N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE

Product Name: N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
CAS No.: 149649-22-9
Chemical Name: N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
Synonyms: NAFADOTRIDE;N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE;2-Naphthalenecarboxamide, N-[(1-butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-
CBNumber: CB5402878
Molecular Formula: C22H27N3O2
Formula Weight: 365.47
MOL File: 149649-22-9.mol

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N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE Property

Boiling point:: 556.6±40.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Desiccate at RT
pka: 12.84±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: N210005
Product name: Nafadotride
Packaging: 5mg
Price: $795
Updated: 2021/12/16

TRC

Product number: N210005
Product name: Nafadotride
Packaging: 10mg
Price: $1400
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000616
Product name: NAFADOTRIDE
Purity: 95.00%
Packaging: 100MG
Price: $3571.55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000616
Product name: NAFADOTRIDE
Purity: 95.00%
Packaging: 250MG
Price: $9028.93
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000616
Product name: NAFADOTRIDE
Purity: 95.00%
Packaging: 10MG
Price: $1024.78
Updated: 2021/12/16

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N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE Chemical Properties,Usage,Production

Uses

Nafadotride is a highly potent and competitive dopamine D3 receptor (D3R) antagonist.

Definition

ChEBI: A naphthalenecarboxamide resulting from the formal condensation of the carboxylic acid group of 4-cyano-1-methoxynaphthalene-2-carboxylic acid with the primary amino group of 1-(1-butylpyrrolidin-2-yl]methanamine. It is a highly potent, competitive, prefer ntial dopamine D3 receptor antagonist, centrally active upon systemic administration.

Biological Activity

Highly potent, competitive, preferential dopamine D 3 receptor antagonist. K i values are 0.52, 5, and 269 nM for human cloned D 3 , D 2 and D 4 receptors respectively. Centrally active upon systemic administration.

N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE Suppliers

China 18 Germany 1 India 1 Japan 1 United Kingdom 2 United States 9 Global 32

3B Pharmachem (Wuhan) International Co.,Ltd.

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149649-22-9, N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDERelated Search:

3-CYANOBENZYLAMINE 3-Cyanobenzaldehyde 3-(methylaminomethyl)benzonitrile 3-CYANO-BENZAMIDE 3-Formyl-4-hydroxybenzonitrile N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE 1-Cyanonaphthalene (-)-N[(N-BUTYL-2-PYRROLIDINYL)METHYL]-1-METHOXY-4-CYANONAPHTHALENE-2-CARBOXAMIDE TARTRATE 4-METHOXY-1-NAPHTHONITRILE

NAFADOTRIDE

N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE

2-Naphthalenecarboxamide, N-[(1-butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-

149649-22-9

C22H27N3O2