ChemicalBook > CAS DataBase List > SLU-PP-332

SLU-PP-332

Product Name
SLU-PP-332
CAS No.
303760-60-3
Chemical Name
SLU-PP-332
Synonyms
SLU-PP;SLU-PP-332;SLU-PP-332 5mg;Slu-pp-332 capsules 250mcg 100pcs;4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide;4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide;4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide,SLU-PP-332;4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide;Benzoic acid, 4-hydroxy-, 2-(2-naphthalenylmethylene)hydrazide;(E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide, SLU-PP-332
CBNumber
CB53644574
Molecular Formula
C18H14N2O2
Formula Weight
290.32
MOL File
303760-60-3.mol
More
Less

SLU-PP-332 Property

Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 2mg/mL, clear (Warmed)
pka
8.44±0.15(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)
InChIKey
RNZIMBFHRXYRLL-UHFFFAOYSA-N
SMILES
C(NN=CC1=CC=C2C(=C1)C=CC=C2)(=O)C1=CC=C(O)C=C1
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Aronis compounds
Product number
M01386
Product name
4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide
Packaging
5mg
Price
$15
Updated
2021/12/16
Aronis compounds
Product number
M01386
Product name
4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide
Packaging
50mg
Price
$50
Updated
2021/12/16
More
Less

SLU-PP-332 Chemical Properties,Usage,Production

Description

SLU-PP-332 is a synthetic estrogen receptor-related orphan receptor (ERR) agonist which activates an amplified aerobic exercise mode. SLU-PP-332 does not affect food intake, appetite, or exercise initiation. This agent improves a natural metabolic pathway that characteristically reacts to exercise, resulting in amplified energy expenditure and extra body fat metabolism. SLU-PP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an ERR target gene [pyruvate dehydrogenase kinase 4 (Pdk4)], and enhances mitochondrial respiration in C2C12 myocytes.

Uses

SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function[1].

benefits

SLU-PP-332 improves a natural metabolic route, which typically happens in response to exercise; it amplifies energy expenditure and results in faster body fat metabolism. SLU-PP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an ERR target gene [pyruvate dehydrogenase kinase 4 (Pdk4)], and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibres in skeletal muscle and improved exercise endurance in C57BL/6J mice. This drug works on a group of proteins throughout the body organs called ERRs that activate some of the most significant metabolic pathways in the body, including the cardiac cells and the brain tissue. The drug can potentially transform the future of fitness and can facilitate weight loss by stimulating the body’s muscles during exercise. The mechanism of action of SLU-PP-332 is to activate ERRs, leading to increased energy expenditure, fatty acid oxidation, and decreased fat mass accumulation.

in vivo

SLU-PP-332 (50 mg/kg, i.p., a single dose for 28 or 12 days) increases mitochondrial function and cellular respiration in a skeletal muscle cell line and induces an ERRα-specific acute aerobic exercise genetic program in mice[1].
SLU-PP-332 (50 mg/kg, i.p., twice per day for 28 days or 12 days) induces fatty acid metabolism, reduces fat mass and improves glucose metabolism in diet-induced obesity mouse models[3].

Animal Model:8-10 male C57BL/6J mice[1]
Dosage:50 mg/kg
Administration:i.p., a single dose for 28 or 12 days
Result:Displayed a more oxidative muscle phenotype, increased the complex I (NDUFB8) and complex V (ATP5A) protein expression in the gastrocnemius muscle and cytochrome C, mitochondria content and oxidative type IIa muscle fibers lavels in mice.
Animal Model:High fat diet-induced obesity mouse model[3]
Dosage:50 mg/kg
Administration:i.p., twice per day for 28 days or 12 days
Result:Did not alter brown adipose tissue mass, daily food intake and glucose metabolism, increased fatty acid oxidation (FAO) in normal in C57Bl/6 mice, but induced a progressive weight loss and decreased adipocytes size in high fat diet-induced obesity mouse models.

IC 50

ERRα: 98 nM (EC50); ERRβ: 230 nM (EC50); ERRγ: 430 nM (EC50)

References

[1] Nasri, Hamid. “New hopes on ‘SLU-PP-332’ as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view.” Journal of Renal Endocrinology 26 7 (2024).

SLU-PP-332 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SLU-PP-332 Suppliers

China 84 Russia 3 United States 1 Global 88
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7408
Advantage
58
Wuhan Yida Pharmaceutical Co., Ltd
Tel
+86-13401188533 +86-13476102740
Email
3451936732@qq.com
Country
China
ProdList
3
Advantage
58
Hubei Zhaoke BIO-CHEMICAL Co., Ltd.
Tel
18271904430 18271904430
Email
312523773@qq.com
Country
China
ProdList
217
Advantage
58
Xi'an Lyna Bio-Tech Co., Ltd.
Tel
+86-18629577295; 17709273212
Fax
029-84161958
Email
ludy@lynabio.com
Country
China
ProdList
1055
Advantage
55
Beijing Mesochem Technology Co., Ltd.
Tel
010-57862036 18811083386
Email
msales@mesochem.com
Country
China
ProdList
210
Advantage
58
Zhuhai Huachen Pharmaceutical Technology Co., Ltd
Tel
15916275916 18711182359;
Email
290113728@qq.com
Country
China
ProdList
36
Advantage
58
Yichang Chanod Biomedical Technology Co,LTD
Tel
0717-6855399 15377615856
Email
sales@sndswyy.cn
Country
China
ProdList
67
Advantage
58
Xiamen Weijian Yanfang Biotechnology Co., Ltd
Tel
13799798806
Email
sqx303@163.com
Country
China
ProdList
16
Advantage
58
Suzhou Myland Nutraceuticals Inc.
Tel
0086-512-6670 13382131678
Fax
0086-512-66700657
Email
jc@mylandpharm.com
Country
China
ProdList
60
Advantage
55
Wuhan Xinyan Biotechnology Co., Ltd.
Tel
027-17764015852 17764015852
Email
xinyanbioch@gmail.com
Country
China
ProdList
38
Advantage
58
More
Less

View Lastest Price from SLU-PP-332 manufacturers

Shandong Hanjiang Chemical Co., Ltd
Product
SLU-PP-332 303760-60-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2025-11-11
Shanghai Yimeixin Technology Co., LTD
Product
SLU-PP-332 303760-60-3
Price
US $0.00/box
Min. Order
1box
Purity
0.99
Supply Ability
10tons
Release date
2025-09-26
Hebei Lutong Import and Export Co., Ltd
Product
SLU-PP-332 303760-60-3
Price
US $100.00/mg
Min. Order
100mg
Purity
99.99%
Supply Ability
20t
Release date
2025-09-23

303760-60-3, SLU-PP-332Related Search:


  • 4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide
  • 4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide
  • Benzoic acid, 4-hydroxy-, 2-(2-naphthalenylmethylene)hydrazide
  • SLU-PP-332
  • SLU-PP
  • 4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
  • Slu-pp-332 capsules 250mcg 100pcs
  • (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide, SLU-PP-332
  • 4-hydroxy-N'-(2-naphthylmethylene)benzohydrazide,SLU-PP-332
  • SLU-PP-332 5mg
  • 303760-60-3