ChemicalBook > CAS DataBase List > 1,5-ISOQUINOLINEDIOL

1,5-ISOQUINOLINEDIOL

Product Name: 1,5-ISOQUINOLINEDIOL
CAS No.: 5154-02-9
Chemical Name: 1,5-ISOQUINOLINEDIOL
Synonyms: DHQ;DIQ;NSC 65585;1,5-ISOQUINOLINEDIOL;isoquinoline-1,5-diol;PARP Inhibitor IV, IQD;5-HYDROXYISOCARBOSTYRIL;1,5-Isoquinolinediol,98%;5-Hydroxy-isoquinolinone;1,5-DIHYDROXYISOQUINOLINE
CBNumber: CB5360303
Molecular Formula: C9H7NO2
Formula Weight: 161.16
MOL File: 5154-02-9.mol

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1,5-ISOQUINOLINEDIOL Property

Melting point:: 270-275 °C
Boiling point:: 287.44°C (rough estimate)
Density: 1.2480 (rough estimate)
refractive index: 1.5050 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO: >36 mg/mL
form: solid
pka: 8.52±0.20(Predicted)
color: off-white
InChI: InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChIKey: LFUJIPVWTMGYDG-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C(O)=CC=C2)C=CN1
CAS DataBase Reference: 5154-02-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 419800
Product name: PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem
Purity: The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
Packaging: 5MG
Price: $96.4
Updated: 2023/01/07

Sigma-Aldrich

Product number: I138
Product name: 1,5-Isoquinolinediol
Purity: ≥98% (HPLC), powder
Packaging: 5MG
Price: $59.9
Updated: 2022/05/15

Cayman Chemical

Product number: 14438
Product name: 1,5-Isoquinolinediol
Purity: ≥98%
Packaging: 5mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 14438
Product name: 1,5-Isoquinolinediol
Purity: ≥98%
Packaging: 25mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 14438
Product name: 1,5-Isoquinolinediol
Purity: ≥98%
Packaging: 100mg
Price: $207
Updated: 2024/03/01

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1,5-ISOQUINOLINEDIOL Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

Chemical Properties

white to off-white solid

Uses

Reagent used in the preparation of PARP inhibitor.

Uses

1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.

Definition

ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.

General Description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

References

[1] M BANASIK. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.[J]. The Journal of Biological Chemistry, 1992, 267 3: 1569-1575.
[2] T RUSCETTI. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.[J]. The Journal of Biological Chemistry, 1998, 273 23: 14461-14467. DOI: 10.1074/jbc.273.23.14461
[3] PRABAL K. CHATTERJEE. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo[J]. FASEB Journal, 2000, 14 5: 641-651. DOI: 10.1096/fasebj.14.5.641
[4] J BOWES. Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress.[J]. Cardiovascular Research, 1999, 41 1: 126-134. DOI: 10.1016/s0008-6363(98)00221-1
[5] JOO-YUN BYUN. Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.[J]. Molecular Pharmacology, 2009, 76 4: 734-744. DOI: 10.1124/mol.109.056259
[6] YOUNG-HEE KANG. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria.[J]. Cancer research, 2004, 64 24: 8960-8967. DOI: 10.1158/0008-5472.can-04-1830

1,5-ISOQUINOLINEDIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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1,5-ISOQUINOLINEDIOL Suppliers

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View Lastest Price from 1,5-ISOQUINOLINEDIOL manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1,5-Isoquinolinediol 5154-02-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-04-07

5154-02-9, 1,5-ISOQUINOLINEDIOLRelated Search:

1,5-ISOQUINOLINEDIOL 7-isoquinolinediol,1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-h 1,2,3,4-TETRAHYDRO-1-METHYL-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-Tetrahydro-1-methyl-6,7-Isoquinolinediol 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methyl-6,7-isoquinolinediol 5-Hydroxyisoquinoline Isoquinoline Isocarbostyril 1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE 98% 1-(3,4-Dihydroxybenzyl)-6,7-isoquinolinediol Tretoquinol (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride 5-METHOXY-2H-ISOQUINOLIN-1-ONE 6,7-Isoquinolinediol, 1-propyl- (9CI) d-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 6,7-Isoquinolinediol, 1-(1-methylethyl)- (9CI) 6,7-Isoquinolinediol, 1-[(1S)-1,2-dihydroxyethyl]-1,2,3,4-tetrahydro- (9CI) 3,4-Dihydro-6,7-isoquinolinediol. Tretoquinol hydrochloride

1,5-ISOQUINOLINEDIOL

1,5-DIHYDROXYISOQUINOLINE

5-HYDROXYISOCARBOSTYRIL

5-HYDROXY-1(2H)-ISOQUINOLINE

5-HYDROXY-1(2H)-ISOQUINOLINONE

1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE)

1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ

5-Hydroxyisoquinoline-1(2H)-one

DHQ

1,5-Isoquinolinediol,98%

1,5-dihydroxy-1(2H)-isoquinoline

1,5-Isoquinolinediol ,97%

isoquinoline-1,5-diol

5-hydroxyisoquinolin-1(2H)-one

5-Hydroxy-isoquinolinone

NSC 65585

DIQ

1(2H)-Isoquinolinone, 5-hydroxy-

5-hydroxy-1,2-dihydroisoquinolin-1-one

Isoquinolinediol, 1,5- - NSC 65585

PARP,diabetic,1188540,oxidative,retinopathy,1,5 Isoquinolinediol,stress,inhibit,NADPH,1,5-Isoquinolinediol,Inhibitor,1,5Isoquinolinediol,oxidase,poly ADP ribose polymerase

1,5-Isoquinolinediol, PARP-1 inhibitor

1,5-Isoquinolinediol, 10 mM in DMSO

PARP Inhibitor IV, IQD

1,5-Isoquinolinediol - [K94620]

5154-02-9

PARP Regulators

PARP

BioChemical

Apoptosis and Cell Cycle

Cell Signaling and Neuroscience

Cell Biology

Aromatics

Inhibitors