METHYL 2-(2-AMINO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE

METHYL 2-(2-AMINO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE Property

Melting point:

111-113°C

Boiling point:

313.1±22.0 °C(Predicted)

Density 

1.283±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

3.08±0.10(Predicted)

Appearance

Light yellow to yellow Solid

InChI

InChI=1S/C7H10N2O2S/c1-3-11-6(10)5-4(2)12-7(8)9-5/h3H2,1-2H3,(H2,8,9)

InChIKey

KTGUPAFUVGHOQS-UHFFFAOYSA-N

SMILES

S1C(C)=C(C(OCC)=O)N=C1N

Safety

HazardClass 

IRRITANT

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

METHYL 2-(2-AMINO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE Chemical Properties,Usage,Production

Synthesis

Step 2: Synthesis of ethyl 2-amino-5-methylthiazole-4-carboxylate Thiourea (47 g, 616.83 mmol) was added to a solution of ethyl 2-chloro-3-oxobutanoate (100 g, 577.19 mmol) in ethanol (1000 mL). The resulting mixture was stirred and reacted under reflux conditions for 2 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature in a water/ice bath. The precipitate was collected by filtration to give 105 g (93% yield) of ethyl 2-amino-5-methylthiazole-4-carboxylate as a light yellow solid.

References

[1] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 51