DM4-Sme
- Product Name
- DM4-Sme
- CAS No.
- 796073-68-2
- Chemical Name
- DM4-Sme
- Synonyms
- DM4-Sme;Maytansinoid DM4 Impurity 1;Maytansinoid DM4 Impurity 1-d6;Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-;(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(4-methyl-4-(methyldisulfaneyl)pentanoyl)-L-alaninate
- CBNumber
- CB53959872
- Molecular Formula
- C39H56ClN3O10S2
- Formula Weight
- 826.46
- MOL File
- 796073-68-2.mol
DM4-Sme Property
- Boiling point:
- 963.8±65.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 9.82±0.70(Predicted)
- color
- White to off-white
- InChIKey
- LTLNAIFGVAUBEJ-GPEBISKRNA-N
N-Bromosuccinimide Price
- Product number
- CS-0104947
- Product name
- DM4-SMe
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- CS-0104947
- Product name
- DM4-SMe
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CS-0104947
- Product name
- DM4-SMe
- Purity
- ≥98.0%
- Packaging
- 25mg
- Price
- $1550
- Updated
- 2021/12/16
- Product number
- CS-0104947
- Product name
- DM4-SMe
- Purity
- ≥98.0%
- Packaging
- 50mg
- Price
- $2550
- Updated
- 2021/12/16
DM4-Sme Chemical Properties,Usage,Production
Description
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].
Uses
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].
IC 50
Maytansinoids
References
[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. [2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).
DM4-Sme Preparation Products And Raw materials
Raw materials
Preparation Products
DM4-Sme Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
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- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
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- tp@aladdinsci.com
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- United States
- ProdList
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