Benzohydroxamic acid
- Product Name
- Benzohydroxamic acid
- CAS No.
- 495-18-1
- Chemical Name
- Benzohydroxamic acid
- Synonyms
- BHAM;NSC 3136;NSC 147248;benzohydroxamate;Benzohydroxamsαure;N-HYDROXYBENZAMIDE;n-hydroxy-benzamid;BENZOHYROXAMICACID;benzohydroxamicaci;BENZHYDROXAMIC ACID
- CBNumber
- CB4764830
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 495-18-1.mol
Benzohydroxamic acid Property
- Melting point:
- 126-130 °C(lit.)
- Boiling point:
- 251.96°C (rough estimate)
- Density
- 1.2528 (rough estimate)
- refractive index
- 1.5030 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in alcohol. Slightly soluble in ether. Insoluble in benzene.
- pka
- pK1: 8.89(0) (20°C)
- form
- Solid
- color
- Rhombic tablets
- Water Solubility
- 22 g/L (6 ºC)
- BRN
- 1907585
- Stability:
- Moisture and Temperature Sensitive
- InChIKey
- VDEUYMSGMPQMIK-UHFFFAOYSA-N
- CAS DataBase Reference
- 495-18-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzamide, n-hydroxy-(495-18-1)
- EPA Substance Registry System
- Benzohydroxamic acid (495-18-1)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 68-40-20/21/22
- Safety Statements
- 45-36/37-36-22
- WGK Germany
- 3
- RTECS
- DF9650000
- TSCA
- Yes
- HS Code
- 29280090
- Toxicity
- LD orl-rat: >500 mg/kg NCNSA6 5,26,53
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 412260
- Product name
- Benzhydroxamic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $76.6
- Updated
- 2024/03/01
- Product number
- B0061
- Product name
- Benzohydroxamic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $36
- Updated
- 2024/03/01
- Product number
- B0061
- Product name
- Benzohydroxamic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $143
- Updated
- 2024/03/01
- Product number
- A10509
- Product name
- Benzohydroxamic acid, 98%
- Packaging
- 10g
- Price
- $80.2
- Updated
- 2024/03/01
- Product number
- A10509
- Product name
- Benzohydroxamic acid, 98%
- Packaging
- 25g
- Price
- $166
- Updated
- 2024/03/01
Benzohydroxamic acid Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Uses
Benzhydroxamic acid is used as precursor in the synthesis of novel mono-anionic and di-anionic hydroxamato complexes by reacting with BiPh3 and Bi(O(t)Bu)3, which has anti-bacterial activity against helicobacter pylori. It is used in the photometric determination of trace amounts of vanadium in alloy steels by making mixed-ligand vanadium chelates with ammonium thiocyanate. It is also involved in the palladium catalyzed synthesis of benzisoxazolones.
Uses
Benzhydroxamic acid may be employed for the Pd-catalyzed synthesis of benzisoxazolones.
Preparation
To a rapidly stirred suspension of 19.6 gm (0.35 mole) of powdered anhydrous potassium hydroxide in 120 ml of pyridine, maintained at 0-5°C, is a added a solution of 13.9 gm (0.2 mole) of hydroxylamine hydrochloride in 100 ml of pyridine.
While maintaining the reaction temperature at 0-5°C, 15 gm (0.1 mole) of ethyl benzoate is added. Vigorous stirring is continued at room temperature for 6 hr. Then the solids are filtered off. The solids are washed with cold water to remove inorganic coproducts. The remainder, recrystallized from aqueous ethanol, represents a 94% yield of potassium benzohydroxamate.
This salt is triturated with cold 0.01 TV hydrochloric acid. From this mixture, by the usual procedures, 12.5 gm (91% overall) of benzohydroxamic acid is isolated, m.p. 131°C (from aqueous alcohol).
Synthesis Reference(s)
Tetrahedron Letters, 33, p. 5055, 1992 DOI: 10.1016/S0040-4039(00)61187-5
General Description
Rhombic crystals or light beige solid.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
Benzohydroxamic acid is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzohydroxamic acid emits toxic fumes of nitrogen oxides.
Fire Hazard
Flash point data for Benzohydroxamic acid are not available; however, Benzohydroxamic acid is probably combustible.
Safety Profile
Moderately toxic by ingestion.Mutation data reported. When heated to decomposition itemits toxic fumes of NOx.
Benzohydroxamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzohydroxamic acid manufacturers
- Product
- Benzohydroxamic acid 495-18-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- Benzohydroxamic acid 495-18-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-09-13
- Product
- Benzohydroxamic acid 495-18-1
- Price
- US $5.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-12