6-Hydroxypurine

ChemicalBook > CAS DataBase List > 6-Hydroxypurine

6-Hydroxypurine

Product Name: 6-Hydroxypurine
CAS No.: 68-94-0
Chemical Name: 6-Hydroxypurine
Synonyms: HYPOXANTHINE;9H-PURIN-6-OL;Hypoxanthine-d4;Hypoxanthine,99%;Hypoxanthine, 99.5%;3,7-dihydropurin-6-one;Azathioprine EP Impurity F;1,7-DIHYDRO-6H-PURIN-6-ONE;6H-Purin-6-one, 1,7-dihydro-;6H-Purin-6-one, 1,9-dihydro-
CBNumber: CB5378579
Molecular Formula: C5H4N4O
Formula Weight: 136.11
MOL File: 68-94-0.mol

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6-Hydroxypurine Property

Melting point:: >300 °C (lit.)
Boiling point:: 250.36°C (rough estimate)
Density: 1.4295 (rough estimate)
refractive index: 1.8500 (estimate)
storage temp.: 2-8°C
solubility: 1 M NaOH: 25 mg/mL
form: powder
pka: 8.7(at 25℃)
color: Colorless to yellow to brown, darken on storage with no loss of purity
Odor: Odorless
Water Solubility: practically insoluble
Merck: 14,4869
BRN: 5811
InChIKey: FDGQSTZJBFJUBT-UHFFFAOYSA-N
LogP: -0.910 (est)
CAS DataBase Reference: 68-94-0(CAS DataBase Reference)
NIST Chemistry Reference: Hypoxanthine(68-94-0)
EPA Substance Registry System: Hypoxanthine (68-94-0)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22-40
Safety Statements: 22-24/25-37/39-26-36
WGK Germany: 3
RTECS: UP0791000
Hazard Note: Harmful
TSCA: Yes
HS Code: 29335990
Toxicity: LD50 intraperitoneal in mouse: 750mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002147
Product name: Mercaptopurine impurity A
Purity: CRS, European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002147
Price: $156
Updated: 2024/03/01

Sigma-Aldrich

Product number: 4010CBC
Product name: Hypoxanthine - CAS 68-94-0 - Calbiochem
Purity: Xanthine oxidase substrate.
Packaging: 25g
Price: $97.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1191226
Product name: Didanosine Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1490
Updated: 2024/03/01

TCI Chemical

Product number: H0311
Product name: Hypoxanthine
Purity: >98.0%(HPLC)(E)
Packaging: 5g
Price: $25
Updated: 2024/03/01

TCI Chemical

Product number: H0311
Product name: Hypoxanthine
Purity: >98.0%(HPLC)(E)
Packaging: 25g
Price: $70
Updated: 2024/03/01

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6-Hydroxypurine Chemical Properties,Usage,Production

Description

Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.

Chemical Properties

White to off-white powder

Uses

A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals

Uses

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Uses

Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol ? (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.

Definition

ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.

General Description

Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).

Biochem/physiol Actions

Hypoxanthine?is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.

Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of Nox

Purification Methods

Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]

6-Hydroxypurine Preparation Products And Raw materials

Raw materials

Sodium ethoxide 6-Aminothiouracil Ethyl cyanoacetate Thiourea

Preparation Products

6-Dimethylaminopurine 6-N-HEPTYLMERCAPTOPURINE Adenine 6-Mercaptopurine 6-N-HEXYLAMINOPURINE 6-ETHOXYPURINE 6-CYANOPURINE 6-benzylaminopurine 6-ETHYLMERCAPTOPURINE Acyclovir 6-Bromopurine 6-Mercaptopurine monohydrate 6-N-BUTOXYPURINE 6-Iodopurine 6-benzylaminopurine hydrochloride

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View Lastest Price from 6-Hydroxypurine manufacturers

airuikechemical co., ltd.

Product: 6-Hydroxypurine 68-94-0
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 2000tons
Release date: 2024-04-08

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: 6-Hydroxypurine 68-94-0
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-10-21

Hebei Duling International Trade Co. LTD

Product: Hypoxanthine 68-94-0
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-03-15

68-94-0, 6-HydroxypurineRelated Search:

6-Mercaptopurine disulfide GUANERAN Ethanone, 1-[6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purin-9-yl]- 8-Methyl-7H-purin-6-ol 9H-Purine, 9-β-D-arabinofuranosyl-6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- 1H-Imidazol-5-amine,1-methyl-4-nitro-(9CI) 4,5-Dichloroimidazole 1,7-DIHYDRO-2-METHYL-6-PURINONE Azathioprine EP Impurity E Azathioprine EP Impurity D 1-METHYL-2,4,5-TRICHLOROIMIDAZOLE 2-Chloro-1-methyl-1H-imidazole 1-Methyl-4-Chloroimidazole 4,5-DICHLORO-1-METHYLIMIDAZOLE 5-Chloro-1-methylimidazole (Z)-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylic acid Disodium 5'-Inosinate Theophylline monohydrate

Hypoxanthine,99%

HYPOXANTHINE ANHYDROUS

Hypoxanthine, 99.5%

Hypoxanthinee

3,7-dihydropurin-6-one

HYPOXANTHINE(RG)

6-HYDROXYPURINE(HYPOXANTHINE)

purine-6(1H)-one

Hypexanthine

6-oxypurine

HYPOXANTHINE extrapure

HYPOXANTHINE (Hyp)

Didanosine Related CoMpound A

Didanosine Related Compound A (25 mg) (Hypoxanthine)

Hypoxanthine, 99.5% 25GR

Hypoxanthine, 99.5% 5GR

1,9-Dihydro-

Hypoxanthine API

Hypoxanthine ,98%

6(1H)-PURINONE

9H-PURIN-6-OL

HYPOXANTHINE CELL CULTURE TESTED

HYPOXANTHINE 99%

HypoxanthineForBiochemistry

HypoxanthineForBiochemistry99%

HYPOXANTHINE FOR BIOCHEMISTRY 99%

6H-Purin-6-one, 1,7-dihydro- (9CI)

1,7-dihydro-6h-purin-6-on

1,7-Dihydro-6H-purine-6-one

AKOS BBS-00002144

3H-Purin-6-ol

4-Hydroxy-1H-purine

6H-Purin-6-one, 1,7-dihydro-

6-Hydropurine

6-Hydroxy-1H-purine

6-Oxopurine

7H-Purin-6-ol

9H-Purin-6(1H)-one

1H-Purin-6(9H)-one

6H-Purin-6-one, 1,9-dihydro-

Hypoxanthine Vetec(TM) reagent grade, 98%

1H-Purin-6(7H)-one

Hypoxanthine, Animal-Free

Hypoxsanthine (1,7-Dihydro-6H-purin-6-one)

Azathioprine EP Impurity F

hypoxanthineenol

Hypoxathine

Purin-6(3H)-one

Purine-6-ol

Sarkine

Purin-6(1H)-one

PURIN-6-OL

SARCINE

SARKIN

TTGGTTGGGTGGTHGGTGTTGGGG

TIMTEC-BB SBB004203

IFLAB-BB F1386-0269

HYPOXANTHINE