ChemicalBook > CAS DataBase List > METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE

METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE

Product Name
METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE
CAS No.
22288-79-5
Chemical Name
METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE
Synonyms
methyl 3-acetamidothiophene-2-carboxylate;METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE;3-AcetylaMino-thiophene-2-carboxylic acid Methyl ester;2-Thiophenecarboxylic acid, 3-(acetylamino)-, methyl ester
CBNumber
CB5358412
Molecular Formula
C8H9NO3S
Formula Weight
199.23
MOL File
22288-79-5.mol
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METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE Property

Melting point:
94-95°C
Boiling point:
399.9±27.0 °C(Predicted)
Density 
1.329±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
14.35±0.70(Predicted)
Appearance
White to off-white Crystal
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M293238
Product name
Methyl3-Acetamidothiophene-2-carboxylate
Packaging
500mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
1279AB
Product name
Methyl3-acetamidothiophene-2-carboxylate
Packaging
1g
Price
$113
Updated
2021/12/16
Matrix Scientific
Product number
045025
Product name
Methyl 3-(acetylamino)-2-thiophenecarboxylate
Purity
>95%
Packaging
1g
Price
$228
Updated
2021/12/16
Matrix Scientific
Product number
045025
Product name
Methyl 3-(acetylamino)-2-thiophenecarboxylate
Purity
>95%
Packaging
5g
Price
$524
Updated
2021/12/16
AK Scientific
Product number
1279AB
Product name
Methyl3-acetamidothiophene-2-carboxylate
Packaging
25g
Price
$621
Updated
2021/12/16
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METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE Chemical Properties,Usage,Production

Synthesis

22288-78-4

75-36-5

22288-79-5

Methyl 3-amino-2-thiophenecarboxylate (3.14 g, 20.0 mmol) was dissolved in pyridine (20 mL) and acetyl chloride (1.5 mL, 21 mmol) was added slowly and dropwise under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 3 hours, then cooled again in an ice bath and supplemented with acetyl chloride (0.3 mL, 4 mmol). Stirring was continued at room temperature for 1.5 h. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The resulting solid product was suspended and washed with water to give the final methyl 3-acetylaminothiophene-2-carboxylate (3.80 g, 19.1 mmol, 96% yield).

References

[1] Patent: JP2018/95564, 2018, A. Location in patent: Paragraph 0097-0099
[2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 215 - 227
[3] Patent: US2008/4325, 2008, A1. Location in patent: Page/Page column 18
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 1, p. 9 - 12

METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE Suppliers

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22288-79-5, METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATERelated Search:

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  • METHYL 3-(ACETYLAMINO)-2-THIOPHENECARBOXYLATE
  • methyl 3-acetamidothiophene-2-carboxylate
  • 3-AcetylaMino-thiophene-2-carboxylic acid Methyl ester
  • 2-Thiophenecarboxylic acid, 3-(acetylamino)-, methyl ester
  • 22288-79-5