2-(AMMONIOOXY)PROPANE CHLORIDE
- Product Name
- 2-(AMMONIOOXY)PROPANE CHLORIDE
- CAS No.
- 4490-81-7
- Chemical Name
- 2-(AMMONIOOXY)PROPANE CHLORIDE
- Synonyms
- 2-(AMMONIOOXY)PROPANE CHLORIDE;N-Isopropoxyamine hydrochloride;2-(AMINOOXY)PROPANE HYDROCHLORIDE;ISOPROPYL HYDROXYAMIN HYDROCHLORIDE;Isopropylhydroxylaminehydrochloride;O-Isopropylhydroxylamine hydrochloride;2-(aminooxy)propane hydrochloride 98%+;O-propan-2-ylhydroxylamine hydrochloride;O-(1-Methylethyl)hydroxylamine hydrochloride;HydroxylaMine, O-(1-Methylethyl)-, hydrochloride
- CBNumber
- CB5389584
- Molecular Formula
- C3H10ClNO
- Formula Weight
- 111.57
- MOL File
- 4490-81-7.mol
2-(AMMONIOOXY)PROPANE CHLORIDE Property
- Melting point:
- 94-96°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- RIDADR
- UN3261
- HazardClass
- IRRITANT
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A618900
- Product name
- 2-(Aminooxy)propaneHydrochloride
- Packaging
- 25g
- Price
- $715
- Updated
- 2021/12/16
- Product number
- FA63546
- Product name
- 2-(Aminooxy)propane hydrochloride
- Packaging
- 1g
- Price
- $520
- Updated
- 2021/12/16
- Product number
- 043224
- Product name
- 2-(Aminooxy)propane hydrochloride
- Purity
- >95%
- Packaging
- 5g
- Price
- $699
- Updated
- 2021/12/16
- Product number
- J54904
- Product name
- O-Isopropylhydroxylaminehydrochloride
- Packaging
- 25g
- Price
- $880
- Updated
- 2021/12/16
- Product number
- FA63546
- Product name
- 2-(Aminooxy)propane hydrochloride
- Packaging
- 2g
- Price
- $1000
- Updated
- 2021/12/16
2-(AMMONIOOXY)PROPANE CHLORIDE Chemical Properties,Usage,Production
Uses
2-(Aminooxy)propane Hydrochloride, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It can be utilized for the synthesis of Dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases.
Synthesis
51951-27-0
4490-81-7
General procedure for the synthesis of isopropylhydroxylamine hydrochloride from 2-isopropoxyisodihydroindole-1,3-dione: Hydrazine monohydrate (2.80 mL, 58.5 mmol) was added to a chloroform solution (100 mL) of N-(isopropoxy)phthalimide (4.00 g, 19.5 mmol) containing 10% methanol, and the reaction was stirred for 47 hours at room temperature. After completion of the reaction, the reaction mixture was filtered under reduced pressure and the filtrate was concentrated under vacuum. To the resulting crude product was added diethyl ether, followed by dropwise addition of 1,4-dioxane solution of hydrogen chloride (4 mol/L) until the pH reached 3. The precipitated solid was collected to afford O-isopropylhydroxylamine hydrochloride as a white solid (0.77 g, 35% yield).
References
[1] Journal of Antibiotics, 2000, vol. 53, # 10, p. 1071 - 1085
[2] Patent: WO2012/74999, 2012, A1. Location in patent: Page/Page column 91
[3] Patent: US2008/146625, 2008, A1. Location in patent: Page/Page column 9
[4] Patent: JP2015/848, 2015, A. Location in patent: Paragraph 0148; 0149; 0151
[5] Patent: US2014/378399, 2014, A1. Location in patent: Paragraph 0104
2-(AMMONIOOXY)PROPANE CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(AMMONIOOXY)PROPANE CHLORIDE manufacturers
- Product
- 2-(AMMONIOOXY)PROPANE CHLORIDE 4490-81-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04