Bisacodyl

ChemicalBook > CAS DataBase List > Bisacodyl

Product Name: Bisacodyl
CAS No.: 603-50-9
Chemical Name: Bisacodyl
Synonyms: bisacodil;dulcolax;4,4’-(2-pyridylmethylene)-diphenolacetate;(Pyridin-2-ylMethylene)bis(4,1-phenylene) diacetate;laco;Bicol;LA96A;neolax;ivilax;Laxans
CBNumber: CB2233693
Molecular Formula: C22H19NO4
Formula Weight: 361.39
MOL File: 603-50-9.mol

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Bisacodyl Property

Melting point:: 138°C
Boiling point:: 493.21°C (rough estimate)
Density: 1.2545 (rough estimate)
refractive index: 1.5614 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids.
pka: 4.69±0.10(Predicted)
color: White to Off-White
Water Solubility: Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
λmax: 220nm(MeOH)(lit.)
Merck: 14,1242
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: KHOITXIGCFIULA-UHFFFAOYSA-N
LogP: 3.453 (est)
CAS DataBase Reference: 603-50-9(CAS DataBase Reference)
NIST Chemistry Reference: Bisacodyl(603-50-9)
EPA Substance Registry System: Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) (603-50-9)

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Safety

Hazard Codes: Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: SM8750000
TSCA: Yes
HS Code: 2933399090
Hazardous Substances Data: 603-50-9(Hazardous Substances Data)
Toxicity: LD50 orally in rats: >3 g/kg (Schmidt)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2794
Product name: Bisacodyl
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 250MG
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP047
Product name: Bisacodyl
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $266
Updated: 2024/03/01

Sigma-Aldrich

Product number: B1390
Product name: Bisacodyl
Purity: analytical standard, for drug analysis
Packaging: 10g
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: B1140000
Product name: Bisacodyl
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: b1140000
Price: $88
Updated: 2024/03/01

TCI Chemical

Product number: B5066
Product name: Bisacodyl
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $76
Updated: 2024/03/01

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Bisacodyl Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Dulcolax,Boehringer Ingelheim,US,1958

Uses

Cathartic.

Uses

Stimulant laxative.

Uses

Bisacodyl is used in the inhibition of (Na+K)ATPase, the increase of mucosal PGE2, and the activation of adenyl cyclase in rat intestine studies. It is used as a laxative drug. It is typically prescribed for relief of constipation.

Definition

ChEBI: Bisacodyl is a diarylmethane.

Manufacturing Process

Preparation of (4,4'-Dihydroxy-Diphenyl)-(Pyridyl-2)-Methane 70.0 grams of α-pyridine aldehyde are fed portionwise with stirring and cooling to a mixture of 200 grams of phenol and 100 cc of concentrated sulfuric acid. The reaction mixture is allowed to stand for a while with repeated stirring, whereby it becomes syrupy, neutralized with sodium carbonate, dissolved in methanol and filtered. The filtrate is introduced into a large quantity of water and the resulting precipitate is recrystallized from a methanol/water mixture. Colorless crystals are obtained of MP 254°C. When using zinc chloride or tin tetrachloride and warming to a temperature of about 50°C, a corresponding result is obtained.
Preparation of Bisacodyl: 5 grams of (4,4'-dihydroxy-diphenyl)-(pyridyl-2)- methane are heated with 5 grams of anhydrous sodium acetate and 20 cc of acetic anhydride for three hours over a boiling water bath. The cooled reaction mixture is poured into water, whereby after a while a colorless substance precipitates, which is filtered off with suction, washed with water and recrystallized from aqueous ethanol. Colorless bright crystals, MP 138°C are obtained.

brand name

Correctol Tablets, Caplets (Schering-Plough HealthCare); Dulcolax (Boehringer Ingelheim); Evac-Q-Tabs (Savage); Feen-a- Mint Tablets (Schering-Plough HealthCare); Modane (Savage); SK-Bisacodyl (SmithKline Beecham); Theralax (SmithKline Beecham).

Therapeutic Function

Laxative

Clinical Use

Laxative

Veterinary Drugs and Treatments

Bisacodyl oral and rectal products are used as stimulant cathartics in dogs and cats.

Metabolism

Bisacodyl is rapidly hydrolysed to the active principle bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), mainly by esterases of the enteric mucosa. After oral and rectal administration, only small amounts of the drug are absorbed and are almost completely conjugated in the intestinal wall and the liver to form the inactive BHPM glucuronide. Following the administration of bisacodyl coated tablets, an average of 51.8% of the dose was recovered in the faeces as free BHPM and an average of 10.5% of the dose was recovered in the urine as BHPM glucuronide. Following the administration as a suppository, an average of 3.1% of the dose was recoveredas BHPM glucuronide in the urine. Stool contained large amounts of BHPM (90% of the total excretion) in addition to small amounts of unchanged bisacodyl

Bisacodyl Preparation Products And Raw materials

Raw materials

2-Picoline Phenol

Preparation Products

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Bisacodyl Suppliers

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View Lastest Price from Bisacodyl manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Bisacodyl 603-50-9
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-03-22

PNP Biotech Co. Ltd

Product: Bisacodyl 603-50-9
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-09-16

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Bisacodyl 603-50-9
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-10-24

603-50-9, BisacodylRelated Search:

Triacetin Glatiramer acetate POLY(VINYL ACETATE) Diphenolic acid Ammonium acetate Sodium acetate 2,4,6-Collidine Ethyl acetate 4-Methylpyridine 5-Chlorovaleric acid Vinyl acetate 2-Chloro-5-chloromethylpyridine Bisphenol A Cellulose acetate 4-(Diethylamino)salicylaldehyde Pralmorelin DL-α-Tocopherol Azamethiphos

2-(4,4’-diacetoxydiphenylmethyl)pyridine

2-(4,4'-Diacetoxydiphenylmethyl)pyridine

4,4'-(2-Pyridylmethylene)diphenol diacetate

4,4'-(2-Pyridylmethylene)diphenol diacetate (ester)

4,4’-(2-pyridinylmethylene)bis-phenodiacetate(ester)

4,4’-(2-pyridylmethylene)di-phenodiacetate(ester)

4,4’-(2-pyridylmethylene)-diphenolacetate

4,4’-(2-Pyridylmethylene)-diphenolace-tate

4,4’-(2-pyridylmethylene)diphenoldiacetate

neolax

nigalax

Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate

Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)

Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate

phenol,4,4’-(2-pyridinylmethylene)bis-,diacetate(ester)

Pyrilax

sanvacual

Sk-bisacodyl

stadalax

telemin

Theralax

BISACODYL

AURORA KA-6302

GENTLAX (PURDUE FREDERICK)

EX-LAX ULTRA (NOVARTIS)

LAXADIN (TEVA)

LABOTEST-BB LT00134695

DULCOLAN (BOEHRINGER, ING)

dulcolax

DULCOLAX (BOEHRINGER, ING)

DUROLAX (BOEHRINGER, ING)

CONTALAX (3M PHARMA)

CORRECTOL (SCHERING-PLOUGH)

STADALAX (STADA)

PERILAX (FERRING)

PYRILAX (BERLIN-CHEMIE)

4,4'-DIACETOXYDIPHENYLPYRIDYL-2-METHANE

[4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate

4,4'-(2-pyridylmethylene)bisphenol diacetate

(4,4’-diacetoxydiphenyl)(2-pyridyl)methane

(4,4'-Diacetoxydiphenyl)(2-pyridyl)methane

4,4’-diacetoxydiphenylpyrid-2-ylmethane

4,4'-Diacetoxydiphenylpyrid-2-ylmethane

4-[[4-(Acetyloxy)phenyl](2-pyridinyl)methyl]phenyl acetate

Bicol

bicosacodyl

Bis(p-acetoxyphenyl)-2-pyridylmethane

brocalax

broxalax

deficol

Di-(4-acetoxyphenyl)-2-pyridylmethane

Di-(p-acetoxyphenyl)-2-pyridylmethane

Dulcolan

durolax

endokolat

eulaxan

fenilaxan

godalax