ChemicalBook > CAS DataBase List > methyl 3-(4-methylphenylsulfonamido)benzoate

methyl 3-(4-methylphenylsulfonamido)benzoate

Product Name: methyl 3-(4-methylphenylsulfonamido)benzoate
CAS No.: 173436-66-3
Chemical Name: methyl 3-(4-methylphenylsulfonamido)benzoate
Synonyms: MSAB;GSK549;MSAB >=95% (HPLC);MSAB, 10 mM in DMSO;3-Methoxycarbonylphenyl toluenesulfonamide;methyl 3-(4-methylphenylsulfonamido)benzoate;Methyl 3-(4-Methylbenzenesulfonamido)benzoate;Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate;Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester;anti-tumor,Wnt,inhibit,MSAB,degradation,β-catenin,Inhibitor,Beta catenin,cancer
CBNumber: CB54050666
Molecular Formula: C15H15NO4S
Formula Weight: 305.35
MOL File: 173436-66-3.mol

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methyl 3-(4-methylphenylsulfonamido)benzoate Property

Melting point:: 152-154 °C
Boiling point:: 456.5±55.0 °C(Predicted)
Density: 1.312±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly)
form: powder
pka: 7.88±0.10(Predicted)
color: off-white to purple

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1726
Product name: MSAB
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $99.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1726
Product name: MSAB
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $405
Updated: 2025/07/31

ChemScene

Product number: CS-0078728
Product name: MSAB
Purity: 99.77%
Packaging: 25mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0078728
Product name: MSAB
Purity: 99.77%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0078728
Product name: MSAB
Purity: 99.77%
Packaging: 100mg
Price: $680
Updated: 2021/12/16

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methyl 3-(4-methylphenylsulfonamido)benzoate Chemical Properties,Usage,Production

Uses

MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells[1].

Biochem/physiol Actions

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

in vivo

MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model^[1].
MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice^[1].

Animal Model:	Athymic nude mice (5-6 weeks) are injected HCT116, HT115, H23, or H460 cells^[1]
Dosage:	10, 20 mg/kg
Administration:	I.p. daily for 2 weeks
Result:	Reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors.

References

[1] Hwang SY, et, al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Rep. 2016 Jun 28;16(1):28-36. DOI:10.1016/j.celrep.2016.05.071

methyl 3-(4-methylphenylsulfonamido)benzoate Preparation Products And Raw materials

Raw materials

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173436-66-3, methyl 3-(4-methylphenylsulfonamido)benzoateRelated Search:

methyl 3-(4-methylphenylsulfonamido)benzoate

MSAB

Methyl 3-(4-Methylbenzenesulfonamido)benzoate

GSK549

Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester

MSAB >=95% (HPLC)

anti-tumor,Wnt,inhibit,MSAB,degradation,β-catenin,Inhibitor,Beta catenin,cancer

3-Methoxycarbonylphenyl toluenesulfonamide

MSAB, 10 mM in DMSO

Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate

173436-66-3