DIMETHYLZINC Property

Melting point:

-42°C

Boiling point:

44-46 °C

Density 

0.92 g/mL at 20 °C

Flash point:

30 °F

storage temp. 

0-6°C

form 

liquid

color 

colorless

Sensitive 

Air & Moisture Sensitive

Merck 

14,3263

BRN 

3587195

InChIKey

AXAZMDOAUQTMOW-UHFFFAOYSA-N

CAS DataBase Reference

544-97-8(CAS DataBase Reference)

EPA Substance Registry System

Zinc, dimethyl- (544-97-8)

Safety

Hazard Codes 

F,C,N,Xn

Risk Statements 

11-14-34-50/53-65-67-63-51/53-48/20-17-14/15-36/38

Safety Statements 

26-45-61-62-60-43-36/37/39-33-29-16-46-43A-36/37

RIDADR 

UN 3399 4.3/PG 2

WGK Germany 

2

F 

10-23

TSCA 

Yes

HazardClass 

4.2

PackingGroup 

I

HS Code 

29319090

Hazardous Substances Data

544-97-8(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H250Catches fire spontaneously if exposed to air

H252Self-heating in large quantities; may catch fire

H260In contact with water releases flammable gases which may ignite spontaneously

H261In contact with water releases flammable gas

H304May be fatal if swallowed and enters airways

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H336May cause drowsiness or dizziness

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P222Do not allow contact with air.

P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.

P231+P232Handle under inert gas. Protect from moisture.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P422Store contents under …

DIMETHYLZINC Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

Dimethylzinc is pharmaceutical compound comprising Hemiasterlin derivatives and its antibody conjugate for treatment of cancer.

Uses

Dimethylzinc solution can be used as:

• A catalyst with nickel for the stereoselective C?2 alkenylation and dialkenylation of pyridine derivatives by alkynes to give monoalkenylation products.
• A reagent with aldehydes and 2-methoxyaniline for the synthesis of enantioselective alkyl and aralkyl secondary amines via one-pot three-component coupling reaction in the presence of zirconium tetraisopropoxide.
• A methylating reagent for methylation of fluoroalkylated pyruvates in the presence of copper/chiral diphosphine catalyst.

Uses

Activator for radical trifluoromethylation of silyl enol ethers leading to α-trifluoromethyl ketones.1

Definition

ChEBI: Dimethylzinc is a dialkylzinc compound.

General Description

Mobile liquid, with peculiar garlic odor.

Air & Water Reactions

Highly flammable. Ignites in air and burns with a blue flame giving off a peculiar garlicky odor. Explodes in oxygen or ozone. Reacts violently with water to generate methane [Merck, 11th ed., 1989; Brauer(1965)]. Very slow oxidation with traces of air to give methylzinc methylate.

Reactivity Profile

DIMETHYLZINC is very reactive, acts as a strong reducing agent. Combines with acids, with alcohols (methanol, ethanol), and 2-2-dichloropropane as well as with water with explosive violence. When heated to decomposition emits toxic fumes of zinc oxide [Bretherick, 5th ed., 1995, p. 354]. Oxidants may yield peroxide formation, which is explosive.

Health Hazard

Inhalation of mist or vapor causes immediate irritation of upper respiratory tract. Excessive or prolonged inhalation of fumes from ignition or decomposition may cause ``metal fume fever'' (sore throat, headache, fever, chills, nausea, vomiting, muscular aches, perspiration, constricting sensation in lungs, weakness, sometimes prostration). Symptoms usually last 12-24 hrs. Eyes are immediately and severely irritated by liquid, vapor, or dilute solutions. If not removed by thorough flushing with water, chemical may permanently damage cornea. Skin will undergo thermal and acid burns when chemical reacts with moisture in skin. Unless washed quickly, skin may be scarred. Treat dilute solutions with same precautions as concentrated liquid. Ingestion, while unlikely, would cause immediate burns at site of contact. Nausea, vomiting, cramps, and diarrhea may follow. Tissues may ulcerate if not treated.