ChemicalBook > CAS DataBase List > Benzohydroxamic acid

Benzohydroxamic acid

Product Name
Benzohydroxamic acid
CAS No.
495-18-1
Chemical Name
Benzohydroxamic acid
Synonyms
BHAM;NSC 3136;NSC 147248;benzohydroxamate;Benzohydroxamsαure;N-HYDROXYBENZAMIDE;n-hydroxy-benzamid;BENZOHYROXAMICACID;benzohydroxamicaci;BENZHYDROXAMIC ACID
CBNumber
CB4764830
Molecular Formula
C7H7NO2
Formula Weight
137.14
MOL File
495-18-1.mol
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Benzohydroxamic acid Property

Melting point:
126-130 °C(lit.)
Boiling point:
251.96°C (rough estimate)
Density 
1.2528 (rough estimate)
refractive index 
1.5030 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in alcohol. Slightly soluble in ether. Insoluble in benzene.
pka
pK1: 8.89(0) (20°C)
form 
Solid
color 
Rhombic tablets
Water Solubility 
22 g/L (6 ºC)
BRN 
1907585
Stability:
Moisture and Temperature Sensitive
InChIKey
VDEUYMSGMPQMIK-UHFFFAOYSA-N
CAS DataBase Reference
495-18-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzamide, n-hydroxy-(495-18-1)
EPA Substance Registry System
Benzohydroxamic acid (495-18-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
68-40-20/21/22
Safety Statements 
45-36/37-36-22
WGK Germany 
3
RTECS 
DF9650000
TSCA 
Yes
HS Code 
29280090
Toxicity
LD orl-rat: >500 mg/kg NCNSA6 5,26,53
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
412260
Product name
Benzhydroxamic acid
Purity
99%
Packaging
5g
Price
$76.6
Updated
2024/03/01
TCI Chemical
Product number
B0061
Product name
Benzohydroxamic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
B0061
Product name
Benzohydroxamic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$143
Updated
2024/03/01
Alfa Aesar
Product number
A10509
Product name
Benzohydroxamic acid, 98%
Packaging
10g
Price
$80.2
Updated
2024/03/01
Alfa Aesar
Product number
A10509
Product name
Benzohydroxamic acid, 98%
Packaging
25g
Price
$166
Updated
2024/03/01
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Benzohydroxamic acid Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Benzhydroxamic acid is used as precursor in the synthesis of novel mono-anionic and di-anionic hydroxamato complexes by reacting with BiPh3 and Bi(O(t)Bu)3, which has anti-bacterial activity against helicobacter pylori. It is used in the photometric determination of trace amounts of vanadium in alloy steels by making mixed-ligand vanadium chelates with ammonium thiocyanate. It is also involved in the palladium catalyzed synthesis of benzisoxazolones.

Uses

Benzhydroxamic acid may be employed for the Pd-catalyzed synthesis of benzisoxazolones.

Preparation

To a rapidly stirred suspension of 19.6 gm (0.35 mole) of powdered anhydrous potassium hydroxide in 120 ml of pyridine, maintained at 0-5°C, is a added a solution of 13.9 gm (0.2 mole) of hydroxylamine hy­drochloride in 100 ml of pyridine.
While maintaining the reaction temperature at 0-5°C, 15 gm (0.1 mole) of ethyl benzoate is added. Vigorous stirring is continued at room tempera­ture for 6 hr. Then the solids are filtered off. The solids are washed with cold water to remove inorganic coproducts. The remainder, recrystallized from aqueous ethanol, represents a 94% yield of potassium benzohy­droxamate.
This salt is triturated with cold 0.01 TV hydrochloric acid. From this mixture, by the usual procedures, 12.5 gm (91% overall) of benzohydrox­amic acid is isolated, m.p. 131°C (from aqueous alcohol).

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 5055, 1992 DOI: 10.1016/S0040-4039(00)61187-5

General Description

Rhombic crystals or light beige solid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Benzohydroxamic acid is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzohydroxamic acid emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for Benzohydroxamic acid are not available; however, Benzohydroxamic acid is probably combustible.

Safety Profile

Moderately toxic by ingestion.Mutation data reported. When heated to decomposition itemits toxic fumes of NOx.

Benzohydroxamic acid Preparation Products And Raw materials

Raw materials

Sodium chloride Ethyl acetate Hydrochloric acid Methanol Sodium hydroxide Hydroxylamine hydrochloride Hydroxylamine sulfate Methyl benzoate Ethyl benzoate

Preparation Products

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View Lastest Price from Benzohydroxamic acid manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Benzohydroxamic acid 495-18-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-13
Hebei Weibang Biotechnology Co., Ltd
Product
Benzohydroxamic acid 495-18-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-26
Hebei Weibang Biotechnology Co., Ltd
Product
Benzohydroxamic acid 495-18-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

495-18-1, Benzohydroxamic acidRelated Search:

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  • 495-18-1
  • C7H7NO2
  • Hydroxylamines (N-Substituted)
  • Hydroxylamines
  • Organic Building Blocks
  • Nitrogen Compounds
  • C7
  • Carbonyl Compounds
  • Carboxylic Acids
  • Building Blocks
  • Aromatics
  • AMIDE
  • Hydroxylamines
  • Hydroxylamines (N-Substituted)
  • Inhibitors