ChemicalBook > CAS DataBase List > RAS INHIBITORY PEPTIDE
RAS INHIBITORY PEPTIDE
- Product Name
- RAS INHIBITORY PEPTIDE
- CAS No.
- 159088-48-9
- Chemical Name
- RAS INHIBITORY PEPTIDE
- Synonyms
- VPPPVPPRRR-NH2;RAS INHIBITORY PEPTIDE;Sos SH3 domain inhibitor;Sos SH3 domain inhibitor inhibitor;VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG;HSOS (1149-1158) N10 SH3 BINDING DOMAIN;H-VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG-OH;L-Arginine, L-valyl-L-prolyl-L-prolyl-L-prolyl-L-valyl-L-prolyl-L-prolyl-L-arginyl-L-arginyl-
- CBNumber
- CB5356014
- Molecular Formula
- C53H91N19O11
- Formula Weight
- 1170.41
- MOL File
- 159088-48-9.mol
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RAS INHIBITORY PEPTIDE Property
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: Miscible; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- pka
- 3.31±0.10(Predicted)
- Sequence
- Val-Pro-Pro-Pro-Val-Pro-Pro-Arg-Arg-Arg
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17474
- Product name
- Ras Inhibitory Peptide
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17474
- Product name
- Ras Inhibitory Peptide
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $116
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17474
- Product name
- Ras Inhibitory Peptide
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $502
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17474
- Product name
- Ras Inhibitory Peptide
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $869
- Updated
- 2024/03/01
Usbiological
- Product number
- R1198-40
- Product name
- Ras Inhibitory Peptide
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
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RAS INHIBITORY PEPTIDE Chemical Properties,Usage,Production
Description
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.
Uses
Ras Inhibitory Peptide (VPPPVPPRRR) is a Ras inhibitor with antitumor activity[1].
References
[1] Pei-Yin Ho, et al. Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Mol Cancer Ther. 2006 Dec;5(12):3130-8. DOI:10.1158/1535-7163.MCT-06-0457
RAS INHIBITORY PEPTIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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