Acetohydroxamic acid
- Product Name
- Acetohydroxamic acid
- CAS No.
- 546-88-3
- Chemical Name
- Acetohydroxamic acid
- Synonyms
- AHA;N-HYDROXYACETAMIDE;Acetylhydroxamic acid;Acetomenadione;Acetylhydroxylamine;NSC 5073;Lithostat;yangwosuan;NSC 176136;NSC 408425
- CBNumber
- CB6395344
- Molecular Formula
- C2H5NO2
- Formula Weight
- 75.07
- MOL File
- 546-88-3.mol
Acetohydroxamic acid Property
- Melting point:
- 88-90 °C (lit.)
- Boiling point:
- 133.7°C (rough estimate)
- Density
- 1.2269 (rough estimate)
- refractive index
- 1.4264 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Methanol (Sparingly), Water (Sparingly)
- form
- Crystalline Solid
- pka
- 8.70(at 25℃)
- color
- White to pale yellow
- Water Solubility
- Soluble in water.
- Sensitive
- Hygroscopic
- Merck
- 14,63
- BRN
- 1739019
- Stability:
- Moisture and Temperature Sensitive
- InChIKey
- RRUDCFGSUDOHDG-UHFFFAOYSA-N
- CAS DataBase Reference
- 546-88-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetamide,N-hydroxy(546-88-3)
- EPA Substance Registry System
- Acetohydroxamic acid (546-88-3)
Safety
- Hazard Codes
- T
- Risk Statements
- 61-40
- Safety Statements
- 53-45-36/37/39-22
- RIDADR
- 3263
- WGK Germany
- 3
- RTECS
- AK8157000
- Hazard Note
- Toxic
- PackingGroup
- II
- HS Code
- 29225090
- Hazardous Substances Data
- 546-88-3(Hazardous Substances Data)
- Toxicity
- mmo-sat 160 mmol/plate JOPHDQ 3,557,80
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 159034
- Product name
- Acetohydroxamic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $66.3
- Updated
- 2024/03/01
- Product number
- 1006506
- Product name
- Acetohydroxamic acid
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $412
- Updated
- 2024/03/01
- Product number
- A0051
- Product name
- Acetohydroxamic Acid
- Purity
- >98.0%(T)
- Packaging
- 10g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- A0051
- Product name
- Acetohydroxamic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 23979
- Product name
- Acetohydroxamic Acid
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $32
- Updated
- 2024/03/01
Acetohydroxamic acid Chemical Properties,Usage,Production
Description
Acetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.
Chemical Properties
White Crystalline Solid
Originator
Research Organics; Baylor Unk. (USA)
Uses
Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.
Acetohydroxamic acid was used:
to study the mechanism of complexation of iron (III) with acetohydroxamic acid.
to study the inhibitory mechanism of lansoprazole and omeprazole on Helicobacter pyloni.
in urease inhibition studies.
for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.
Used in urease inhibition studies and for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.
Uses
A urease inhibitor. Used in the synthesis
Uses
Urease inhibitorAcetohydroxamic acid acts as a drug, as an inhibitor of bacterial and plant urease, which is used for urinary tract infections. It is also used in organic synthesis. It acts as an antiurolithic and antibacterial agent. It is involved in the study of complexation of iron(III) with acetohydroxamic acid as well as in the inhibition study of lansoprazole and omeprazole on Helicobacter pyloni. It plays an important role in the insitu generation of nitrosocarbonylmethane as a Diels-Alder dienophile. In addition to this, it is used in the treatment of kidney stones and urinary tract infections.
Definition
ChEBI: Acetohydroxamic acid is a member of the class of acetohydroxamic acids that is acetamide in which one of the amino hydrogens has been replaced by a hydroxy group. It has a role as an EC 3.5.1.5 (urease) inhibitor and an algal metabolite. It is functionally related to an acetamide. It is a tautomer of a N-hydroxyacetimidic acid.
Manufacturing Process
3 Methods of producing of acetohydroxamic acid:
1. Ethyl acetic acid ether was treated with hydroxylamine and
acetohydroxamic acid was obtained.
2. Acetohydroxamic acid was obtained in the result of reaction of acetamide
with hydroxylamine.
3. Acetohydroxamic acid was obtained by treatment of acetaldehyde with
nitrohydroxylamine.
brand name
Lithostat (Mission).
Therapeutic Function
Urease inhibitor
General Description
Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.
Side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pounding heartbeats or fluttering in your chest;
signs of a blood clot in your leg --pain, swelling, warmth, or redness in one or both legs;
signs of a red blood cell disorder --pale or yellowed skin, dark colored urine, fever, confusion or weakness.
Common side effects may include:
headache during the first 2 days of treatment;
skin rash, warmth, tingling or redness (especially if you drink alcohol while taking acetohydroxamic acid);
upset stomach, nausea, loss of appetite;
depressed mood;
anxiety, tremors, nervousness;
hair loss.
Safety Profile
Moderately toxic by intraperitonealroute. An experimental teratogen. Other experimentalreproductive effects. Mutation data reported. When heatedto decomposition it emits toxic fumes of NOx.
Veterinary Drugs and Treatments
Acetohydroxamic acid can be used in dogs as adjunctive therapy in some cases of recurrent urolithiasis or in the treatment of persistent urinary tract infections caused by the following bacteria: E. coli, Klebsiella, Morganella morganii, Staphylococci spp., and Pseudomonas aeruginosa. Adverse effects limit its usefulness.
Acetohydroxamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acetohydroxamic acid manufacturers
- Product
- Acetohydroxamic Acid 546-88-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 10 tons
- Release date
- 2024-03-19
- Product
- Acetohydroxamic acid 546-88-3
- Price
- US $20.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-07
- Product
- Acetohydroxamic acid 546-88-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-02-03