EBI-2511
- Product Name
- EBI-2511
- CAS No.
- 2098546-05-3
- Chemical Name
- EBI-2511
- Synonyms
- EBI-2511;EBI-2511;EBI2511;EBI 2511;;Histone Methyltransferase,Inhibitor,EBI-2511,inhibit,EBI 2511,EBI2511;N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethyl-6-[ethyl(oxan-4-yl)amino]-2-(1-propan-2-ylpiperidin-4-yl)-1-benzofuran-4-carboxamide;N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-ethyl-6-[ethyl(oxan-4-yl)amino]-2-[1-(propan-2-yl)piperidin-4-yl]-1-benzofuran-4-carboxamide;4-Benzofurancarboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-ethyl-6-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2-[1-(1-methylethyl)-4-piperidinyl]-
- CBNumber
- CB53960140
- Molecular Formula
- C34H48N4O4
- Formula Weight
- 576.77
- MOL File
- 2098546-05-3.mol
EBI-2511 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 5 mg/mL (8.67 mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0040564
- Product name
- EBI-2511
- Purity
- 99.38%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-0040564
- Product name
- EBI-2511
- Purity
- 99.38%
- Packaging
- 10mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- CS-0040564
- Product name
- EBI-2511
- Purity
- 99.38%
- Packaging
- 25mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- CS-0040564
- Product name
- EBI-2511
- Purity
- 99.38%
- Packaging
- 50mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0040564
- Product name
- EBI-2511
- Purity
- 99.38%
- Packaging
- 100mg
- Price
- $1350
- Updated
- 2021/12/16
EBI-2511 Chemical Properties,Usage,Production
Uses
EBI-2511 is a highly potent and orally active EZH2 inhibitor, with an IC50 of 6 nM in Pfeffiera cell lines, respectively.
in vivo
EBI-2511 displays a dose-dependent inhibition on the tumor growth, resulting in 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg) reduction in tumor size. At the same dosage level, EBI-2511 shows a superior anti-tumor efficacy to EPZ-6438 (P<0.01). It is noteworthy that no significant changes in body weights of all treatment groups are observed[1].
IC 50
EZH2
References
[1] Lu B, et al. Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102. DOI:10.1021/acsmedchemlett.7b00437
EBI-2511 Preparation Products And Raw materials
Raw materials
Preparation Products
EBI-2511 Suppliers
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- 16314854226
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- Country
- United States
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- tp@aladdinsci.com
- Country
- United States
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View Lastest Price from EBI-2511 manufacturers
- Product
- EBI-2511 2098546-05-3
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-09-16