Closantel

Description References

Product Name: Closantel
CAS No.: 57808-65-8
Chemical Name: Closantel
Synonyms: Zycloz;Diantel;R-31520;Closante;CLOSANTEL;faskoverm;5-diiodo-y-;iodobenzamide;CLOSANTEL BASE;Cyanoliodamide
CBNumber: CB5360606
Molecular Formula: C22H14Cl2I2N2O2
Formula Weight: 663.07
MOL File: 57808-65-8.mol

More

Less

Closantel Property

Melting point:: 217.8°
Boiling point:: 590.5±50.0 °C(Predicted)
Density: 1.8759 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
pka: 5.99±0.48(Predicted)
form: Solid
color: White to off-white
CAS DataBase Reference: 57808-65-8(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 2811
WGK Germany: 3
RTECS: CV2444250
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: A veterinary drug for the treatment of fluke and nematode infestations. In 1993, some was included in a batch of donated drugs sent to Lithuania. Attempts to match the product with the names of other medicines on accompanying literature resulted in its misidentification as a treatment for endometriosis. Eleven women lost their eyesight; though this has since returned, they were left with eye pain and are unable to work.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 34093
Product name: Closantel
Purity: PESTANAL
Packaging: 100mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 50mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 100mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 500mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 20531
Product name: Closantel
Purity: ≥98%
Packaging: 1g
Price: $547
Updated: 2024/03/01

More

Less

Closantel Chemical Properties,Usage,Production

Description

Closantel is a kind of synthetic anti parasitic agent which is actively against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Its mechanism of action is through decoupling the mitochondrial oxidative phosphorylation, thus inhibiting the production of ATP. Therefore, it inhibit their energy generation of the parasite, causing their death. It is mainly used for the treatment and prevention of several infections caused by many kinds of parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.

References

http://www.interchemie.com/veterinary-medicines/closan-50.html

Chemical Properties

White to light yellow powder

Uses

antianginal, antihypertensive

Definition

ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.

Closantel Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Closantel Suppliers

Brazil 1 China 186 China Hong Kong 1 Europe 2 France 1 Germany 3 India 25 Japan 2 Switzerland 2 United Kingdom 8 United States 29 Global 260

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19881
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

HBCChem Inc.

Tel: --
Fax: --
Email: sales@hbcchem-inc.com
Country: United States
ProdList: 4569
Advantage: 30

Selleck Chemicals LLC

Tel: --
Fax: --
Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

SHAMROCK INDUSTRIAL CO. LTD.

Tel: --
Fax: --
Email: pharma@shamrockindia.com
Country: United States
ProdList: 119
Advantage: 43

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Crescent Chemical Co., Inc.

Tel: --
Fax: --
Email: sales@creschem.com
Country: United States
ProdList: 4597
Advantage: 68

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

More

Less

View Lastest Price from Closantel manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Closantel 57808-65-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-27

Asia Chem I and E (Jiangsu) Co Ltd

Product: Closantel 57808-65-8
Price: US $300.00/kg
Min. Order: 1kg
Purity: 99.0%min
Supply Ability: 3tons/momth
Release date: 2024-12-30

Hebei Weibang Biotechnology Co., Ltd

Product: Closantel 57808-65-8
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-26

57808-65-8, ClosantelRelated Search:

CHLOROPHOSPHONAZO III Cyhalothrin Cyhalothrin Niclosamide ethanolamine salt Niclosamide theta-Cypermethrin BETA-CYPERMETHRIN Oxyclozanide 2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile 2-HYDROXY-5-IODO-BENZALDEHYDE 2-(2-Chlorophenyl)acetonitrile 3-Methylbenzyl cyanide 3,5-DIIODOSALICYLALDEHYDE Difluorochloromethane 3-Iodobenzylamine hydrochloride (4-AMINOPHENYL)PHENYLACETONITRILE HYDROCHLORIDE,97% 2-(4-aminophenyl)propiononitrile closantel sodium salt,CLOSANTEL SODIUM,CLOSANTEL(NA)

5-diiodo-y-

benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox

faskoverm

CLOSANTEL

CLOSANTEL BASE

N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE

n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid

iodobenzamide

n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-di

5'-CHLORO-4'-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODO-2'-METHYLSALICYLANILIDE

N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE

Benzamide, N-5-chloro-4-(4-chlorophenyl)cyanomethyl-2-methylphenyl-2-hydroxy-3,5-diiodo-

5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide

CLOSANTEL(PATENT)

N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL)

N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide

N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide

Diantel

N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

R-31520

Zycloz

5'-Chloro-.alpha.4-(p-chlorophenyl)-.alpha.4-cyano-3,5-diiodo-2',4'-salicyloxylidide

Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hy

Closantelfreebase

N-(5-Chloro-4-[(RS)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

Closante

Closantel Solution in Methanol/DMSO, 1000ug/mL

Cyanoliodamide

Closantel N-[5-chloor-4-[(4-chloorfenyl)-cyanomethyl]-2-methylfenyl]-2- hydroxy-3,5-di-joodbenzamide

Closantel in Methanol:DMSO=2:1

Closantel 100 μg/ml Acetonitrile

C11691500 Closantel

Chlorocyanine iodosamide

Closantel, 10 mM in DMSO

57808-65-8

57805-65-8

C22H14Cl2I2N2O2

COREG CR