Clidinium bromide

ChemicalBook > CAS DataBase List > Clidinium bromide

Product Name: Clidinium bromide
CAS No.: 3485-62-9
Chemical Name: Clidinium bromide
Synonyms: Clidinium;QUARZAN;Ro-3773;AV54315;AV 54315;AV-54315;RO-2-3773;quarzanbromide;CLIDINIUM BROMIDE;Clidinium Brimide
CBNumber: CB5419496
Molecular Formula: C22H26BrNO3
Formula Weight: 432.35
MOL File: 3485-62-9.mol

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Clidinium bromide Property

Melting point:: 240-241°C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form: Solid
color: White to Off-White
CAS DataBase Reference: 3485-62-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
RIDADR: 3249
WGK Germany: 3
RTECS: VD6125000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C0414
Product name: Clidinium bromide
Purity: analytical standard
Packaging: 1g
Price: $98.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1135000
Product name: Clidinium bromide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 21428
Product name: Clidinium (bromide)
Purity: ≥98%
Packaging: 500mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 21428
Product name: Clidinium (bromide)
Purity: ≥98%
Packaging: 1g
Price: $73
Updated: 2024/03/01

TRC

Product number: C576250
Product name: Clidinium bromide
Packaging: 50g
Price: $1580
Updated: 2021/12/16

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Clidinium bromide Chemical Properties,Usage,Production

Description

Clidinium is a gastrointestinal muscarinic receptor antagonist (K_i = 3 nM against [³H]quinuclidinyl benzilate binding in rat colonic enterocytes). Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice. This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.

Chemical Properties

White Crystalline Solid

Originator

Librax,Roche,US,1961

Uses

An anticholinergic. Used as an antispasmodic.

Uses

Clidinium inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used for treating stomach ulcers.

Definition

ChEBI: The bromide salt of clinidium. It is used for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.

Manufacturing Process

5.12 g of 1-azabicyclo[2.2.2]-3-octanol were refluxed with a suspension of 0.92 g of finely divided sodium in 50 cc of toluene, until most of the sodium had reacted (about 4 hours). The thus obtained suspension of the white amorphous alcoholate was cooled with ice, and reacted with 10.16 g of diphenylchloroacetyl chloride, which was added in form of a solution in approximately 40 cc of toluene. The mixture was stirred for 1 hour at room temperature. Small amounts of unreacted sodium were destroyed with isopropanol, and 120 cc of 1 N hydrochloric acid were then added, The mixture was refluxed for 1/2 hour, in order to convert the first formed product, diphenylchloroacetic acid ester of 1-azabicyclo[2.2.2]-3-octanol, into the corresponding benzilic acid ester.
The toluene phase was separated and discarded. The aqueous phase, together with a precipitated water- and toluene-insoluble oil, was made alkaline and extracted repeatedly with chloroform. The chloroform solution was concentrated in vacuo. The residue was recrystallized from a mixture of acetone and ether (alternatively, from chloroform and ether), and formed needles melting at 164° to 165°C. It was identified as 3-benziloyloxy-1- azabicyclo[2.2.2]octane.
3-Benziloyloxy-1-azabicyclo[2.2.2]octane methobromide was prepared by adding 20 cc of a 30% solution of methyl bromide in ether to a solution of 2.5 g of 3-benziloyloxy-1-azabicyclo[2.2.2]octane in 20 cc of chloroform. After standing for 3 hours at room temperature and 15 hours at +5°C, a crystalline precipitate had formed. This was filtered off and recrystallized from a mixture of methanol, acetone, and ether; prisms melting at 240° to 241°C.

brand name

Quarzan (Roche).

Therapeutic Function

Anticholinergic, Antiulcer

General Description

Clidinium bromide, 3-hydroxy-1-methylquinuclidinium bromide benzilate (Quarzan),is a white or nearly white, almost odorless, crystalline powderthat is optically inactive. It is soluble in water and alcohol butonly very slightly soluble in ether and benzene.

Clinical Use

This anticholinergic agent is marketed alone and in combinationwith the minor tranquilizer chlordiazepoxide (Librium)in a product known as Librax. The rationale of the combinationfor the treatment of GI complaints is the use of an anxiety-reducing agent together with an anticholinergic agent,based on the recognized contribution of anxiety to the developmentof the diseased condition. It is suggested for pepticulcer, hyperchlorhydria, ulcerative or spastic colon, anxietystates with GI manifestations, nervous stomach, irritable orspastic colon, and others. Clidinium bromide is contraindicatedin glaucoma and other conditions that may be aggravatedby the parasympatholytic action, such as prostatic hypertrophyin elderly men, which could lead to urinary retention.

Synthesis

Clidinium, 3-benzyloyloxy-1-methylcynuclidinium bromide (14.1.19), is synthesized by reacting 3-hydroxycynuclidine (14.1.17) with the of benzilic acid chloride producing the ester (14.1.18), which if further alkylated at the nitrogen atom by methylbromide, giving clidinium (14.1.19) [16].

Clidinium bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Clidinium bromide manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: Clidinium bromide 3485-62-9
Price: US $132.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 10-100kg
Release date: 2021-06-04

Shaanxi Dideu Medichem Co. Ltd

Product: Clidinium Bromide 3485-62-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Clidinium bromide 3485-62-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

3485-62-9, Clidinium bromideRelated Search:

Pinaverium bromide Tiotropium bromide Bisacodyl Ethidium bromide Thiophanate-methyl tert-Butylchlorodiphenylsilane Rocuronium bromide Bensulfuron methyl Benzyldodecyldimethylammonium bromide Diphenylsilane Methylparaben Chlorodiphenylphosphine Allyl bromide Diphenylphosphine Benzyl bromide Pipecuronium bromide Ipratropium bromide monohydrate CHLOROPHOSPHONAZO III

CLIDINIUM BROMIDE

3-[(HYDROXYPHENYLACETYL)OXY]-1-METHYL-1-AZONIABICYCLO[2,2,2]OCTANE BROMIDE

3-HYDROXY-1-METHYLQUINUCLIDINIUM BROMIDE BENZILATE

QUARZAN

RO-2-3773

quinuclidinolmethylbromide,benzilate

3-[(Hydroxyphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2,2,2]octane Bromide, Ro-2-3773, Quarzan

Clidinium

(1-Methyl-1-azoniabicyclo[2.2.2]octan-8-yl) 2-hydroxy-2,2-diphenylacetate bromide

1-Azoniabicyclo[2.2.2]octane, 3-[(hydroxydiphenylacetyl)oxy]-1-methyl-, bromide

3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide

Ro-3773

3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane

Clidinium Brimide

Clidinium Bromide (500 mg)

Clidinium Bromide (2 g)

3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-Methyl-1-azabicyclo[2.2.2]octan-1-iuM broMide

Clidinium iodide D3

1-methyl-3-benzil-oxyloxy-quinuclidiniumbromide

3-((hydroxydiphenylacetyl)oxy)-1-methyl-1-azoniabicyclo(2.2.2)octanbromi

3-(2,2-diphenyl-2-hydroxyethanoyloxy)-quinuclidiniumbromide

3-(benziloyloxy)-1-methylquinuclidiniumbromide

benzilicacid,esterwith3-hydroxy-1-methylquinuclidinium

quarzanbromide

quinuclidinium,3-hydroxy-1-methyl-,bromide,benzilate

2-hydroxy-2,2-diphenylacetic acid (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) ester bromide

3-(2-Hydroxy-2,2-diphenylacetoxy)-1-methylquinuclidin-1-ium bromide

Clidinium BromideQ: What is Clidinium Bromide Q: What is the CAS Number of Clidinium Bromide Q: What is the storage condition of Clidinium Bromide Q: What are the applications of Clidinium Bromide

Clidinium-D5 bromideQ: What is Clidinium-D5 bromide Q: What is the CAS Number of Clidinium-D5 bromide

Clidinium Bromide (1135000)

AV 54315

AV54315

AV-54315

3485-62-9

C22H26NO3Br

C22H26BO3Rn

C22H26BrNO3

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