ChemicalBook > CAS DataBase List > 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE

4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE

Product Name: 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
CAS No.: 216163-53-0
Chemical Name: 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
Synonyms: PD 174265;PD 174265, 10 mM in DMSO;PD 174265 - CAS 216163-53-0 - Calbiochem;PD 174265, EGFR tyrosine kinase inhibitor;N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide;4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE;N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide;Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-
CBNumber: CB5381265
Molecular Formula: C17H15BrN4O
Formula Weight: 371.23
MOL File: 216163-53-0.mol

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4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Property

storage temp.: -20°C
solubility: DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
form: Yellow solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 513040-M
Product name: PD 174265
Purity: A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 450 pM).
Packaging: 1 unit
Price: $145
Updated: 2025/07/31

Cayman Chemical

Product number: 17649
Product name: PD 174265
Purity: ≥98%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 17649
Product name: PD 174265
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 17649
Product name: PD 174265
Purity: ≥98%
Packaging: 5mg
Price: $469
Updated: 2024/03/01

TRC

Product number: P218333
Product name: PD174265
Packaging: 2.5mg
Price: $240
Updated: 2021/12/16

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4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Chemical Properties,Usage,Production

Description

PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC₅₀ = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC₅₀s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity.

Uses

PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity.

General Description

A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).

Biochem/physiol Actions

Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity

Enzyme inhibitor

This substituted quinazoline (FWfree-base = 371.24 g/mol), also known as 4- [(3-bromophenyl)amino]-6-propionylamidoquinazoline, inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.45 nM. PD 174265 selectively targets and irreversibly inactivates the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a Cys-773. See also PD 168393

References

[1] D W FRY. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1998, 95 20: 12022-12027. DOI: 10.1073/pnas.95.20.12022

4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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216163-53-0, 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINERelated Search:

PD 174265 6-Quinazolinamine (9CI) N4-(3-BROMO-PHENYL)-QUINAZOLINE-4,6-DIAMINE

PD 174265

4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE

N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide

PD 174265 - CAS 216163-53-0 - Calbiochem

Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-

N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide

PD 174265, EGFR tyrosine kinase inhibitor

PD 174265, 10 mM in DMSO

216163-53-0