ChemicalBook > CAS DataBase List > KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE

KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE

Product Name
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
CAS No.
58002-62-3
Chemical Name
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
Synonyms
KAINIC ACID MONOHYDRATE;KAINIC ACID HYDRATE;(?)-(α)-Kainic Acid hydrate;(-)-KAINIC ACID, MONOHYDRATE;(-)-α-Kainic Acid Monohydrate;(-)-(α)-Kainic Acid (hydrate);KAINIC ACID MONOHYDRATE, ISOLATED FROM D;kainic acid monohydrate from digenea simplex;2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE;(2S,3S,4S)-2-CARBOXY-4-ISOPROPENYL-3-PYRROLIDINEACETIC ACID
CBNumber
CB5351307
Molecular Formula
C10H17NO5
Formula Weight
231.25
MOL File
58002-62-3.mol
More
Less

KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Property

Melting point:
250-252°C
RTECS 
UX9665250
storage temp. 
2-8°C
solubility 
H2O: >10 mg/mL
form 
solid
color 
white
Sensitive 
Light Sensitive
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
TSCA 
No
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
K0250
Product name
Kainic acid monohydrate
Purity
≥99% (TLC)
Packaging
10mg
Price
$261
Updated
2024/03/01
Sigma-Aldrich
Product number
K0250
Product name
Kainic acid monohydrate
Purity
≥99% (TLC)
Packaging
50mg
Price
$1150
Updated
2024/03/01
Alfa Aesar
Product number
J66590
Product name
Kainic acid monohydrate, 98%
Packaging
10mg
Price
$177
Updated
2023/06/20
Cayman Chemical
Product number
78050
Product name
(-)-(α)-Kainic Acid (hydrate)
Purity
≥98%
Packaging
5mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
78050
Product name
(-)-(α)-Kainic Acid (hydrate)
Purity
≥98%
Packaging
10mg
Price
$135
Updated
2024/03/01
More
Less

KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Chemical Properties,Usage,Production

Description

(−)-(α)-Kainic acid is a cyclic analog of L-glutamate originally isolated from D. simplex that has neuroexcitatory activities. It binds to the homomeric kainate receptors GluK1, GluK2, GluK3, GluK4, and GluK5 (Kis = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively). (−)-(α)-Kainic acid (5 mM) induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes. It induces chromatin condensation and nuclear membrane fragmentation, markers of apoptosis, in primary neonatal cerebellar granule neurons when used at a concentration of 100 μM. Intracerebroventricular administration of (−)-(α)-kainic acid induces convulsive behavior in rats (ED50 = 0.51 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.39 nmol/animal. It has been commonly used to induce seizures in rodents.

Uses

Kainic acid is used to study mechanisms of excitation-induced apoptosis and epilepsy.

Uses

Kainic acid monohydrate has been used:

  • As a convulsant to induce epileptogenesis and epilepsy in mice.
  • To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
  • To induce seizures in rat model.
  • To induce status epilepticus in adult male Wistar rats.

General Description

Kainic acid is an agonist for kainate-class ionotropic glutamate receptors. Kainate receptors directly gate ion channels and are generally excitatory. Excess stimulation by Kainic acid induces neurocytosis (apoptosis) and epileptic seizures.

Biochem/physiol Actions

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Suppliers

Canada 1 China 78 Europe 1 Germany 1 Japan 1 Switzerland 1 United Kingdom 6 United States 11 USA 1 Global 101
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Kainic.com
Tel
--
Fax
--
Email
info@Kainic.com
Country
United States
ProdList
330
Advantage
38
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
More
Less

View Lastest Price from KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE manufacturers

Career Henan Chemical Co
Product
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE 58002-62-3
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

58002-62-3, KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINERelated Search:

KAINIC ACID

  • 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
  • 2-CARBOXYL-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE MONOHYDRATE
  • [2S-(2A,3BETA,4BETA)]-2-CAROXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID, MONOHYDRATE
  • (2S,3S,4S)-2-CARBOXY-4-ISOPROPENYL-3-PYRROLIDINEACETIC ACID
  • KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
  • (-)-KAINIC ACID, MONOHYDRATE
  • KAINIC ACID MONOHYDRATE
  • KAINIC ACID MONOHYDRATE, ISOLATED FROM D
  • KAINIC ACID HYDRATE
  • Kainic acid monohydrate,2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
  • [2S-(2alpha,3beta,4beta)]-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid monohydrate
  • 3-Pyrrolidineaceticacid, 2-carboxy-4-(1-Methylethenyl)-, hydrate (1:1), (2S,3S,4S)-
  • (2S,3S,4S)-3-(carboxyMethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid hydrate
  • ([2S-(2a,34]-2-Caroxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid
  • kainic acid monohydrate from digenea simplex
  • (-)-α-Kainic Acid Monohydrate
  • (?)-(α)-Kainic Acid hydrate
  • KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE USP/EP/BP
  • (-)-(α)-Kainic Acid (hydrate)
  • 58002-62-3
  • C10H15NO4H2O
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Ligand-Gated Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Miscellaneous
  • Glutamate