1-Boc-4-methanesulfonyloxypiperidine
- Product Name
- 1-Boc-4-methanesulfonyloxypiperidine
- CAS No.
- 141699-59-4
- Chemical Name
- 1-Boc-4-methanesulfonyloxypiperidine
- Synonyms
- tert-butyl4-(Methylsulfonyloxy)piperidine-1-carboxylate;tert-butyl 4-(methanesulfonyloxy)piperidine-1-carboxylate;4-METHANESULFONYLOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Crizotinib Impurity 12;)oxy)piperidine-1-carboxyL;1-Boc-methanesulfonyl-piperdine;1-Boc-4-methanesulfonyloxy-piper;L-Valine,6-mercapto-,methylester;1-BOC-4-METHANESULFONYLOXY-PIPERIDINE;N-BOC-4-(methanesulfonyloxy)piperidine
- CBNumber
- CB5391495
- Molecular Formula
- C11H21NO5S
- Formula Weight
- 279.35
- MOL File
- 141699-59-4.mol
1-Boc-4-methanesulfonyloxypiperidine Property
- Melting point:
- 193-195 °C
- Boiling point:
- 407.2±34.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- -3.02±0.40(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C11H21NO5S/c1-11(2,3)16-10(13)12-7-5-9(6-8-12)17-18(4,14)15/h9H,5-8H2,1-4H3
- InChIKey
- WOEQSXAIPTXOPY-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(OS(C)(=O)=O)CC1
- CAS DataBase Reference
- 141699-59-4(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-20/21/22
- Safety Statements
- 45-24/25-23
- RIDADR
- 2811
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B4353
- Product name
- 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- B4353
- Product name
- 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $260
- Updated
- 2025/07/31
- Product number
- M287603
- Product name
- 4-Methanesulfonyloxy-piperidine-1-carboxylicAcidtert-ButylEster
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J91083
- Product name
- 4-Methanesulfonyloxy-piperidine-1-carboxylicacidtert-butylester
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK479869
- Product name
- 1-Boc-4-methanesulfonyloxy-piperidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
1-Boc-4-methanesulfonyloxypiperidine Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
4-Methanesulfonyloxy-piperidine-1-carboxylic Acid tert-Butyl Ester is a useful research chemical used in the preparation of (aminoaryl)(benzyloxy)pyridines as potential antitumor agents.
Synthesis
124-63-0
109384-19-2
141699-59-4
N-Boc-4-hydroxypiperidine (10 g, 49.68 mmol, 1 eq.) and triethylamine (7.54 g, 74.50 mmol, 1.5 eq., 10.38 ml) were dissolved in anhydrous dichloromethane (200 ml) and cooled to 0-5 °C. Methylsulfonyl chloride (6.88 g, 60.12 mmol, 4.65 ml, 1.21 eq.) was added slowly and dropwise under stirring. The reaction mixture was stirred at 0-5 °C for 3 hours. After completion of the reaction, the mixture was diluted with dichloromethane (200 ml), transferred to a separatory funnel and washed sequentially with 2M aqueous sodium carbonate solution (200 ml) and saturated sodium chloride solution (200 ml). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 14.51 g of tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate as a white solid (yield = 100%). The product was confirmed by 1H-NMR (400 MHz, DMSO-d6) and mass spectrometry (EI): δ 4.80 (m, 1H), 3.39 (m, 2H), 3.29 (m, 2H), 2.94 (s, 3H), 1.77 (m, 2H), 1.52 (m, 2H); MS (EI): 280 (MH+).
References
[1] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 174-175
[2] Patent: WO2010/138490, 2010, A1. Location in patent: Page/Page column 28
[3] Patent: WO2010/138487, 2010, A1. Location in patent: Page/Page column 122
[4] Patent: US2011/152243, 2011, A1. Location in patent: Page/Page column 96
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 12, p. 4092 - 4108
1-Boc-4-methanesulfonyloxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-4-methanesulfonyloxypiperidine Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
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- 23653
- Advantage
- 75
View Lastest Price from 1-Boc-4-methanesulfonyloxypiperidine manufacturers
- Product
- tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate 141699-59-4
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 1-Boc-4-methanesulfonyloxypiperidine 141699-59-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-Boc-4-methanesulfonyloxypiperidine 141699-59-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-08