ChemicalBook > CAS DataBase List > 1-ACETYL-3-THIOSEMICARBAZIDE

1-ACETYL-3-THIOSEMICARBAZIDE

Product Name: 1-ACETYL-3-THIOSEMICARBAZIDE
CAS No.: 2302-88-7
Chemical Name: 1-ACETYL-3-THIOSEMICARBAZIDE
Synonyms: acetamidothiourea;ACETYLTHIOSEMICARBAZIDE;1-ACETYLTHIOSEMICARBAZIDE;1-ACETYL-3-THIOSEMICARBAZIDE;1-Acetylthiosemicarbazide,95%;2-acetylhydrazinecarbothioaMide;N-{[Thio(carbonoimidyl)]amino}acetamide;Acetic acid, 2-(aminothioxomethyl)hydrazide;Acetic acid N'-(aminothioxomethyl) hydrazide
CBNumber: CB5400203
Molecular Formula: C3H7N3OS
Formula Weight: 133.17
MOL File: 2302-88-7.mol

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1-ACETYL-3-THIOSEMICARBAZIDE Property

Melting point:: 165-170 °C
Density: 1.280 (estimate)
refractive index: 1.7490 (estimate)
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Sparingly), Methanol (Sparingly)
pka: 10.30±0.70(Predicted)
form: solid
Appearance: Off-white to light yellow Solid
Water Solubility: Partly soluble in water.
Stability:: Hygroscopic
CAS DataBase Reference: 2302-88-7(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 24/25-45
RIDADR: 2811
HazardClass: 6.1
PackingGroup: III
HS Code: 29309099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

TRC

Product number: B642518
Product name: N-{[Thio(carbonoimidyl)]amino}acetamide
Packaging: 1g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA160492
Product name: 1-Acetyl-3-thiosemicarbazide
Packaging: 10g
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA160492
Product name: 1-Acetyl-3-thiosemicarbazide
Packaging: 25g
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA160492
Product name: 1-Acetyl-3-thiosemicarbazide
Packaging: 50g
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 133062
Product name: 2-Acetylhydrazinecarbothioamide
Purity: 97%
Packaging: 25g
Price: $233
Updated: 2021/12/16

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1-ACETYL-3-THIOSEMICARBAZIDE Chemical Properties,Usage,Production

Chemical Properties

white to slightly beige crystalline powder

Uses

1-Acetyl-3-thiosemicarbazide is applied in pharmaceutical industry as an intermediate.

Synthesis

79-19-6

75-36-5

2302-88-7

General procedure for the synthesis of acetylthiosemicarbazone from aminothiourea and acetyl chloride: preparation of the intermediate 2-acetylcarbazinethioformamide; Acetyl chloride (8.64 g, 0.11 mol) was added slowly and dropwise to an anhydrous tetrahydrofuran (THF, 100 mL) solution of aminothiourea (9.10 g, 0.10 mol) at 0 °C. The reaction mixture was heated to reflux and maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of water (100 mL) followed by extraction with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent: methanol/dichloromethane=1/1, v/v) to afford the target compound acetylthiosemicarbazone (8.64 g, 65% yield). The results of mass spectrometry (electrospray ionization, ESI) analysis: m/z calculated value C3H7N3OS [M+H]+ 133.03, measured value 134.0 (MH+).

References

[1] Patent: WO2009/87220, 2009, A1. Location in patent: Page/Page column 57
[2] Yakugaku Zasshi, 1952, vol. 72, p. 376
[3] Chem.Abstr., 1953, p. 3856
[4] Synthetic Communications, 2004, vol. 34, # 22, p. 4189 - 4198
[5] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2010, vol. 76, # 5, p. 531 - 536

1-ACETYL-3-THIOSEMICARBAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ACETYL-3-THIOSEMICARBAZIDE Suppliers

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2302-88-7, 1-ACETYL-3-THIOSEMICARBAZIDERelated Search:

ACETOXYPROPYLTRIMETHOXYSILANE Acetohydroxamic acid Acetoxyacetyl chloride Ethyl acetohydroxamate AC-GLY-OSU 1-Cyclohexylethan-1-one 5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE 1-ACETYL-3-THIOSEMICARBAZIDE Thiourea Semicarbazide N-Aminothiourea 1-BENZOYL-4-PHENYL-3-THIOSEMICARBAZIDE TIMTEC-BB SBB000384 ASISCHEM D38724 4-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-1-(2-THIENYLCARBONYL)THIOSEMICARBAZIDE 2-(2-CHLOROBENZOYL)-N-(2,6-DIMETHYLPHENYL)HYDRAZINECARBOTHIOAMIDE BUTTPARK 58\40-78 4-(4-METHOXYPHENYL)-1-(3,4,5-TRIMETHOXYBENZOYL)THIOSEMICARBAZIDE

ACETYLTHIOSEMICARBAZIDE

acetamidothiourea

1-ACETYLTHIOSEMICARBAZIDE

1-ACETYL-3-THIOSEMICARBAZIDE

Acetic acid N'-(aminothioxomethyl) hydrazide

1-Acetylthiosemicarbazide,95%

2-acetylhydrazinecarbothioaMide

Acetic acid, 2-(aminothioxomethyl)hydrazide

N-{[Thio(carbonoimidyl)]amino}acetamide

2302-88-7

C3H7N3OS

H2NCSNHNHCOCH3

Sulphur Derivatives