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6-Hydroxypurine

Product Name
6-Hydroxypurine
CAS No.
68-94-0
Chemical Name
6-Hydroxypurine
Synonyms
HYPOXANTHINE;9H-PURIN-6-OL;Hypoxanthine-d4;Hypoxanthine,99%;Hypoxanthine, 99.5%;3,7-dihydropurin-6-one;Azathioprine EP Impurity F;1,7-DIHYDRO-6H-PURIN-6-ONE;6H-Purin-6-one, 1,7-dihydro-;6H-Purin-6-one, 1,9-dihydro-
CBNumber
CB5378579
Molecular Formula
C5H4N4O
Formula Weight
136.11
MOL File
68-94-0.mol
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6-Hydroxypurine Property

Melting point:
>300 °C (lit.)
Boiling point:
250.36°C (rough estimate)
Density 
1.4295 (rough estimate)
refractive index 
1.8500 (estimate)
storage temp. 
2-8°C
solubility 
1 M NaOH: 25 mg/mL
form 
powder
pka
8.7(at 25℃)
color 
Colorless to yellow to brown, darken on storage with no loss of purity
Odor
Odorless
Water Solubility 
practically insoluble
Merck 
14,4869
BRN 
5811
InChIKey
FDGQSTZJBFJUBT-UHFFFAOYSA-N
LogP
-0.910 (est)
CAS DataBase Reference
68-94-0(CAS DataBase Reference)
NIST Chemistry Reference
Hypoxanthine(68-94-0)
EPA Substance Registry System
Hypoxanthine (68-94-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22-40
Safety Statements 
22-24/25-37/39-26-36
WGK Germany 
3
RTECS 
UP0791000
Hazard Note 
Harmful
TSCA 
Yes
HS Code 
29335990
Toxicity
LD50 intraperitoneal in mouse: 750mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002147
Product name
Mercaptopurine impurity A
Purity
CRS, European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002147
Price
$156
Updated
2024/03/01
Sigma-Aldrich
Product number
4010CBC
Product name
Hypoxanthine - CAS 68-94-0 - Calbiochem
Purity
Xanthine oxidase substrate.
Packaging
25g
Price
$97.6
Updated
2024/03/01
Sigma-Aldrich
Product number
1191226
Product name
Didanosine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1490
Updated
2024/03/01
TCI Chemical
Product number
H0311
Product name
Hypoxanthine
Purity
>98.0%(HPLC)(E)
Packaging
5g
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
H0311
Product name
Hypoxanthine
Purity
>98.0%(HPLC)(E)
Packaging
25g
Price
$70
Updated
2024/03/01
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6-Hydroxypurine Chemical Properties,Usage,Production

Description

Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.

Chemical Properties

White to off-white powder

Uses

A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals

Uses

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Uses

Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol ? (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.

Definition

ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.

General Description

Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).

Biochem/physiol Actions

Hypoxanthine?is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.

Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of Nox

Purification Methods

Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]

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View Lastest Price from 6-Hydroxypurine manufacturers

airuikechemical co., ltd.
Product
6-Hydroxypurine 68-94-0
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
2000tons
Release date
2024-03-26
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
6-Hydroxypurine 68-94-0
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-21
Hebei Duling International Trade Co. LTD
Product
Hypoxanthine 68-94-0
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-03-15

68-94-0, 6-HydroxypurineRelated Search:


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