Clidinium bromide
- Product Name
- Clidinium bromide
- CAS No.
- 3485-62-9
- Chemical Name
- Clidinium bromide
- Synonyms
- Clidinium;QUARZAN;Ro-3773;AV54315;AV 54315;AV-54315;RO-2-3773;quarzanbromide;CLIDINIUM BROMIDE;Clidinium Brimide
- CBNumber
- CB5419496
- Molecular Formula
- C22H26BrNO3
- Formula Weight
- 432.35
- MOL File
- 3485-62-9.mol
Clidinium bromide Property
- Melting point:
- 240-241°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
- color
- White to Off-White
- CAS DataBase Reference
- 3485-62-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C0414
- Product name
- Clidinium bromide
- Purity
- analytical standard
- Packaging
- 1g
- Price
- $98.1
- Updated
- 2024/03/01
- Product number
- 1135000
- Product name
- Clidinium bromide
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 21428
- Product name
- Clidinium (bromide)
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 21428
- Product name
- Clidinium (bromide)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $73
- Updated
- 2024/03/01
- Product number
- C576250
- Product name
- Clidinium bromide
- Packaging
- 50g
- Price
- $1580
- Updated
- 2021/12/16
Clidinium bromide Chemical Properties,Usage,Production
Description
Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes). Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice. This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.
Chemical Properties
White Crystalline Solid
Originator
Librax,Roche,US,1961
Uses
An anticholinergic. Used as an antispasmodic.
Uses
Clidinium inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used for treating stomach ulcers.
Definition
ChEBI: The bromide salt of clinidium. It is used for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Manufacturing Process
5.12 g of 1-azabicyclo[2.2.2]-3-octanol were refluxed with a suspension of
0.92 g of finely divided sodium in 50 cc of toluene, until most of the sodium
had reacted (about 4 hours). The thus obtained suspension of the white
amorphous alcoholate was cooled with ice, and reacted with 10.16 g of
diphenylchloroacetyl chloride, which was added in form of a solution in
approximately 40 cc of toluene. The mixture was stirred for 1 hour at room
temperature. Small amounts of unreacted sodium were destroyed with
isopropanol, and 120 cc of 1 N hydrochloric acid were then added, The
mixture was refluxed for 1/2 hour, in order to convert the first formed
product, diphenylchloroacetic acid ester of 1-azabicyclo[2.2.2]-3-octanol, into
the corresponding benzilic acid ester.
The toluene phase was separated and discarded. The aqueous phase, together
with a precipitated water- and toluene-insoluble oil, was made alkaline and
extracted repeatedly with chloroform. The chloroform solution was
concentrated in vacuo. The residue was recrystallized from a mixture of
acetone and ether (alternatively, from chloroform and ether), and formed
needles melting at 164° to 165°C. It was identified as 3-benziloyloxy-1-
azabicyclo[2.2.2]octane.
3-Benziloyloxy-1-azabicyclo[2.2.2]octane methobromide was prepared by
adding 20 cc of a 30% solution of methyl bromide in ether to a solution of 2.5
g of 3-benziloyloxy-1-azabicyclo[2.2.2]octane in 20 cc of chloroform. After
standing for 3 hours at room temperature and 15 hours at +5°C, a crystalline
precipitate had formed. This was filtered off and recrystallized from a mixture
of methanol, acetone, and ether; prisms melting at 240° to 241°C.
brand name
Quarzan (Roche).
Therapeutic Function
Anticholinergic, Antiulcer
General Description
Clidinium bromide, 3-hydroxy-1-methylquinuclidinium bromide benzilate (Quarzan),is a white or nearly white, almost odorless, crystalline powderthat is optically inactive. It is soluble in water and alcohol butonly very slightly soluble in ether and benzene.
Clinical Use
This anticholinergic agent is marketed alone and in combinationwith the minor tranquilizer chlordiazepoxide (Librium)in a product known as Librax. The rationale of the combinationfor the treatment of GI complaints is the use of an anxiety-reducing agent together with an anticholinergic agent,based on the recognized contribution of anxiety to the developmentof the diseased condition. It is suggested for pepticulcer, hyperchlorhydria, ulcerative or spastic colon, anxietystates with GI manifestations, nervous stomach, irritable orspastic colon, and others. Clidinium bromide is contraindicatedin glaucoma and other conditions that may be aggravatedby the parasympatholytic action, such as prostatic hypertrophyin elderly men, which could lead to urinary retention.
Synthesis
Clidinium, 3-benzyloyloxy-1-methylcynuclidinium bromide (14.1.19), is synthesized by reacting 3-hydroxycynuclidine (14.1.17) with the of benzilic acid chloride producing the ester (14.1.18), which if further alkylated at the nitrogen atom by methylbromide, giving clidinium (14.1.19) [16].
Clidinium bromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Clidinium bromide manufacturers
- Product
- Clidinium bromide 3485-62-9
- Price
- US $132.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 10-100kg
- Release date
- 2021-06-04
- Product
- Clidinium bromide 3485-62-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Clidinium bromide 3485-62-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08