methyl 3-(4-methylphenylsulfonamido)benzoate
- Product Name
- methyl 3-(4-methylphenylsulfonamido)benzoate
- CAS No.
- 173436-66-3
- Chemical Name
- methyl 3-(4-methylphenylsulfonamido)benzoate
- Synonyms
- MSAB;GSK549;MSAB >=95% (HPLC);MSAB, 10 mM in DMSO;3-Methoxycarbonylphenyl toluenesulfonamide;methyl 3-(4-methylphenylsulfonamido)benzoate;Methyl 3-(4-Methylbenzenesulfonamido)benzoate;Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate;Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester;anti-tumor,Wnt,inhibit,MSAB,degradation,β-catenin,Inhibitor,Beta catenin,cancer
- CBNumber
- CB54050666
- Molecular Formula
- C15H15NO4S
- Formula Weight
- 305.35
- MOL File
- 173436-66-3.mol
methyl 3-(4-methylphenylsulfonamido)benzoate Property
- Melting point:
- 152-154 °C
- Boiling point:
- 456.5±55.0 °C(Predicted)
- Density
- 1.312±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- powder
- pka
- 7.88±0.10(Predicted)
- color
- off-white to purple
N-Bromosuccinimide Price
- Product number
- SML1726
- Product name
- MSAB
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $99.5
- Updated
- 2025/07/31
- Product number
- SML1726
- Product name
- MSAB
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $405
- Updated
- 2025/07/31
- Product number
- CS-0078728
- Product name
- MSAB
- Purity
- 99.77%
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0078728
- Product name
- MSAB
- Purity
- 99.77%
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- CS-0078728
- Product name
- MSAB
- Purity
- 99.77%
- Packaging
- 100mg
- Price
- $680
- Updated
- 2021/12/16
methyl 3-(4-methylphenylsulfonamido)benzoate Chemical Properties,Usage,Production
Uses
MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells[1].
Biochem/physiol Actions
A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.
in vivo
MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model[1].
MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice[1].
| Animal Model: | Athymic nude mice (5-6 weeks) are injected HCT116, HT115, H23, or H460 cells[1] |
| Dosage: | 10, 20 mg/kg |
| Administration: | I.p. daily for 2 weeks |
| Result: | Reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors. |
References
[1] Hwang SY, et, al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Rep. 2016 Jun 28;16(1):28-36. DOI:10.1016/j.celrep.2016.05.071
methyl 3-(4-methylphenylsulfonamido)benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 3-(4-methylphenylsulfonamido)benzoate Suppliers
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