ChemicalBook > CAS DataBase List > 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE

2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE

Product Name
2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE
CAS No.
106461-41-0
Chemical Name
2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE
Synonyms
Dhmt;T 1330;2,4 Dihydro-4;5-LOX inhibitor;4-TRIAZOLE-3-ONE;Hydroxyl compound;Itraconazole Impurity 22;Itraconazole Hydroxy Isobutyltriazolone;piperazinyl]phenyl]-2-(1-methylpropyl)-;2,4-dihydro-4-[4-[4-4-(hydroxyphenyl)-1-
CBNumber
CB5356302
Molecular Formula
C22H27N5O2
Formula Weight
393.48
MOL File
106461-41-0.mol
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2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE Property

Melting point:
177-179°C
Boiling point:
587.9±60.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
12.18±0.30(Predicted)
color 
Off-White Pale Brown
InChI
InChI=1S/C22H27N5O2/c1-3-17(2)27-22(29)26(16-23-27)20-6-4-18(5-7-20)24-12-14-25(15-13-24)19-8-10-21(28)11-9-19/h4-11,16-17,28H,3,12-15H2,1-2H3
InChIKey
FFAQILVGBAELHN-UHFFFAOYSA-N
SMILES
N1=CN(C2=CC=C(N3CCN(C4=CC=C(O)C=C4)CC3)C=C2)C(=O)N1C(C)CC
CAS DataBase Reference
106461-41-0(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot
Product number
CD11357608
Product name
1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
Purity
95+%
Packaging
1g
Price
$274
Updated
2026/05/27
Crysdot
Product number
CD11357608
Product name
1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
Purity
95+%
Packaging
5g
Price
$878
Updated
2026/05/27
Chemenu
Product number
CM133667
Product name
2-(sec-butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
Purity
95%
Packaging
1g
Price
$295
Updated
2026/05/26
AHH
Product number
MT-09718
Product name
2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1methylpropyl)-3H-1,2,4-triazole-3-one
Purity
97%
Packaging
10g
Price
$888
Updated
2026/05/26
AHH
Product number
MT-09718
Product name
2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1methylpropyl)-3H-1,2,4-triazole-3-one
Purity
97%
Packaging
10g
Price
$888
Updated
2026/05/25
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2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE Chemical Properties,Usage,Production

Chemical Properties

Light Grey Powder

Uses

An intermediate in the synthesis of Itraconazole.

2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE Suppliers

Canada 2 China 154 Germany 2 India 24 United Kingdom 4 United States 17 Global 203
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View Lastest Price from 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE manufacturers

R&D Scientific Inc.
Product
2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one 106461-41-0
Price
US $780.00/g
Min. Order
1g
Purity
99
Supply Ability
5000 Kg
Release date
2025-11-21
Career Henan Chemical Co
Product
2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE 106461-41-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-11

106461-41-0, 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONERelated Search:

trans-Itraconazole 2,4-dihydro-4-[[4-(4-hydroxyphenyl)-1-piperazinyl]-phenyl]-2-(1-methylpropyl)-3h-1,2,4-triazole-3-on HYDROXY ITRACONAZOLE Itraconazole 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one N-Desalkyl Itraconazole Itraconazole Impurity 34 Butyl Itraconazole 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-4-(4-nitrophenyl)piperazine cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl benzoate Des-(1-(sec-butyl)-1H-1,2,4-triazol-5(4H)-one) Itraconazole Propyl Itraconazole (1,2,4-Triazol-4-yl) Itraconazole cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol Isopropyl Itraconazole DPUDRFOQNBKHMF-YZNIXAGQSA-N 1-(4-AMINOPHENYL)-4-(4-METHOXYPHENYL)PIPERAZINE

  • Itraconazole Hydroxy Isobutyltriazolone IMpurity
  • 1-(sec-butyl)-4-(2-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
  • 1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
  • 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-
  • 2-sec-butyl-4-{4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl}-2h-1,2,4-triazol-3(4h)-one
  • 2-butan-2-yl-4-[2-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-1,2,4-triazol-3-one
  • 2,4-Dihydro-4-[4-[4-(4-Hydroxyphenyl)-1-Piperazinyl)Phenyl]-2-(1-Methyl Propyl)-3H-1,2,4-Triazole-3-One.
  • Itraconazole Hydroxy Isobutyltriazolone
  • 2,4-DIHYDRO-4-[(4-HYDROXYPHENYL)-1-PIPER AZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2 4-TRIAZOLE-3-ONE
  • 2,4-Dihydro-4-[4-[4-(4-Hydroxyphenyl)-1-Piperazinyl]Phenyl]-2-(1-Methylpropyl)-3
  • 2,4-Dihydro-4-[4-[4-(4-Hydroxyphenyl)-1-Piperazinyl]Phenyl]-2-(1-Methylpropyl)-3h-1,2,4-Triazol-3-One
  • Dhmt
  • 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one(DHMT)
  • 2,4-Dihydro-4[4-[4-(4-Hydroxyphenyl)-1-Piperazinyl]-Phenyl]-2-(1-Methylpropyl)-3H-1,Triazole-3-One
  • 2,4-Dihydro-4-[4-[4-(4-Hydroxylphenyl)Piperazin-l-ylPhenyl-2-(l-Methylpropyl)-3H-1,2,4-Triazol-3-One
  • 2,4-Dichloro-4-[[4-(4-hydroxyphenyl)-1-piperazinyl]-phen-yl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
  • 2,4-Dihydro-4-{4-Hydroxyphenyl)-2-(1- Methyl Propyl)-3H-1,2,4-Triazole-3-One
  • 2,4-dihydro-4-[4-[4-4-(hydroxyphenyl)-1-
  • piperazinyl]phenyl]-2-(1-methylpropyl)-
  • Dihydro hydroxyphenyl piperazinyl phenyl methylpropyl triazole one
  • T 1330
  • 2,4-DIHYDRO-4-[4-[4-(HYDROXYPHENYL)-1-PIPERAZINYL]-PHENYL]-2-(SEC-BUTYL)-3H-1,2,4-TRIAZOL-3-ONE
  • 2-SEC-BUTYL-4-[4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL]-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE
  • 2,4-DIHYDRO-4-[4-[4-(4-HYDROXYPHENYL)-1-PIPERAZINYL]-PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOL-3-ONE
  • 2,4-DIHYDRO-4-[4-[4-(4-HYDROXYPHENYL)-1-PIPERAZINYL]PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE
  • 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE
  • 1-SEC BUTYL-[4[4(4-HYDROXYPHENYL)-1-PIPERAZINYL]-PHENYL]-1,2,4-TRIAZOLO-5-ONE
  • 4-[4-[4-[4-Hydroxyphenyl]piperazin-1-yl]phenyl]-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
  • Itraconazole Impurity 22
  • 2, 4 - dihydro - 4 - [[4 - (4 - hydroxy phenyl) - 1 - piperazine base] phenyl] - 2 - (1 - methyl propyl) - 3 h - 1, 4-trichlorobenzene three azole nitrogen - 3 - ketone
  • 3H-1,2,4-Triazol-3-one, 2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-
  • 2,4-DIHYDRO-4-[4-[4-(4-HYDROXYLPHENYL)PIPERAZIN-1-YL]PHEN-
  • ,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE
  • 2,4-Dihydro-4-[4-[4-(4-hydroxylphenyl)piperazin-1-yl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
  • 4-TRIAZOLE-3-ONE
  • 4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1
  • 2,4 Dihydro-4
  • 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1-piperazinyl]-phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one (IT – VII)--S
  • 4-[4-[4-(4-Hydroxyphenyl)piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
  • 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1- piperazinyl]phenyl]-2-(1 methylpropyl)-3H-1,2,4- triazol-3-1
  • Hydroxyl compound
  • 1-(sec-Butyl)-4-[2-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-1H-1,2,4-triazol-5(4H)-one
  • 5-LOX inhibitor
  • 4-[4-[4-(4-Hydroxyphenyl)piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazo
  • 2,4-Dihydro-4-[4-[4-(4-Hydroxyphenyl]-1-Piperazinyl]-Phenyl]-2-(1-Methylpropyl)-3H-1,2,4-Triazol-3-One [IT-7]
  • 2,4-dihydro-4-[[4-(4-hydroxyphenyl)-1-azineyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazazole-3-one
  • 106461-41-0
  • C22H27N5O2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals