3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
- Product Name
- 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
- CAS No.
- 85366-66-1
- Chemical Name
- 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE
- Synonyms
- 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE;Benzaldehyde, 3-bromo-4-(trifluoromethoxy)-;3-Bromo-4-(trifluoromethoxy)benzaldehyde98%;2-Bromo-4-formyl-alpha,alpha,alpha-trifluoroanisole
- CBNumber
- CB5361906
- Molecular Formula
- C8H4BrF3O2
- Formula Weight
- 269.02
- MOL File
- 85366-66-1.mol
3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- clear, faint yellow
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B678628
- Product name
- 3-Bromo-4-(trifluoromethoxy)benzaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B678628
- Product name
- 3-Bromo-4-(trifluoromethoxy)benzaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B678628
- Product name
- 3-Bromo-4-(trifluoromethoxy)benzaldehyde
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- PC1105
- Product name
- 3-Bromo-4-(trifluoromethoxy)benzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 2615-B-X2
- Product name
- 3-Bromo-4-(trifluoromethoxy)benzaldehyde
- Purity
- 99%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Chemical Properties,Usage,Production
Synthesis
659-28-9
85366-66-1
The general procedure for the synthesis of 3-bromo-4-(trifluoromethoxy)benzaldehyde from 4-trifluoromethoxybenzaldehyde was as follows: 68 g (0.36 mol) of 4-trifluoromethoxybenzaldehyde was dissolved in a mixture of 100 ml of dichloromethane, 100 ml of trifluoroacetic acid and 50 ml of concentrated sulfuric acid. The reaction mixture was stirred at room temperature and 130 g (0.72 mol) of N-bromosuccinimide was slowly added over 7 hours. After the addition was completed, the reaction mixture continued to be stirred at room temperature for 2 days. At the end of the reaction, the reaction mixture was poured into 1.2 liters of ice-water mixture. The aqueous phase was extracted three times with 500 ml of dichloromethane, the organic phases were combined and neutralized with 500 ml of saturated sodium bicarbonate solution. Subsequently, the organic phase was dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the organic solvent was removed by rotary evaporator under reduced pressure. To the residue, 500 ml of mixed n-pentane/ether (1:1) solvent was added and the precipitated succinimide was removed by filtration. The organic solvent was again removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (250 g, particle size 0.04-0.063 mm, Merck) using ethyl acetate/n-heptane (1:4) as mobile phase. Finally, 14 g of the target product was obtained. The product structure was confirmed by 1H-NMR (d6-DMSO, 600 MHz, δ ppm): 7.77 (d, J = 8.1 Hz, 1H), 8.05 (dd, J = 8.1 Hz, 1.7 Hz, 1H), 8.34 (d, J = 1.7 Hz, 1H), 10.01 (br s, 1H).
References
[1] Patent: US2003/144329, 2003, A1
[2] Patent: US2003/83357, 2003, A1
[3] Patent: US2003/105333, 2003, A1
[4] Patent: US6515003, 2003, B1
[5] Patent: WO2013/92756, 2013, A1. Location in patent: Page/Page column 52; 53
3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE manufacturers
- Product
- 3-BROMO-4-(TRIFLUOROMETHOXY)BENZALDEHYDE 85366-66-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-02-17