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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE

Product Name
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
CAS No.
159190-45-1
Chemical Name
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
Synonyms
L-NIL HCL;L-NIL DIHYDROCHLORIDE;L-N6-(1-Iminoethyl)lysine;OQIBCXRAFAHXMM-KLXURFKVSA-N;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-Lysine ω-acetamidine dihydrochloride;N6-(1-Iminoethyl)lysine dihydrochloride;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;LNIL dihydrochloride,L NIL dihydrochloride
CBNumber
CB5353543
Molecular Formula
C8H18ClN3O2
Formula Weight
223.7
MOL File
159190-45-1.mol
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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Property

storage temp. 
-20°C
solubility 
DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
form 
White to off-white solid.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I8021
Product name
L-N6-(1-Iminoethyl)lysine dihydrochloride
Packaging
10mg
Price
$132
Updated
2024/03/01
Cayman Chemical
Product number
80310
Product name
L-NIL (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
80310
Product name
L-NIL (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$9
Updated
2021/12/16
Cayman Chemical
Product number
80310
Product name
L-NIL (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$148
Updated
2024/03/01
Cayman Chemical
Product number
80310
Product name
L-NIL (hydrochloride)
Purity
≥95%
Packaging
100mg
Price
$276
Updated
2024/03/01
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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.

Uses

L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:

  • to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
  • to study its effects on leptin-induced inflammation in hepatocytes
  • to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)

Definition

ChEBI: N(6)-acetimidoyl-L-lysine dihydrochloride is a hydrochloride salt prepared from N(6)-acetimidoyl-L-lysine and two equivalents of hydrogen chloride. A selective inhibitor of inducible nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It contains a N(6)-acetimidoyl-L-lysinium(2+).

Biochem/physiol Actions

Selective inhibitor of inducible nitric oxide synthase (iNOS).

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Suppliers

China 16 Japan 2 Switzerland 2 United Kingdom 1 United States 6 Global 27
TargetMol Chemicals Inc.
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Cayman Chemical Company
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159190-45-1, L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDERelated Search:

NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE L-N5-(1-IMINOETHYL)ORNITHINE*HYDROCHLORI DE Aminoguanidine bicarbonate NG-MONOMETHYL-L-ARGININE ACETATE AMINOGUANIDINE HEMISULFATE IroMycin A 2-IMINOBIOTIN HYDROBROMIDE N'-Nitro-L-arginine-methyl ester hydrochloride S-ETHYLISOTHIOUREA HYDROBROMIDE NG-MONOMETHYL-D-ARGININE MONOACETATE 3-BROMO-7-NITROINDAZOLE S-ISOPROPYLTHIOUREA HYDROBROMIDE L-THIOCITRULLINE DIHYDROCHLORIDE L-NAA HCL 7-NINA L-Lysine dihydrochloride L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE D-N6-(1-IMINOETHYL)-LYSINE DIHYDROCHLORIDE

  • L-NIL DIHYDROCHLORIDE
  • L-NIL HCL
  • L-N6-(1-IMINOETHYL)-LYSINE 2HCL
  • L-N6-(1-IMINOETHYL)LYSINE, DIHCL
  • L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
  • N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
  • L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2)
  • L-Lysine ω-acetamidine dihydrochloride
  • OQIBCXRAFAHXMM-KLXURFKVSA-N
  • L-N6-(1-Iminoethyl)lysine
  • LNIL dihydrochloride,L NIL dihydrochloride
  • N6-(1-Iminoethyl)lysine dihydrochloride
  • 159190-45-1
  • Nitric Oxide Synthase
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • L to O
  • BioChemical
  • Biochemicals and Reagents
  • Nitric Oxide