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METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE

Product Name
METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE
CAS No.
22288-79-5
Chemical Name
METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE
Synonyms
methyl 3-acetamidothiophene-2-carboxylate;METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE;3-AcetylaMino-thiophene-2-carboxylic acid Methyl ester;2-Thiophenecarboxylic acid, 3-(acetylamino)-, methyl ester
CBNumber
CB5358412
Molecular Formula
C8H9NO3S
Formula Weight
199.23
MOL File
22288-79-5.mol
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METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE Property

Melting point:
94-95°C
Boiling point:
399.9±27.0 °C(Predicted)
Density 
1.329±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
14.35±0.70(Predicted)
Appearance
White to off-white Crystal
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M293238
Product name
Methyl3-Acetamidothiophene-2-carboxylate
Packaging
500mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
1279AB
Product name
Methyl3-acetamidothiophene-2-carboxylate
Packaging
1g
Price
$113
Updated
2021/12/16
Matrix Scientific
Product number
045025
Product name
Methyl 3-(acetylamino)-2-thiophenecarboxylate
Purity
>95%
Packaging
1g
Price
$228
Updated
2021/12/16
Matrix Scientific
Product number
045025
Product name
Methyl 3-(acetylamino)-2-thiophenecarboxylate
Purity
>95%
Packaging
5g
Price
$524
Updated
2021/12/16
AK Scientific
Product number
1279AB
Product name
Methyl3-acetamidothiophene-2-carboxylate
Packaging
25g
Price
$621
Updated
2021/12/16
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METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE Chemical Properties,Usage,Production

Synthesis

22288-78-4

75-36-5

22288-79-5

Methyl 3-amino-2-thiophenecarboxylate (3.14 g, 20.0 mmol) was dissolved in pyridine (20 mL) and acetyl chloride (1.5 mL, 21 mmol) was added slowly and dropwise under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 3 hours, then cooled again in an ice bath and supplemented with acetyl chloride (0.3 mL, 4 mmol). Stirring was continued at room temperature for 1.5 h. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The resulting solid product was suspended and washed with water to give the final methyl 3-acetylaminothiophene-2-carboxylate (3.80 g, 19.1 mmol, 96% yield).

References

[1] Patent: JP2018/95564, 2018, A. Location in patent: Paragraph 0097-0099
[2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 215 - 227
[3] Patent: US2008/4325, 2008, A1. Location in patent: Page/Page column 18
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 1, p. 9 - 12

METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE Suppliers

China 45 France 1 Germany 1 India 1 The Netherlands 1 United Kingdom 2 United States 9 Global 60
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
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40228
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Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
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11035
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Chiba Pharmaceutical Science and technology Co, Ltd.
Tel
0531-81313138 13066006660
Fax
QQ: 3366077777
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chibapharm@foxmail.com
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China
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3991
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Shanghai civi chemical technology co.,Ltd
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86-21-34053660
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86-21-34053661
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sale@labgogo.com
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China
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9865
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Nanjing Norris-Pharm Technology Co., Ltd
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18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
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China
ProdList
8878
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Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
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55
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
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58
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
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22288-79-5, METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATERelated Search:

METHYL 3-[(2-CHLOROACETYL)AMINO]THIOPHENE-2-CARBOXYLATE METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE METHYL 3-[(2-BROMOACETYL)AMINO]THIOPHENE-2-CARBOXYLATE METHYL 3-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)THIOPHENE-2-CARBOXYLATE METHYL 5-(TERT-BUTYL)-3-[(2-CHLOROACETYL)AMINO]THIOPHENE-2-CARBOXYLATE METHYL 3-(ACETOACETYLAMINO)-2-THIOPHENECARBOXYLATE METHYL 3-[(2,3,3-TRICHLOROACRYLOYL)AMINO]THIOPHENE-2-CARBOXYLATE METHYL 5-(3-THIENYL)-3-[(2,3,3-TRICHLOROACRYLOYL)AMINO]THIOPHENE-2-CARBOXYLATE BUTTPARK 146\18-79 METHYL 3-[(2-MORPHOLINOACETYL)AMINO]-2-THIOPHENECARBOXYLATE AKOS 93083 METHYL 3-((3-[(3-([2-(METHOXYCARBONYL)-3-THIENYL]AMINO)-3-OXOPROPYL)DITHIO]PROPANOYL)AMINO)THIOPHENE-2-CARBOXYLATE METHYL 5-(TERT-BUTYL)-3-[(2,3,3-TRICHLOROACRYLOYL)AMINO]THIOPHENE-2-CARBOXYLATE METHYL 3-([3-(CHLOROMETHYL)BENZOYL]AMINO)THIOPHENE-2-CARBOXYLATE METHYL 3-((3-(2-CHLORO-6-FLUOROPHENYL)-5-METHYLISOXAZOL-4-YL)CARBONYLAMINO)THIOPHENE-2-CARBOXYLATE METHYL 5-(4-CHLOROPHENYL)-3-[(2,3,3-TRICHLOROACRYLOYL)AMINO]THIOPHENE-2-CARBOXYLATE METHYL 3-[(2,2-DICHLOROACETYL)AMINO]-5-(3-THIENYL)THIOPHENE-2-CARBOXYLATE METHYL 3-((2-[(4-CHLOROPHENYL)SULFANYL]ACETYL)AMINO)-2-THIOPHENECARBOXYLATE

  • METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE
  • methyl 3-acetamidothiophene-2-carboxylate
  • 3-AcetylaMino-thiophene-2-carboxylic acid Methyl ester
  • 2-Thiophenecarboxylic acid, 3-(acetylamino)-, methyl ester
  • 22288-79-5