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DM4-Sme

Product Name
DM4-Sme
CAS No.
796073-68-2
Chemical Name
DM4-Sme
Synonyms
DM4-Sme;Maytansinoid DM4 Impurity 1;Maytansinoid DM4 Impurity 1-d6;Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-
CBNumber
CB53959872
Molecular Formula
C39H56ClN3O10S2
Formula Weight
826.46
MOL File
796073-68-2.mol
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DM4-Sme Property

Boiling point:
963.8±65.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
9.82±0.70(Predicted)
InChIKey
LTLNAIFGVAUBEJ-GPEBISKRNA-N
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0104947
Product name
DM4-SMe
Purity
≥98.0%
Packaging
5mg
Price
$495
Updated
2021/12/16
ChemScene
Product number
CS-0104947
Product name
DM4-SMe
Purity
≥98.0%
Packaging
10mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0104947
Product name
DM4-SMe
Purity
≥98.0%
Packaging
25mg
Price
$1550
Updated
2021/12/16
ChemScene
Product number
CS-0104947
Product name
DM4-SMe
Purity
≥98.0%
Packaging
50mg
Price
$2550
Updated
2021/12/16
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DM4-Sme Chemical Properties,Usage,Production

Description

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].

References

[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. [2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

DM4-Sme Preparation Products And Raw materials

Raw materials

Preparation Products

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DM4-Sme Suppliers

Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19743
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
Jinan blalong chemical co. LTD
Tel
2710913286@.com
Email
1513643261@qq.com
Country
China
ProdList
14253
Advantage
58
Shanghai Zerui Biotechnology Co., Ltd.
Tel
021-54580889 18321124657
Fax
021-54580889
Email
731997554@qq.com
Country
China
ProdList
10614
Advantage
58
Henan Vcommend Consultrading Co., Ltd.
Tel
13393721940
Email
sales@vcommend.com
Country
China
ProdList
9965
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58

796073-68-2, DM4-SmeRelated Search:


  • DM4-Sme
  • Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-
  • Maytansinoid DM4 Impurity 1
  • Maytansinoid DM4 Impurity 1-d6
  • 796073-68-2