4-CHLORO-3-METHYLBENZALDEHYDE
- Product Name
- 4-CHLORO-3-METHYLBENZALDEHYDE
- CAS No.
- 101349-71-7
- Chemical Name
- 4-CHLORO-3-METHYLBENZALDEHYDE
- Synonyms
- 4-CHLORO-3-METHYLBENZALDEHYDE;Benzaldehyde, 4-chloro-3-Methyl-;a-Chloro-3,5-difluoroacetophenone
- CBNumber
- CB5380480
- Molecular Formula
- C8H7ClO
- Formula Weight
- 154.59
- MOL File
- 101349-71-7.mol
4-CHLORO-3-METHYLBENZALDEHYDE Property
- Melting point:
- 27-28°C
- Boiling point:
- 115°C 27mm
- Density
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to light yellow Solid
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-51-41-37/38
- Safety Statements
- 26-36/37/39-39
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C367795
- Product name
- 4-Chloro-3-methylbenzaldehyde
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- C367795
- Product name
- 4-Chloro-3-methylbenzaldehyde
- Packaging
- 10g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 022358
- Product name
- 4-Chloro-3-methylbenzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- Y3523
- Product name
- 4-Chloro-3-methylbenzaldehyde
- Packaging
- 1g
- Price
- $117
- Updated
- 2021/12/16
- Product number
- FC149317
- Product name
- 4-Chloro-3-methylbenzaldehyde
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
4-CHLORO-3-METHYLBENZALDEHYDE Chemical Properties,Usage,Production
Uses
4-Chloro-3-methylbenzaldehyde is a reactant used in the preparation of pyrrolidine Ureas as C-C chemokine receptor 1 (CCR1) antagonists.
Synthesis
4403-61-6
101349-71-7
1) Synthesis of intermediate A33-2: Phosphorus oxychloride (POCl3, 18.3 mL, 200 mmol) was added to a 100 mL two-necked flask and stirred 100 times. 2-Methyl-2-butenenitrile (A33-1, 10.43 g, 70%, 90 mmol) was dissolved in N,N-dimethylformamide (DMF, 15.4 mL, 200 mmol) and slowly added dropwise to the above solution. After the dropwise addition, the reaction was stirred at 110°C for 24 hours. After the reaction was completed, it was cooled to room temperature and the reaction mixture was slowly diluted with dichloromethane (100 mL) and then poured into ice water. The aqueous phase was extracted with dichloromethane (100 mL x 3), the organic phases were combined and washed with water. The organic phase was then washed with saturated saline (200 mL x 3), dried over anhydrous sodium sulfate, filtered to remove the desiccant, and the solvent was removed by rotary evaporation. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=10:1) to give a white solid product (2.9 g, 21% yield).
References
[1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0246; 0247; 0248
4-CHLORO-3-METHYLBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-3-METHYLBENZALDEHYDE manufacturers
- Product
- 4-Chloro-3-methylbenzaldehyde 101349-71-7
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 4-Chloro-3-methylbenzaldehyde 101349-71-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 4-CHLORO-3-METHYLBENZALDEHYDE 101349-71-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2018-12-25