methyl 3-(4-methylphenylsulfonamido)benzoate

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methyl 3-(4-methylphenylsulfonamido)benzoate

Product Name: methyl 3-(4-methylphenylsulfonamido)benzoate
CAS No.: 173436-66-3
Chemical Name: methyl 3-(4-methylphenylsulfonamido)benzoate
Synonyms: MSAB;GSK549;MSAB >=95% (HPLC);methyl 3-(4-methylphenylsulfonamido)benzoate;Methyl 3-(4-Methylbenzenesulfonamido)benzoate;Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester;anti-tumor,Wnt,inhibit,MSAB,degradation,β-catenin,Inhibitor,Beta catenin,cancer
CBNumber: CB54050666
Molecular Formula: C15H15NO4S
Formula Weight: 305.35
MOL File: 173436-66-3.mol

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methyl 3-(4-methylphenylsulfonamido)benzoate Property

Melting point:: 152-154 °C
Boiling point:: 456.5±55.0 °C(Predicted)
Density: 1.312±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly)
form: powder
pka: 7.88±0.10(Predicted)
color: off-white to purple

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1726
Product name: MSAB
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1726
Product name: MSAB
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $464
Updated: 2024/03/01

ChemScene

Product number: CS-0078728
Product name: MSAB
Purity: 99.77%
Packaging: 100mg
Price: $680
Updated: 2021/12/16

ChemScene

Product number: CS-0078728
Product name: MSAB
Purity: 99.77%
Packaging: 5mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0078728
Product name: MSAB
Purity: 99.77%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

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methyl 3-(4-methylphenylsulfonamido)benzoate Chemical Properties,Usage,Production

Biochem/physiol Actions

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

methyl 3-(4-methylphenylsulfonamido)benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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173436-66-3, methyl 3-(4-methylphenylsulfonamido)benzoateRelated Search:

methyl 3-(4-methylphenylsulfonamido)benzoate

MSAB

Methyl 3-(4-Methylbenzenesulfonamido)benzoate

GSK549

Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester

MSAB >=95% (HPLC)

anti-tumor,Wnt,inhibit,MSAB,degradation,β-catenin,Inhibitor,Beta catenin,cancer

173436-66-3