDRATE

KAINIC ACID MONOHYDRATE, ISOLATED FROM D

KAINIC ACID HYDRATE

Kainic acid monohydrate,2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine

[2S-(2alpha,3beta,4beta)]-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid monohydrate

3-Pyrrolidineaceticacid, 2-carboxy-4-(1-Methylethenyl)-, hydrate (1:1), (2S,3S,4S)-

(2S,3S,4S)-3-(carboxyMethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid hydrate

([2S-(2a,34]-2-Caroxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid

kainic acid monohydrate from digenea simplex

(-)-α-Kainic Acid Monohydrate

(?)-(α)-Kainic Acid hydrate

KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE USP/EP/BP

(-)-(α)-Kainic Acid (hydrate)

58002-62-3

C10H15NO4H2O

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Ligand-Gated Ion Channels

Ionotropic Glutamate Receptor Modulators

Ion Channels

Miscellaneous

Glutamate