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FENOVERINE

Product Name
FENOVERINE
CAS No.
37561-27-6
Chemical Name
FENOVERINE
Synonyms
FENOVERINE;Spasmopriv;Fenoverine D8;3-chloro-3-oxopropanoic acid ethyl ester;10-[(4-Piperonyl-1-piperazinyl)acetyl]-10H-phenothiazine;Ethanone, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-1-(10H-phenothiazin-10-yl)-
CBNumber
CB5362347
Molecular Formula
C26H25N3O3S
Formula Weight
459.56
MOL File
37561-27-6.mol
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FENOVERINE Property

Melting point:
141-142°
Boiling point:
671.8±55.0 °C(Predicted)
Density 
1.343±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
6.47±0.10(Predicted)
form 
Solid
color 
Pale Beige to Beige
Stability:
Hygroscopic
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Safety

Toxicity
LD50 in mice (g/kg): ~1.50 orally, ~2.50 i.p. (Buzas, Pierre)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
F248898
Product name
Fenoverine
Packaging
50mg
Price
$95
Updated
2021/12/16
TRC
Product number
F248898
Product name
Fenoverine
Packaging
250mg
Price
$380
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0011437
Product name
FENOVERINE
Purity
95.00%
Packaging
5MG
Price
$500.9
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
18631
Product name
Fenoverine
Packaging
5mg
Price
$950
Updated
2021/12/16
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FENOVERINE Chemical Properties,Usage,Production

Originator

Spasmopriv,Paillusseau

Uses

Fenoverine is a colon-specific multi particulate drug. Also, it is an antispasmodic drug which inhibits contraction of smooth muscle. It is derived from Phenothiazine (P318040), which is a key component of antipsychotic and antihistaminic drugs.

Definition

ChEBI: Fenoverine is a member of phenothiazines.

Manufacturing Process

To a hot solution 199.3 g (0.1 mol) of phenothiazine in 2 L of dry benzene was added a little quantity of bromine and then were added dropwise 136 g (0.1 mol) of chloroacetyle chloride. Then a mixture was refluxed for 5 hours. After cooling the mixture was concentrated in vacuo. Product was dissolved at reflux in ethanol absolute and filtered. At room temperature was crystallized chloracetyl-10-phenothiazine with 123°C; yield 242 g.
A mixture of 13.8 g (0.05 mol) of chloracetyl-10-phenothiazine, 11.8 g (0.05 mol) of piperonyl-1-piperazine and 3.9 g (0.05 mol) of pyridine in 200 ml of dry toluene was refluxed for 3 hours. Then the solution was cooled and filtered. The filtrate was concentrated. The crystals of 10-((4-piperonyl-1- piperazinyl)acetyl)phenothiazine was recrystallized from isopropylic ether; M.P. 141-142°C; yield 67%.

Therapeutic Function

Spasmolytic

FENOVERINE Preparation Products And Raw materials

Raw materials

Preparation Products

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FENOVERINE Suppliers

ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47

37561-27-6, FENOVERINERelated Search:


  • FENOVERINE
  • 10-[(4-Piperonyl-1-piperazinyl)acetyl]-10H-phenothiazine
  • Spasmopriv
  • 3-chloro-3-oxopropanoic acid ethyl ester
  • Fenoverine D8
  • Ethanone, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-1-(10H-phenothiazin-10-yl)-
  • 37561-27-6
  • C26H25N3O3S