4-Aminopyridine-2-carboxylic acid

Product Name: 4-Aminopyridine-2-carboxylic acid
CAS No.: 100047-36-7
Chemical Name: 4-Aminopyridine-2-carboxylic acid
Synonyms: 4-AMINOPICOLINIC ACID;IFLAB-BB F1926-0040;4-Aminopicolinic acid - [A12444];4-AMINOPYRIDINE-2-CARBOXYLIC ACID;2-Pyridinecarboxylic acid, 4-amino-;4-Aminopyridine-2-carboxylic acid 97%;4-Aminopyridine-2-carboxylic acid ,97%;2-Pyridinecarboxylicacid,4-amino-(9CI);4-Aminopyridine-2-carboxylic acid USP/EP/BP;100047-36-4-aminopyridine-2-carboxylic Acid7
CBNumber: CB5401109
Molecular Formula: C6H6N2O2
Formula Weight: 138.12
MOL File: 100047-36-7.mol

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4-Aminopyridine-2-carboxylic acid Property

Melting point:: 265 °C
Boiling point:: 446.3±30.0 °C(Predicted)
Density: 1.417±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Acetone, Ethanol, Methanol
form: Solid
pka: 1.37±0.50(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C6H6N2O2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H2,7,8)(H,9,10)
InChIKey: JRZBTJVSAANBEV-UHFFFAOYSA-N
SMILES: C1(C(O)=O)=NC=CC(N)=C1
CAS DataBase Reference: 100047-36-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 50A-24/25-36/37/39
RIDADR: 2761
Hazard Note: Irritant
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS007808
Product name: 4-aminopyridine-2-carboxylic acid
Purity: Aldrich
Packaging: 250mg
Price: $73.1
Updated: 2025/07/31

TRC

Product number: A627805
Product name: 4-AminopicolinicAcid
Packaging: 5g
Price: $580
Updated: 2021/12/16

TRC

Product number: A627805
Product name: 4-AminopicolinicAcid
Packaging: 25g
Price: $2475
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK142952
Product name: 4-aminopyridine-2-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $560
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 6759
Product name: 4-AminopicolinicAcid
Packaging: 50mg
Price: $1760
Updated: 2021/12/16

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4-Aminopyridine-2-carboxylic acid Chemical Properties,Usage,Production

Description

4-Aminopyridine-2-carboxylic acid is an organic synthetic reagent used in the preparation of 4-amino-6-(heterocyclic)pyridine carboxylic acid esters, 4-amino-2,6-dimethylnicotinic acid esters and amides.

Chemical Properties

White solid

Uses

4-Aminopyridine-2-carboxylic acid can be a useful synthetic intermediate

Synthesis

1918-02-1

100047-36-7

General procedure for the synthesis of 4-aminopyridine-2-carboxylic acid from 4-amino-3,5,6-trichloropyridine-2-carboxylic acid: a thick suspension formed by Picloram (8 g, 33 mmol) and 10% Pd/C (1.2 g) in a 10% aqueous LiOH solution (44 mL) was purged twice with hydrogen, and then under a hydrogen atmosphere (45 PSI) at 40°C for 4 hours with stirring. Subsequently, the mixture was heated to 70°C and maintained for 12 hours. Upon completion of the reaction, the cooled suspension was filtered through diatomaceous earth. The filtrate was acidified to pH=3 in concentrated HCl (~3.5 mL), at which point a precipitate was generated. The solid product was collected by filtration and dried overnight under high vacuum to give the final 4-aminopyridine-2-carboxylic acid as a beige solid (4.6 g, 99% yield).LCMS analysis showed m/z 139.1 (M + H)+ with a retention time of 0.21 minutes.

References

[1] Patent: WO2012/3576, 2012, A1. Location in patent: Page/Page column 96

4-Aminopyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethanol Acetic anhydride Acetone Triethylamine Diethyl ether Hydrochloric acid 4-Nitro-2-picoline N-oxide Potassium permanganate Iron 4-Amino-2-picoline

Preparation Products

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4-Aminopyridine-2-carboxylic acid Suppliers

Canada 3 China 141 Europe 1 France 2 Germany 6 India 6 Switzerland 2 United Kingdom 12 United States 41 Global 214

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J & K SCIENTIFIC LTD.

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Shanghai Longsheng chemical Co.,Ltd.

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View Lastest Price from 4-Aminopyridine-2-carboxylic acid manufacturers

RongNa Biotechnology Co.,Ltd

Product: 4-Aminopyridine-2-carboxylic acid 100047-36-7
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-27

Career Henan Chemical Co

Product: 4-Aminopyridine-2-carboxylic acid 100047-36-7
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%;99%
Supply Ability: 1kg； 5kg；10kg；25kg
Release date: 2020-01-07

100047-36-7, 4-Aminopyridine-2-carboxylic acidRelated Search:

3-Aminopyridine 4-Aminopyridine Urethane Chromium picolinate POLYURETHANE 2-Aminopyridine 4-Aminobenzoic acid Anthranilic acid 4-NITROPICOLINIC ACID PICLORAM METHYL ESTER Picloram Methyl 4-aminopyridine-2-carboxylate Minocromil 3-Aminoisonicotinic acid hydrate (1:1) 3-AMINOPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER 3-Aminopyridine-2-carboxylic acid ethyl ester 2-Aminopyridine-4-carboxylic acid ,97%,2-AMINOPYRIDINE-4-CARBOXYLIC ACID 4-AMINO-3-CHLORO-PYRIDINE-2-CARBOXYLIC ACID

4-AMINOPYRIDINE-2-CARBOXYLIC ACID

4-AMINOPICOLINIC ACID

2-Pyridinecarboxylicacid,4-amino-(9CI)

IFLAB-BB F1926-0040

2-Pyridinecarboxylic acid, 4-amino-

4-Aminopyridine-2-carboxylic acid 97%

4-Aminopyridine-2-carboxylic acid ,97%

4-Aminopicolinic acid, 4-Amino-2-carboxypyridine

4-Aminopyridine-2-carboxylic acid USP/EP/BP

100047-36-4-aminopyridine-2-carboxylic Acid7

4-<WBR>aminopyridine-<WBR>2-<WBR>carboxylic acid

4-Aminopicolinic acid - [A12444]

100047-36-7

Aromatics

Carboxylic Acids

API intermediates

Aromatics Compounds

AMINOACID

Pyridines

PYRIDINE

CARBOXYLICACID