(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE

Uses

Product Name: (R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE
CAS No.: 149524-42-5
Chemical Name: (R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE
Synonyms: Tedizolid Impurity 33;Trozolamide impurity 46;(5R)-3-(3-Fluorophenyl)-5-hydroxymethyloxazolidin-2-one;(R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)-2-oxazolidinone;(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE;(5R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)-2-oxazolidinone;2-Oxazolidinone, 3-(3-fluorophenyl)-5-(hydroxyMethyl)-, (5R)-;(5R)-3-(3-fluorophenyl)-5-(hydroxyMethyl)-1,3-oxazolidin-2-one;Tedizolid Impurity 1: (R) -3- (3-fluorophenyl) -5-hydroxymethyloxazolidin-2-one
CBNumber: CB5396162
Molecular Formula: C10H10FNO3
Formula Weight: 211.19
MOL File: 149524-42-5.mol

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(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE Property

Boiling point:: 341.2±25.0 °C(Predicted)
Density: 1.368±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.05±0.10(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F594230
Product name: (R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
Packaging: 25mg
Price: $85
Updated: 2021/12/16

TRC

Product number: F594230
Product name: (R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
Packaging: 100mg
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0031165
Product name: (R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE
Purity: 95.00%
Packaging: 250MG
Price: $263.55
Updated: 2021/12/16

Matrix Scientific

Product number: 074036
Product name: (R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)-oxazolidin-2-one
Purity: 95+%
Packaging: 250mg
Price: $297
Updated: 2021/12/16

Activate Scientific

Product number: AS32263
Product name: (R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
Purity: 97+% ee
Packaging: 1g
Price: $308
Updated: 2021/12/16

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(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE Chemical Properties,Usage,Production

Uses

(R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one is a five-membered heterocyclic compound containing oxygen and nitrogen atoms. It can be used as a pharmaceutical intermediate for pharmaceutical synthesis and experimental research.

Synthesis

60456-26-0

149524-47-0

149524-42-5

GENERAL METHOD: Benzyl (3-fluorophenyl)carbamate (2 mmol) was dissolved in anhydrous THF (10 mL) and cooled to -78 °C under nitrogen protection. Subsequently, a THF solution of 1 M LHMDS (1.7 mL, 1.7 mmol) was slowly added over 20 min. After stirring the reaction mixture at -78 °C for 1 h, (R)-(-)-glycidyl butyrate (0.24 g, 1.7 mmol) was added dropwise and stirring was continued at this temperature. Next, the reaction mixture was allowed to gradually warm up to room temperature over a period of 1 hour with stirring and stirring was continued for 12 hours. Upon completion of the reaction, the reaction was quenched with deionized water (10 mL) and EtOAc (4 mL) was added. The organic and aqueous layers were separated and the aqueous layer was extracted with EtOAc (3 x 10 mL). The organic extracts were combined, washed with saturated aqueous sodium chloride solution (3 × 5 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuum. The crude product was dissolved in DCM (10 mL) and left overnight to precipitate a white precipitate, filtered and washed with DCM.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 23, p. 5310 - 5321
[2] European Journal of Medicinal Chemistry, 2011, vol. 46, # 4, p. 1027 - 1039
[3] Patent: CN106146559, 2016, A. Location in patent: Paragraph 0044; 0045
[4] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 9, p. 1009 - 1014
[5] Patent: US2010/234615, 2010, A1. Location in patent: Page/Page column 36

(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE Suppliers

China 79 Germany 1 India 2 United States 13 Global 95

A.J Chemicals

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Email: sales@ajchem.in
Country: India
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View Lastest Price from (R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE manufacturers

Career Henan Chemical Co

Product: (R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE 149524-42-5
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

149524-42-5, (R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONERelated Search:

bis(((R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl) hydrogen phosphate Tedizolid Impurity 32 Tedizolid Impurity 36 (S)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one Tedizolid IMpurity Tedizolid Impurity 39 (S)-(+)-Glycidyl butyrate Tedizolid Impurity 36 Torezolid 2-(1-methyltetrazol-5-yl)pyridine (R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl) phenyl)-2-oxooxazolidin-5-yl)methyl butyrate (R)-Glycidyl butyrate (R)-3-(4-(6-(1H-tetrazol-5-yl)pyridin-3-yl)-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one Tedizolid phosphate impurity 5-Bromo-2-pyridinecarbonitrile ((R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl trihydrogen diphosphate 6,6'-bis(2-methyl-2H-tetrazol-5-yl)-3,3'-bipyridine (R)-5-(2-fluoro-4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl) phenyl)-2-(2-methyl-2H-tetrazol-5-yl)pyridine 1-oxide

(R)-3-(3-FLUOROPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE

(5R)-3-(3-fluorophenyl)-5-(hydroxyMethyl)-1,3-oxazolidin-2-one

2-Oxazolidinone, 3-(3-fluorophenyl)-5-(hydroxyMethyl)-, (5R)-

(5R)-3-(3-Fluorophenyl)-5-hydroxymethyloxazolidin-2-one

Tedizolid Impurity 1: (R) -3- (3-fluorophenyl) -5-hydroxymethyloxazolidin-2-one

Tedizolid Impurity 33

(R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)-2-oxazolidinone

Trozolamide impurity 46

(5R)-3-(3-Fluorophenyl)-5-(hydroxymethyl)-2-oxazolidinone

149524-42-5

pharmacetical

Intermediates