FENOVERINE Property

Melting point:

141-142°

Boiling point:

671.8±55.0 °C(Predicted)

Density 

1.343±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

6.47±0.10(Predicted)

form 

Solid

color 

Pale Beige to Beige

Stability:

Hygroscopic

Safety

Toxicity

LD50 in mice (g/kg): ~1.50 orally, ~2.50 i.p. (Buzas, Pierre)

Hazard and Precautionary Statements (GHS)

FENOVERINE Chemical Properties,Usage,Production

Originator

Spasmopriv,Paillusseau

Uses

Fenoverine is a colon-specific multi particulate drug. Also, it is an antispasmodic drug which inhibits contraction of smooth muscle. It is derived from Phenothiazine (P318040), which is a key component of antipsychotic and antihistaminic drugs.

Definition

ChEBI: Fenoverine is a member of phenothiazines.

Manufacturing Process

To a hot solution 199.3 g (0.1 mol) of phenothiazine in 2 L of dry benzene was added a little quantity of bromine and then were added dropwise 136 g (0.1 mol) of chloroacetyle chloride. Then a mixture was refluxed for 5 hours. After cooling the mixture was concentrated in vacuo. Product was dissolved at reflux in ethanol absolute and filtered. At room temperature was crystallized chloracetyl-10-phenothiazine with 123°C; yield 242 g.
A mixture of 13.8 g (0.05 mol) of chloracetyl-10-phenothiazine, 11.8 g (0.05 mol) of piperonyl-1-piperazine and 3.9 g (0.05 mol) of pyridine in 200 ml of dry toluene was refluxed for 3 hours. Then the solution was cooled and filtered. The filtrate was concentrated. The crystals of 10-((4-piperonyl-1- piperazinyl)acetyl)phenothiazine was recrystallized from isopropylic ether; M.P. 141-142°C; yield 67%.

Therapeutic Function

Spasmolytic