(S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE

Product Name: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE
CAS No.: 191231-58-0
Chemical Name: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE
Synonyms: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE;(S)-1-Boc-2-(N-methylaminomethyl)-pyrrolidine;(S)-N-methyl-1-(1-Bocpyrrolidin-2-yl)methanamine;(S)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate;tert-Butyl (S)-2-((methylamino)methyl)pyrrolidine-1-carboxylate;tert-butyl (2S)-2-[(MethylaMino)Methyl]pyrrolidine-1-carboxylate;(S)-2-[(Methylamino)methyl]-1-pyrrolidinecarboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 2-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (2S)-
CBNumber: CB5360343
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 191231-58-0.mol

More

Less

(S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE Property

Boiling point:: 282℃
Density: 1.004
Flash point:: 124℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.17±0.10(Predicted)
Appearance: Colorless to light yellow Viscous Liquid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B814795
Product name: (S)-tert-Butyl2-((methylamino)methyl)pyrrolidine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142890
Product name: (S)-tert-Butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate
Packaging: 250mg
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: 8504BB
Product name: (S)-Tert-butyl2-((methylamino)methyl)pyrrolidine-1-carboxylate
Packaging: 250mg
Price: $323
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142890
Product name: (S)-tert-Butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate
Packaging: 500mg
Price: $405
Updated: 2021/12/16

Activate Scientific

Product number: AS101610
Product name: (S)-1-Boc-2-(methylaminomethyl)pyrrolidine
Purity: 95% ee
Packaging: 1g
Price: $458
Updated: 2021/12/16

More

Less

(S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE Chemical Properties,Usage,Production

Synthesis

627-37-2

69610-40-8

191231-58-0

The general procedure for the synthesis of tert-butyl (S)-2-((methylamino)methyl)pyrrolidine-1-carboxylate from N-methylallylamine and N-BOC-L-prolinol was as follows: Boc-L-prolinol (6.03 g, 30 mmol) was dissolved in anhydrous DCM (120 mL), TEA (15 mL) and anhydrous DMSO (33 mL) were added. Subsequently, PyrSO3 powder (total 30 g) was added in batches of 5 g each for 2 h until the LCMS assay showed complete consumption of raw alcohol. The reaction mixture was washed sequentially with 6N NaHSO4 (3 × 100 mL) and water (2 × 100 mL) and then transferred to a flask. To the flask was added N-methylallylamine (2.8 mL, 29 mmol) followed by NaBH(OAc)3 (6.36 g, 30 mmol). After stirring for 30 min, the mixture was transferred to a partition funnel, the organic layer was washed with water (100 mL), dried and concentrated to give an oily product (4.5 g). This oily product was dissolved in THF (100 mL) and bubbled with N2 gas for 10 minutes. Thiosalicylic acid (4.1 g, 26.6 mmol), Pd2dba3 (137 mg, 0.5 mmol) and 1,4-bis(diphenylphosphino)butane (128 mg, 0.30 mmol) were added. The reaction mixture was sealed and stirred for 1 h at room temperature and then concentrated. It was washed sequentially with 4N NaOH (2 x 50 mL) and water (50 mL), dried and concentrated to give a red oily material. This oily material was stirred with hexane (200 mL) for 10 min, the hexane layer was separated and concentrated to give the target product (3.0 g).MS (M + 1)+: 215.2.

References

[1] Patent: WO2017/3724, 2017, A1. Location in patent: Paragraph 00214

(S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE Suppliers

China 26 India 1 Switzerland 1 United Kingdom 2 United States 6 Global 36

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Amber MolTech LLC

Tel: 086-010-62176588
Fax: 086-010-62117849
Email: amber@jyamber.com
Country: China
ProdList: 10151
Advantage: 56

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Porse Fine Chemical Co.,LTD

Tel: 20-66003216 18666003216
Fax: +86-20-28069063
Email: info@porsefinechemical.com
Country: China
ProdList: 1941
Advantage: 62

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10123
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

191231-58-0, (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINERelated Search:

BOC-PRO-PSI(CH2NH)-GLY-OH N-(TERT-BUTOXYCARBONYL)-L-PROLINE N'-METHOXY-N'-METHYLAMIDE BOC-PRO-PRO-OH BOC-PRO-LEU-VAL-OME 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE BOC-PRO-D-PHE-OH BOC-PRO-PSI[CH2N(2-CL-Z)]-GLY-OH BOC-PRO-PNA Ditekiren BOC-PRO-PRO-PRO-PRO-OH BOC-PRO-GLY-OH BOC-PRO-PHE-OH (S)-1-BOC-2-[(2-BROMO-BENZYLAMINO)-METHYL]-PYRROLIDINE N-T-BOC-CIS-4-FLUORO-N-(1-CYANOCYCLOPROPYL)-L-PROLINAMIDE (1S,4S)-5-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE-2-CARBOXAMIDE (S)-1-BOC-2-[(3-BROMO-PHENYLAMINO)-METHYL]-PYRROLIDINE (S)-1-BOC-2-[(4-BROMO-PHENYLAMINO)-METHYL]-PYRROLIDINE (S)-1-BOC-2-[(3-BROMO-BENZYLAMINO)-METHYL]-PYRROLIDINE

(S)-N-methyl-1-(1-Bocpyrrolidin-2-yl)methanamine

(S)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate

tert-butyl (2S)-2-[(MethylaMino)Methyl]pyrrolidine-1-carboxylate

(S)-2-[(Methylamino)methyl]-1-pyrrolidinecarboxylic acid tert-butyl ester

(S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE

(S)-1-Boc-2-(N-methylaminomethyl)-pyrrolidine

1-Pyrrolidinecarboxylic acid, 2-[(methylamino)methyl]-, 1,1-dimethylethyl ester, (2S)-

tert-Butyl (S)-2-((methylamino)methyl)pyrrolidine-1-carboxylate

191231-58-0