ChemicalBook > CAS DataBase List > 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE

4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE

Product Name
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
CAS No.
216163-53-0
Chemical Name
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
Synonyms
PD 174265;PD 174265 - CAS 216163-53-0 - Calbiochem;N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide;4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE;N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide;Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-
CBNumber
CB5381265
Molecular Formula
C17H15BrN4O
Formula Weight
371.23
MOL File
216163-53-0.mol
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4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Property

storage temp. 
-20°C
solubility 
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
form 
Yellow solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17649
Product name
PD 174265
Purity
≥98%
Packaging
500μg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
17649
Product name
PD 174265
Purity
≥98%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
17649
Product name
PD 174265
Purity
≥98%
Packaging
5mg
Price
$469
Updated
2024/03/01
TRC
Product number
P218333
Product name
PD174265
Packaging
2.5mg
Price
$240
Updated
2021/12/16
TRC
Product number
P218333
Product name
PD174265
Packaging
1mg
Price
$120
Updated
2021/12/16
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4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Chemical Properties,Usage,Production

Description

PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity.

Uses

PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity.

General Description

A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).

Biochem/physiol Actions

Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity

Enzyme inhibitor

This substituted quinazoline (FWfree-base = 371.24 g/mol), also known as 4- [(3-bromophenyl)amino]-6-propionylamidoquinazoline, inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.45 nM. PD 174265 selectively targets and irreversibly inactivates the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a Cys-773. See also PD 168393

4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Suppliers

China 45 Italy 1 Japan 1 Switzerland 1 United Kingdom 1 United States 6 USA 1 Global 56
Vinci-Biochem
Tel
--
Fax
--
Email
vb@vincibiochem.it
Country
Italy
ProdList
115
Advantage
58

216163-53-0, 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINERelated Search:

PD 174265 6-Quinazolinamine (9CI) N4-(3-BROMO-PHENYL)-QUINAZOLINE-4,6-DIAMINE

  • PD 174265
  • 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
  • N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide
  • PD 174265 - CAS 216163-53-0 - Calbiochem
  • Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-
  • N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide
  • 216163-53-0