ChemicalBook > CAS DataBase List > 2,3-Dichloroquinoxaline

2,3-Dichloroquinoxaline

Product Name
2,3-Dichloroquinoxaline
CAS No.
2213-63-0
Chemical Name
2,3-Dichloroquinoxaline
Synonyms
cp42103-4;NSC 33437;oroquinoxaL;AKOS BBS-00006726;TIMTEC-BB SBB003555;SALOR-INT L497169-1EA;3-Dichloroquinoxaline;2,3-DICHLOROQUINOXALINE;2,3-dichloro-quinoxalin;2,3-Dichlcroquinoxaline
CBNumber
CB5414800
Molecular Formula
C8H4Cl2N2
Formula Weight
199.04
MOL File
2213-63-0.mol
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2,3-Dichloroquinoxaline Property

Melting point:
152-154 °C (lit.)
Boiling point:
325.69°C (rough estimate)
Density 
1.4994 (rough estimate)
refractive index 
1.6400 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Insoluble in water
solubility 
soluble in Chloroform
form 
Needles
pka
-4.78±0.48(Predicted)
color 
Off-white to light brown
BRN 
126076
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
SPSSDDOTEZKOOV-UHFFFAOYSA-N
CAS DataBase Reference
2213-63-0(CAS DataBase Reference)
EPA Substance Registry System
2,3-Dichloroquinoxaline (2213-63-0)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37/39-45-37/39-28A
RIDADR 
2811
WGK Germany 
3
RTECS 
VD1720000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339900
Toxicity
mouse,LD50,intravenous,5600ug/kg (5.6mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03256,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
144525
Product name
2,3-Dichloroquinoxaline
Purity
96%
Packaging
10g
Price
$59.9
Updated
2024/03/01
Sigma-Aldrich
Product number
144525
Product name
2,3-Dichloroquinoxaline
Purity
96%
Packaging
50g
Price
$274
Updated
2023/06/20
TCI Chemical
Product number
D2622
Product name
2,3-Dichloroquinoxaline
Purity
>98.0%(GC)
Packaging
5g
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
D2622
Product name
2,3-Dichloroquinoxaline
Purity
>98.0%(GC)
Packaging
25g
Price
$145
Updated
2024/03/01
Alfa Aesar
Product number
A11734
Product name
2,3-Dichloroquinoxaline, 98%
Packaging
25g
Price
$142.65
Updated
2024/03/01
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2,3-Dichloroquinoxaline Chemical Properties,Usage,Production

Description

2,3-Dichloroquinoxaline (DCQX) can be used as a substrate for nucleophilic aromatic substitution (SNAr) reactions and is a versatile building block for the synthesis of many quinoxaline derivatives. 2,3-Dichloroquinoxaline reacts with 6-aminothiouracil in ethanol/TEA to form 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one. It reacts with cholest-5-en-3-one semicarbazone/thiosemicarbazone to form steriodal cholest-5-en-3-oxazolo and thiazoloquinoxaline.

Chemical Properties

solid

Uses

2,3-Dichloroquinoxaline is a dichlorinated quinoxaline derivative with antimicrobial activity. 2,3-Dichloroquinoxaline is used in the preparation of quinoxaline derivatives of cancer chemopreventive a ctivity.

Uses

2,3-Dichloroquinoxaline was used in the synthesis of mono and 2,3-disubstituted quinoxalines. It was used in solid phase synthesis of HPLC chiral stationary phase containing the N,N′-dialkyl-2,3-diaminoquinoxaline group as a linking structure.

Preparation

To a stirred solution of quinoxaline-2,3(1H,4H)-dione (5.00 g, 1.0 equiv.), POCl3 was added (20 ml) and refluxed at 100 °C for 3h. After completion of the reaction, as indicated by TLC, the reaction mass was distilled under vaccum and quenched with ice cold water. Off white semi solid was formed and is filtered through buchner funnel under vaccum to yield the 2,3-dichloroquinoxaline in excellent yield.

Appearance: off white solid; Yield: 92% (5.64g); ESI-MS: (m/z) calcd. for C8H4Cl2N2: 197.98, found: 199.10 [M+H]+.

General Description

Gray solid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

2,3-Dichloroquinoxaline is probably combustible.

Purification Methods

Recrystallise it from *C6H6 and dry it in a vacuum [Cheeseman J Chem Soc 1804 1955, Beilstein 23/7 V 144].

2,3-Dichloroquinoxaline Preparation Products And Raw materials

Raw materials

Preparation Products

2-CHLORO-3-(4-MORPHOLINYL)QUINOXALINE 2 CHLORO-3-AMINO QUINOXALINE 2-CHLORO-3-(3,5-DIMETHYL-PYRAZOL-1-YL)-QUINOXALINE
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2,3-Dichloroquinoxaline Suppliers

Americas 1 Belgium 3 Canada 2 China 267 Czech Republic 2 Europe 1 France 1 Germany 8 Hungary 1 India 22 Japan 4 South Korea 1 Switzerland 2 The Netherlands 3 Ukraine 2 United Kingdom 13 United States 47 Global 380
Wuhan Vanzpharm Inc.
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View Lastest Price from 2,3-Dichloroquinoxaline manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2,3-Dichloroquinoxaline 2213-63-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
2,3-Dichloroquinoxaline 2213-63-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.00%
Supply Ability
100tons
Release date
2023-09-26
Hebei Chuanghai Biotechnology Co,.LTD
Product
2, 3-Dichloroquinoxaline 2213-63-0
Price
US $10.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2024-08-13

2213-63-0, 2,3-DichloroquinoxalineRelated Search:

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