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(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt

Product Name
(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt
CAS No.
76204-02-9
Chemical Name
(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt
Synonyms
4-MU-NANA NA;NEU5AC-A-4MU;Neu5Ac-α-4MU;Neu5Ac-alpha-4MU;4MU-NeuNAc Sodium Salt;NEU5AC-ALPHA-4MU SODIUM SALT;2-(4-methylumbelliferyl)-A-D-N-*acetylneuraminic;2-(4-methylumbelliferyl)-α-D-N-*acetylneuraminic;Sodium 2-(4-methylumbelliferyl)-N-acetylneuraminate;2'-(4-METHYLUMBELLIFERYL)-A-D-N-*ACETYLN EURAMINIC A
CBNumber
CB5375725
Molecular Formula
C21H26NNaO11
Formula Weight
491.42
MOL File
76204-02-9.mol
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(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt Property

Melting point:
171°C dec.
storage temp. 
−20°C
solubility 
H2O: 50 mg/mL, clear, very slightly yellow
form 
Solid
color 
White to Off-White
Water Solubility 
water: 50mg/mL, clear to slightly hazy, colorless to light yellow
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Safety

Safety Statements 
24/25
WGK Germany 
3
F 
3-10
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
69587
Product name
2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate
Purity
BioReagent, suitable for fluorescence, ≥96.5% (HPLC)
Packaging
5mg
Price
$333
Updated
2025/07/31
Sigma-Aldrich
Product number
69587
Product name
2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate
Purity
BioReagent, suitable for fluorescence, ≥96.5% (HPLC)
Packaging
25mg
Price
$1113.75
Updated
2025/07/31
TCI Chemical
Product number
M3031
Product name
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic Acid Sodium Salt
Packaging
50MG
Price
$373
Updated
2025/07/31
Cayman Chemical
Product number
16620
Product name
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic Acid (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
16620
Product name
4-Methylumbelliferyl-N-acetyl-α-D-neuraminic Acid (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$101
Updated
2024/03/01
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(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt Chemical Properties,Usage,Production

Description

4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is a fluorogenic substrate of neuraminidases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus.

Chemical Properties

Off-White to Yellow Solid

Uses

Used as a substrate in a fluorometric assay of neuraminidase.

Uses

(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt has been used for fluorometric assay of neuraminidase as well as fluorescent staining of sialidases in PAGE.

Biochem/physiol Actions

Substrate for fluorometric assay of neuraminidase. Used for fluorescent staining of sialidases in PAGE.

References

[1] E MONTI. Expression of a novel human sialidase encoded by the NEU2 gene.[J]. Glycobiology, 1999, 9 12: 1313-1321. DOI: 10.1093/glycob/9.12.1313
[2] NICHOLAS M STAMATOS. Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.[J]. FEBS Journal, 2005, 272 10: 2545-2556. DOI: 10.1111/j.1742-4658.2005.04679.x
[3] ALAN S CROSS. NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not.[J]. The Journal of Biological Chemistry, 2012: 15966-15980. DOI: 10.1074/jbc.m112.346817
[4] N T WETHERALL. Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network.[J]. Journal of Clinical Microbiology, 2003, 41 2: 742-750. DOI: 10.1128/jcm.41.2.742-750.2003

(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt Suppliers

Canada 1 China 85 Europe 1 Germany 2 India 2 Japan 2 South Korea 1 Switzerland 4 United Kingdom 5 United States 17 Global 120
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt manufacturers

GlycoPharm.LLC
Product
Neu5Ac-a-4Mu 76204-02-9
Price
US $0.00/G
Min. Order
1G
Purity
97%HPLC
Supply Ability
MG-KG
Release date
2020-03-17
Career Henan Chemical Co
Product
2'-(4-METHYLUMBELLIFERYL)-ALPHA-D-N-ACETYLNEURAMINIC ACID SODIUM SALT 76204-02-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-22

76204-02-9, (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium saltRelated Search:

SODIUM 4-HYDROXYBUTYRATE Sodium octanoate 4-AMINOBUTYRALDEHYDE DIMETHYL ACETAL ENANTHIC ACID SODIUM SALT [(2-OXO-2H-CHROMEN-7-YL)OXY]ACETIC ACID Sodium lactate (4-METHYLPHENOXY)ACETIC ACID (R)-(+)-2-PHENOXYPROPIONIC ACID 3-METHOXYPHENOXYACETIC ACID 4-ETHYLPHENOXYACETIC ACID ACETALDEHYDE, PARA-METHYL PHENOXY PELARGONIC ACID SODIUM SALT Phenoxyacetic acid sodium salt 2-Hydroxycaprylic acid N-Acetylneuraminic acid (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt DL-2-HYDROXYVALERIC ACID SODIUM SALT 2-(4-ETHYLPHENOXY)PROPANOIC ACID

  • NEU5AC-A-4MU
  • NEU5AC-ALPHA-4MU SODIUM SALT
  • 2'-(4-METHYLUMBELLIFERYL)-A-D-N-ACETYLNEURAMINIC ACID, SODIUM SALT
  • 4-MU-NANA NA
  • 2-(4-methylumbelliferyl)-A-D-N-*acetylneuraminic
  • Sodium 2-(4-methylumbelliferyl)-N-acetylneuraminate
  • 4-methylumbelliferyl-N-acetyl-alpha-D-neuram.A.so-S.dihy.
  • 4-Methylumbelliferyl-N-acetyl-alpha-D-neuraminic acid sodium salt
  • 2'-(4-METHYLUMBELLIFERYL)-A-D-N-*ACETYLN EURAMINIC A
  • 2'-(4-METHYLUMBELLIFERYL)-A-D-N-ACETYLNEURAMINIC ACID SODIUM SALT HYDRATE
  • 2'-(4-methylumbelliferyl)-α-d-n-acetylneuraminic acid sodium salt hydrate
  • 4-methylumbelliferyl-n-acetyl-α-d-neuraminic acid sodium salt hydrate
  • 4-MethylumbelliferylN-acetyl-a-D-neuraminicacidsodiumsalt
  • 2'-(4-Methylumbelliferyl)-alpha-D-N-acetylneuraminic acid sodium salt hydrate
  • 4-methylumberiferryl-N-acetyl-alpha-D-neuraminic acid Na
  • 2μ-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid hydrate sodium salt
  • 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid hydrate sodium salt
  • N-Acetyl-2-O-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-alpha-neuraminic acid monosodium salt
  • 4-Methylumbelliferyl N-acetyl-α-D-neuraminic acid sodium salt
  • 4-Methylumbelliferyl N-acetyl-a-D-neuraminic acid sodium salt ,97%
  • 2-(4-methylumbelliferyl)-α-D-N-*acetylneuraminic
  • 4-Methylumbelliferyl-N-acetyl-a-D-neuraminic acid Sodium salt Dihydrate
  • Neu5Ac-α-4MU
  • 4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid sodium salt
  • 2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid
  • Neu5Ac-alpha-4MU
  • Sodium 4-Methyl-2-oxo-2H-chromen-7-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosidonate
  • (4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt USP/EP/BP
  • 2'-(4-Methylumbelliferyl)-a-D-N-acetylneuraminicacid sodiumsalt hydrate
  • 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic Acid, Sodium Salt
  • 2'-(4-Methylumbelliferyl)-Alpha-D-N-acetylneuraminic Acid Sodium Salt
  • 2’-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate
  • 2′-(4-Methylumbelliferyl)-α-<sc>D</sc>-<i>N</i>-acetylneuraminic acid sodium salt hydrate
  • 4MU-NeuNAc Sodium Salt
  • 2'-(4-Methylumbelliferyl)-Alpha-D-N-acetylneuraminic Acid, Sodium Salt
  • 76204-02-9
  • C21H24NNaO11xH2O
  • C21H24NO11種a
  • C21H24NNaO11
  • Biochemicals and Reagents
  • BioChemical
  • Alphabetical
  • Detection
  • Fluorescent Probes, Labels, Particles and Stains
  • Fluorescent Enzyme Substrates
  • substrate
  • Carbohydrates & Derivatives
  • Fluorescent Labels & Indicators