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KAINIC ACID

Product Name
KAINIC ACID
CAS No.
487-79-6
Chemical Name
KAINIC ACID
Synonyms
KAINATE;(-)-α-Kainic Acid;Kainic;C12819;digenin;helminal;(3aαKainicaci;,4-beta))-;KAINIC ACID
CBNumber
CB2351306
Molecular Formula
C10H15NO4
Formula Weight
213.23
MOL File
487-79-6.mol
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KAINIC ACID Property

Melting point:
253-254 C
alpha 
D24 -14.8° (c = 1.01)
Boiling point:
353.22°C (rough estimate)
Density 
1.2177 (rough estimate)
refractive index 
1.4368 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
H2O: soluble
form 
White to off-white solid.
pka
2.03±0.60(Predicted)
color 
White
optical activity
-14.824 (H2O)
Water Solubility 
Soluble to 25 mM in water
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
InChI
InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChIKey
VLSMHEGGTFMBBZ-OOZYFLPDSA-N
SMILES
N1C[C@H](C(C)=C)[C@H](CC(O)=O)[C@H]1C(O)=O
EPA Substance Registry System
3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)- (487-79-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
22-24/25-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
0222
Product name
Kainicacid
Purity
≥98%(HPLC)
Packaging
1
Price
$82
Updated
2021/12/16
Tocris
Product number
7065
Product name
Kainicacid(synthetic)
Purity
≥98%(HPLC)
Packaging
10
Price
$159
Updated
2021/12/16
Tocris
Product number
0222
Product name
Kainicacid
Purity
≥98%(HPLC)
Packaging
10
Price
$173
Updated
2021/12/16
Tocris
Product number
7065
Product name
Kainicacid(synthetic)
Purity
≥98%(HPLC)
Packaging
50
Price
$669
Updated
2021/12/16
Tocris
Product number
0222
Product name
Kainicacid
Purity
≥98%(HPLC)
Packaging
50
Price
$718
Updated
2021/12/16
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KAINIC ACID Chemical Properties,Usage,Production

Description

Kainic acid (487-79-6) is a conformationally restricted glutamate analog which acts as a selective agonist at kainate receptors. CNS stimulant and neurotoxin. Kainic acid is a classic neuroexcitatory agent for induction of seizures in laboratory animals (typical dose 10-30 mg/kg).

Chemical Properties

soluble in 0.1 M NaOH

Uses

excitory amino acid, neurotoxin, neurobiology tool

Uses

Neurobiological tool.

Uses

glutamate receptor agonist, anthelmintic

Uses

(-)-α-Kainic Acid is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.

Definition

ChEBI: Kainic acid is a dicarboxylic acid, a pyrrolidinecarboxylic acid, a L-proline derivative and a non-proteinogenic L-alpha-amino acid. It has a role as an antinematodal drug and an excitatory amino acid agonist. It is a conjugate acid of a kainate(1-).

Biological Activity

Selective agonist at kainate receptors. Potent excitant and neurotoxin. Also available as part of the Kainate Receptor Tocriset™ .

storage

Room temperature

Purification Methods

Purify the acid by adsorbing on to a strongly acidic ion-exchange resin (Merck), elute the diacid with aqueous M NaOH, the eluate is evaporated, H2O is added, and filtered through a weakly acidic ion-exchange resin (Merck). The filtrate is then evaporated and recrystallised from EtOH. Its solubility is 0.1g in 1mL of 0.5N HCl. (±)--Kainic acid is recrystallised from H2O with m 230-260o. UV (MeOH): 219 (log 3.9); max 1HNMR (CCl4, 100MHz, Me4Si standard) : 1.64 (s 1H), 1.70 (s 3H), 3.24 (d J 7.5, 2H), 3.3-4.2 (1H), 3.70 (s 3H), 3.83 (s 3H), 4.35 (dd J 7.5, J 14.5, 1H), 5.21 (t J 7.5, 1H), 7.26 (t J 7.5, 1H). [Oppolzer & Andres Helv Chim Acta 62 2282 1979, Beilstein 22 III/IV 1523.]

References

1) Watkins et al. (1981), Excitatory amino acid transmitters; Ann. Rev. Pharmacol. Toxicol., 21 165

KAINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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KAINIC ACID Suppliers

China 93 Czech 1 Europe 1 Germany 2 India 1 Italy 1 Japan 2 Switzerland 1 Ukraine 1 United Kingdom 6 United States 25 USA 1 Global 135
Guangzhou Younan Technology Co., Ltd
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020-82000279 18988968278
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QQ：3283937693
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sales@ubiochem.com
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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15839
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NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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+86-27-87599188
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China
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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021-33632979
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021-34692979
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info@tsbiochem.com
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China
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8065
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58
Finetech Industry Limited
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027-87465837 19945049750
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027-8777-2287
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sales@finetechnology-ind.com
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China
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Shanghai Macklin Biochemical Co.,Ltd.
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15221275939 15221275939
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021-50706099
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shenlinxing@macklin.cn
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China
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16166
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Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
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sales_hz@milestonepharmtech.com
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China
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4853
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EMMX Biotechnology LLC
Tel
888-539-0666
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888-539-0666
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info@emmx.com
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United States
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8447
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Nanjing Vital Chemical Co., Ltd.
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025-87193546 18652950785
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025-87193546
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chemweiao@163.com
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China
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9021
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60

487-79-6, KAINIC ACIDRelated Search:

DOMOIC ACID KAINIC ACID KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE rac-Kainic Acid KAINIC ACID DIMETHYL ESTER HYDROCHLORIDE seco-Kainic acid KAINIC ACID, [VINYLIDENE-3H] acromelic acid A KAINIC ACID, G-(A-CARBOXY-2-NITROBENZYL)ESTER Kainic Acid Rabbit Polyclonal Receptors, Kainic Acid (-)-KAINIC ACID MONOHYDRAT KAINIC ACID (OPIKA-1?) KAINIC ACID, G-(A-CARBOXY-2-NITROBENZYL)ESTER HYDROCHLORIDE KAINIC ACID METHYL ESTER (-)-(ALPHA)-KAINIC ACID HYDRATE Kainic Acid, Natural KAINIC ACID DIMETHYL ESTER

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