17BETA-ESTRADIOL, CYCLODEXTRIN-ENCAPSULATED Property

solubility 

H₂O: 25 mg/mL, may be clear to slightly hazy

Safety

Hazard Codes 

T

Risk Statements 

60-61-64-40-63

Safety Statements 

53-45-36/37

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H351Suspected of causing cancer

H362May cause harm to breast-fed children

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

17BETA-ESTRADIOL, CYCLODEXTRIN-ENCAPSULATED Chemical Properties,Usage,Production

Uses

β-estradiol has been used:

• to culture differentiated adipocytes
• for estradiol treatment in rats
• for oocyte maturation in vitro

β-Estradiol is used to study cell differentiation and transformations (tumorigenicity). This product is not recommended for use in binding assays.

General Description

β-estradiol is a natural human?estrogen. It is vital for the growth of breast and reproductive epithelia, maturation of long bones and development of secondary sexual characteristics. Estradiol is produced by immature germ cells, spermatozoa, Leydig cells and Sertoli cells. β-estradiol acts as a menopausal hormones. It is involved in replacement therapy for female hypogonadism or primary ovarian failure. Reduced levels of β-estradiol are linked to heart disease and osteoporosis. Estradiol plays a critical role in proliferation, modulation of ion transport and control of apoptosis in Sertoli cells. It maintains sperm concentration, motility and morphology.