DOMOIC ACID
- Product Name
- DOMOIC ACID
- CAS No.
- 14277-97-5
- Chemical Name
- DOMOIC ACID
- Synonyms
- C13732;Domoic;omoicaci;NSC 288031;DOMOIC ACID;L-Domic acid;(-)-Domic acid;DoMoic Acid-d3;(-)-DoMoic Acid-d3;Domoic acid, 100ppm
- CBNumber
- CB2359498
- Molecular Formula
- C15H21NO6
- Formula Weight
- 311.33
- MOL File
- 14277-97-5.mol
DOMOIC ACID Property
- Melting point:
- 213-217℃
- Boiling point:
- 451.38°C (rough estimate)
- Density
- 1.1800 (rough estimate)
- refractive index
- 1.5130 (estimate)
- storage temp.
- -20°C
- solubility
- methanol: 0.6 mg/mL
- form
- solid
- pka
- 2.08±0.60(Predicted)
- color
- white
- optical activity
- -109.612 (H2O)
- Water Solubility
- Soluble in water at 8mg/ml. Soluble in methanol at 0.6mg/ml.
- Merck
- 13,3451
- BRN
- 46376
- Stability:
- Light Sensitive
- EPA Substance Registry System
- Domoic acid (14277-97-5)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22
- Safety Statements
- 36/37
- WGK Germany
- 3
- RTECS
- UX9665100
- Hazardous Substances Data
- 14277-97-5(Hazardous Substances Data)
- Toxicity
- An excitory amino acid isolated from the red alga Chondria armata. A structural analog of kainic acid and domoic acid has been shown to be responsible for the shellfish poisoning associated with eating certain cultured blue mussels.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H370Causes damage to organs
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D6152
- Product name
- Domoic acid
- Purity
- ≥90% (HPLC)
- Packaging
- 1mg
- Price
- $234
- Updated
- 2023/01/07
- Product number
- D6152
- Product name
- Domoic acid
- Purity
- ≥90% (HPLC)
- Packaging
- 5mg
- Price
- $772
- Updated
- 2023/01/07
- Product number
- 21433
- Product name
- Domoic Acid
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- 21433
- Product name
- Domoic Acid
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- 0269
- Product name
- Domoic acid
- Purity
- ≥95%(HPLC)
- Packaging
- 500U
- Price
- $197
- Updated
- 2021/12/16
DOMOIC ACID Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Labelled Domoic Acid. Domoic Acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning ass ociated with ingestion of certain cultured blue mussels. Domoic Acid is a structural analog of Kainic acid (K135000).
Uses
Domoic Acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning associated with ingestion of certain cultured blue mussels. Domoic acid is a structural analog of Kainic acid (K135000). DA. EU regulated marine toxin.
Uses
Domoic acid has been used:
- as an excitatory neurotoxin to determine brain transcriptional response
- to study its cytotoxic, genotoxic and immunotoxic effects on the marine mussel M. edulis
- to study its neurobehavioral effects on mouse fetuses
Definition
ChEBI: A L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is an analog of kainic acid and is the neurotoxin associated with the a nesic shellfish poisoning (ASP).
General Description
Domoic acid, a heterocyclic amino acid neurotoxin is synthesized by various marine algaes. It possess some structural similarity to kainic acid.
Biological Activity
More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.
Biochem/physiol Actions
Domoic acid is a potent agonist at receptors for excitatory amino acids glutamate and kainate. It has highest affinity for AMPA/kainate receptor of any kainate agonist. It can causes excessive excitation of neurons leading to depletion of energy stores.
Purification Methods
Domoic acid (~300 mg) is purifed on a Dowex1 column (3.5 x 40 mm, 200-400 mesh, acetate form), washed with H2O until neutral, then eluted with increasing concentrations of AcOH (8L) from 0 to 0.25M. The fraction containing domoic acid (in 50mL) is collected, evaporated to dryness under reduced pressure and recrystallised from aqueous EtOH. It is a glutamate and a Kainate receptor agonist. [Impellizzeri et al. Phytochemistry 14 1549 1975, Takemoto & Diago Arch Pharm 293 627 1960, Beilstein 22/4 V 371.]
DOMOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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