ChemicalBook > CAS DataBase List > 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE

6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE

Product Name
6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE
CAS No.
22190-35-8
Chemical Name
6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE
Synonyms
TIMTEC-BB SBB013968;UKRORGSYN-BB BBV-052938;6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE;quinoline, 6-bromo-1,2,3,4-tetrahydro-;6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE，97% min;6-broMo-1,2,3,4-tetrahydroquinoline hydrocholide;6-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HCL 6-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE
CBNumber
CB5391516
Molecular Formula
C9H10BrN
Formula Weight
212.09
MOL File
22190-35-8.mol
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6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE Property

Boiling point:
303.1±31.0 °C(Predicted)
Density 
1.428±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
4.26±0.20(Predicted)
form 
low melting solid
color 
Light yellow to brown
InChI
InChI=1S/C9H10BrN/c10-8-3-4-9-7(6-8)2-1-5-11-9/h3-4,6,11H,1-2,5H2
InChIKey
WEHMHBSITKCQBY-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(Br)C=C2)CCC1
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Safety

HazardClass 
IRRITANT
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B415483
Product name
6-Bromo-1,2,3,4-tetrahydroquinoline
Packaging
50mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
3H31-9-03
Product name
6-Bromo-1,2,3,4-tetrahydroquinoline
Purity
95%
Packaging
100mg
Price
$40
Updated
2021/12/16
SynQuest Laboratories
Product number
3H31-9-03
Product name
6-Bromo-1,2,3,4-tetrahydroquinoline
Purity
95%
Packaging
250mg
Price
$85
Updated
2021/12/16
Matrix Scientific
Product number
057237
Product name
6-Bromo-1,2,3,4-tetrahydroquinoline
Purity
95%
Packaging
1g
Price
$87
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB42083
Product name
6-Bromo-1,2,3,4-tetrahydroquinoline
Packaging
500mg
Price
$100
Updated
2021/12/16
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6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE Chemical Properties,Usage,Production

Synthesis

635-46-1

22190-35-8

General steps: 1. Bromination reaction: To a stirred acetonitrile solution of 1,2,3,4-tetrahydroquinoline (20.0 g, 150 mmol, 1.0 eq.) was added N-bromosuccinimide (25.5 g, 143 mmol, 0.95 eq.) in 4 portions at 0°C, each 20 minutes apart. The reaction mixture was continued to be stirred for 3 h at 0 °C. 2. Reaction monitoring: the progress of the reaction was monitored by thin layer chromatography (TLC), the unfolding agent was 10% ethyl acetate-hexane and the product Rf value was 0.55. 3. Post-treatment: After completion of the reaction, the organic layer was diluted with the addition of ether and washed sequentially with saturated sodium bicarbonate solution, water and brine. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. 4. Purification: The crude product was purified by column chromatography on silica gel (100-200 mesh) with hexane solution of 5% ethyl acetate as eluent to give 6-bromo-1,2,3,4-tetrahydroquinoline (20.0 g, 64% yield) as a yellow oil. 5. Characterization of the product: Liquid chromatography-mass spectrometry (LCMS) analysis showed a purity of 92.25% (ES+): m/z 212.0 (M+H+); retention time (tr) = 2.06 min.

References

[1] Tetrahedron, 2005, vol. 61, # 16, p. 4035 - 4041
[2] Patent: WO2012/94462, 2012, A2. Location in patent: Page/Page column 60
[3] Patent: US2008/221160, 2008, A1. Location in patent: Page/Page column 11; 12
[4] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 11
[5] Patent: WO2013/166015, 2013, A1. Location in patent: Paragraph 0093 - 0095

6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE Suppliers

China 141 Finland 1 India 3 Russia 1 Ukraine 1 United Kingdom 3 United States 9 Global 159
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View Lastest Price from 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE manufacturers

Career Henan Chemical Co
Product
6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE 22190-35-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-03

22190-35-8, 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINERelated Search:

6-bromo-2,3,4,9-tetrahydro-1H-carbazole 6-bromo-1,2,3,4-tetrahydroisoquinoline 6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 6-Bromo-2,3-Dihydroquinolin-4(1H)-One 6-BROMO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 6-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER 6-BROMO-3,4-DIHYDRO-4,4-DIMETHYLQUINOLIN-2(1H)-ONE 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE 9-BROMO-2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLINE 1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline 6-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE-3-CARBOXYLIC ACID AURORA KA-4644 ASISCHEM N57875 AURORA KA-4057 AURORA KA-4056 4(1H)-Quinolinone, 6-bromo-2,3-dihydro-1-(1-oxopropyl)-, 4-oxime ASISCHEM N57876 1(2H)-Quinolinecarboxamide, 6-bromo-3,4-dihydro-4-(hydroxyimino)-N-met hyl-

  • 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE
  • TIMTEC-BB SBB013968
  • UKRORGSYN-BB BBV-052938
  • quinoline, 6-bromo-1,2,3,4-tetrahydro-
  • 6-broMo-1,2,3,4-tetrahydroquinoline hydrocholide
  • 6-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HCL 6-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE
  • 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE，97% min
  • 22190-35-8