Bisacodyl
- Product Name
- Bisacodyl
- CAS No.
- 603-50-9
- Chemical Name
- Bisacodyl
- Synonyms
- bisacodil;dulcolax;4,4’-(2-pyridylmethylene)-diphenolacetate;(Pyridin-2-ylMethylene)bis(4,1-phenylene) diacetate;laco;Bicol;LA96A;neolax;ivilax;Laxans
- CBNumber
- CB2233693
- Molecular Formula
- C22H19NO4
- Formula Weight
- 361.39
- MOL File
- 603-50-9.mol
Bisacodyl Property
- Melting point:
- 138°C
- Boiling point:
- 493.21°C (rough estimate)
- Density
- 1.2545 (rough estimate)
- refractive index
- 1.5614 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids.
- pka
- 4.69±0.10(Predicted)
- color
- White to Off-White
- Water Solubility
- Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
- λmax
- 220nm(MeOH)(lit.)
- Merck
- 14,1242
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- KHOITXIGCFIULA-UHFFFAOYSA-N
- LogP
- 3.453 (est)
- CAS DataBase Reference
- 603-50-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Bisacodyl(603-50-9)
- EPA Substance Registry System
- Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) (603-50-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- SM8750000
- TSCA
- Yes
- HS Code
- 2933399090
- Hazardous Substances Data
- 603-50-9(Hazardous Substances Data)
- Toxicity
- LD50 orally in rats: >3 g/kg (Schmidt)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR2794
- Product name
- Bisacodyl
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 250MG
- Price
- $158
- Updated
- 2024/03/01
- Product number
- BP047
- Product name
- Bisacodyl
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $266
- Updated
- 2024/03/01
- Product number
- B1390
- Product name
- Bisacodyl
- Purity
- analytical standard, for drug analysis
- Packaging
- 10g
- Price
- $100
- Updated
- 2024/03/01
- Product number
- B1140000
- Product name
- Bisacodyl
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- b1140000
- Price
- $88
- Updated
- 2024/03/01
- Product number
- B5066
- Product name
- Bisacodyl
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $76
- Updated
- 2024/03/01
Bisacodyl Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Originator
Dulcolax,Boehringer Ingelheim,US,1958
Uses
Cathartic.
Uses
Stimulant laxative.
Uses
Bisacodyl is used in the inhibition of (Na+K)ATPase, the increase of mucosal PGE2, and the activation of adenyl cyclase in rat intestine studies. It is used as a laxative drug. It is typically prescribed for relief of constipation.
Definition
ChEBI: Bisacodyl is a diarylmethane.
Manufacturing Process
Preparation of (4,4'-Dihydroxy-Diphenyl)-(Pyridyl-2)-Methane
70.0 grams of α-pyridine aldehyde are fed portionwise with stirring and
cooling to a mixture of 200 grams of phenol and 100 cc of concentrated
sulfuric acid. The reaction mixture is allowed to stand for a while with
repeated stirring, whereby it becomes syrupy, neutralized with sodium
carbonate, dissolved in methanol and filtered. The filtrate is introduced into a
large quantity of water and the resulting precipitate is recrystallized from a
methanol/water mixture. Colorless crystals are obtained of MP 254°C. When
using zinc chloride or tin tetrachloride and warming to a temperature of about
50°C, a corresponding result is obtained.
Preparation of Bisacodyl: 5 grams of (4,4'-dihydroxy-diphenyl)-(pyridyl-2)-
methane are heated with 5 grams of anhydrous sodium acetate and 20 cc of
acetic anhydride for three hours over a boiling water bath. The cooled reaction
mixture is poured into water, whereby after a while a colorless substance
precipitates, which is filtered off with suction, washed with water and
recrystallized from aqueous ethanol. Colorless bright crystals, MP 138°C are
obtained.
brand name
Correctol Tablets, Caplets (Schering-Plough HealthCare); Dulcolax (Boehringer Ingelheim); Evac-Q-Tabs (Savage); Feen-a- Mint Tablets (Schering-Plough HealthCare); Modane (Savage); SK-Bisacodyl (SmithKline Beecham); Theralax (SmithKline Beecham).
Therapeutic Function
Laxative
Clinical Use
Laxative
Veterinary Drugs and Treatments
Bisacodyl oral and rectal products are used as stimulant cathartics in dogs and cats.
Metabolism
Bisacodyl is rapidly hydrolysed to the active principle bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), mainly by esterases of the enteric mucosa. After oral and rectal administration, only small amounts of the drug are absorbed and are almost completely conjugated in the intestinal wall and the liver to form the inactive BHPM glucuronide. Following the administration of bisacodyl coated tablets, an average of 51.8% of the dose was recovered in the faeces as free BHPM and an average of 10.5% of the dose was recovered in the urine as BHPM glucuronide. Following the administration as a suppository, an average of 3.1% of the dose was recoveredas BHPM glucuronide in the urine. Stool contained large amounts of BHPM (90% of the total excretion) in addition to small amounts of unchanged bisacodyl
Bisacodyl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Bisacodyl manufacturers
- Product
- Bisacodyl 603-50-9
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000
- Release date
- 2024-03-22
- Product
- Bisacodyl 603-50-9
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-09-16
- Product
- Bisacodyl 603-50-9
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-10-24