ChemicalBook > CAS DataBase List > O-Acetyl-L-carnitine hydrochloride

O-Acetyl-L-carnitine hydrochloride

Product Name
O-Acetyl-L-carnitine hydrochloride
CAS No.
5080-50-2
Chemical Name
O-Acetyl-L-carnitine hydrochloride
Synonyms
ACETYL-L-CARNITINE HCL;ALC;ACETYL-L-CARNITINE HYDROCHLORIDE;ALCAR;ACETYL-L-CARNITINE HCI;O-Acetyl-L-carnitine HCl;ACETYL-L-CARNITINE CHLORIDE;Acetyl carnitine Hydrochloride;N-ACETYL-L-CARNITINE HYDROCHLORIDE;ALC HCL
CBNumber
CB5419926
Molecular Formula
C9H18ClNO4
Formula Weight
239.7
MOL File
5080-50-2.mol
More
Less

O-Acetyl-L-carnitine hydrochloride Property

Melting point:
194 °C (dec.)(lit.)
alpha 
-29 º (c=1, H2O)
refractive index 
-28 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
white
optical activity
[α]25/D 28°, c = 2 in H2O(lit.)
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,84
BRN 
4340103
InChI
InChI=1/C9H17NO4.ClH/c1-7(11)14-8(5-9(12)13)6-10(2,3)4;/h8H,5-6H2,1-4H3;1H/t8-;/s3
InChIKey
JATPLOXBFFRHDN-DDWIOCJRSA-N
SMILES
C([N+](C)(C)C)[C@H](OC(=O)C)CC(=O)O.[Cl-] |&1:5,r|
LogP
-4.149 (est)
CAS DataBase Reference
5080-50-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
F 
3-9
HS Code 
29239000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A6706
Product name
O-Acetyl-L-carnitine hydrochloride
Purity
≥99% (titration), powder
Packaging
1g
Price
$54
Updated
2024/03/01
Sigma-Aldrich
Product number
A6706
Product name
O-Acetyl-L-carnitine hydrochloride
Purity
≥99% (titration), powder
Packaging
5g
Price
$177
Updated
2024/03/01
TCI Chemical
Product number
A1394
Product name
Acetyl-L-carnitine Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$89
Updated
2024/03/01
TCI Chemical
Product number
A1394
Product name
Acetyl-L-carnitine Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$269
Updated
2024/03/01
Alfa Aesar
Product number
J61536
Product name
O-Acetyl-L-carnitine hydrochloride
Packaging
5g
Price
$100
Updated
2023/06/20
More
Less

O-Acetyl-L-carnitine hydrochloride Chemical Properties,Usage,Production

Description

Levacecarnine hydrochloride is a nootropic agent structurally related to the natural substance L-carnitine. It is reported to be useful in the treatment of cognition disorders in the elderly, perhaps due to its weak cholinergic properties.

Description

Acetyl-L-carnitine is an acetylated form of the essential mitochondrial metabolite L-carnitine that is catabolized by plasma esterases into carnitine. Acetyl-L-carnitine facilitates the uptake of acetyl-CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. In vivo, acetyl-L-carnitine (100 mg/kg) increases mGlu2/3 receptor protein levels and mechanical pain thresholds in a mouse model of chronic inflammatory pain induced by complete Freund''s adjuvant.

Chemical Properties

Crystallline powder

Originator

Sigma-Tau (Italy)

Uses

O-Acetyl-L-carnitine hydrochloride is used as a cholinergic agonist that stimulates neuronal response to serotonin and acetylcholine. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors.

Uses

Acetyl-L-Carnitine (ALC) is an important dietary supplement. ALC is a natural substance, present in the human body, especially in muscles, in the brain, and in the male testicles. ALC is the acetylated, high-energy form of L-Carnitine.

Uses

O-Acetyl-L-carnitine hydrochloride may be used as a precursor for the preparation of O-Acetyl-L-carnitine, which in turn may be used as an analytical reference standard for the determination of the analyte in biological samples by hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) technique.

brand name

NICETILE; BRANICEN

General Description

Acetyl-L-carnitine (ALC/ALCAR), a quasi-vitamin is a metabolite of carnitine, present in mammalian plasma and tissues. It is the acetylated form of L-carnitine (LC). ALCAR is used as a dietary supplement. It is present at high level in the hypothalamus.

Biochem/physiol Actions

Acetyl L-carnitine (ALC) plays a vital role in intermediary metabolism and in improving female fertility. The oxidative and metabolic status of the female reproductive system is controlled by ALC. ALC possesses cholinomimetic and anti-inflammatory effects. It controls γ-amino butyric acid (GABA) system. ALC is capable of modifying the rate of glucose usage in the brain. It also possesses a neuroprotective role in the developing brain.

in vitro

the expression of tumor antigen ca-125 in ovarian cancer cells was not affected by alcar. comparing to the control, the growth of skov-3 cells was remarkably decreased when incubated with alcar. the proliferation of skov-3 cells was decreased slightly but significantly when cells were incubated at higher alcar concentrations. in addition, alcar had no effect on the expression of the nerve growth factor receptors on skov-3 or ovcar-3 ovarian cancer cells [1].

in vivo

male flinders sensitive line (fsl) rats and male cd1 mice, exposed to model genetic and environmentally induced depression, respectively, were injected intraperitoneally with alcar 100 mg/kg for 21 days. alcar, as a long-lasting and rapid antidepressant, functioned via the epigenetic regulation of type 2 metabotropic glutamate (mglu2) receptors in fsl rats and in mice. additionally, alcar raised the transcription of grm2 gene encoding for the mglu2 receptor via increasing the levels of acetylated h3k27 bound to the grm2 promoter and gaining the acetylation of nf-kb-p65 subunit. [2].

Purification Methods

Recrystallise the chloride from isopropanol. Dry it over P2O5 under high vacuum. The S-betaine crystallises from EtOH/Et2O with m 145o(dec) and is hygroscopic; it has [] D -19.5o (c 6, H2O). [Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al. Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.]

References

[1]. engle, d., belisle, j., gubbels, j., petrie, s., hutson, p., kushner, d., & patankar, m. effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (trk-a and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin. gynecologic oncology. 2009; 112(3): 631-636.
[2]. nasca, c., xenos, d., barone, y., caruso, a., scaccianoce, s., & matrisciano, f. et al. l-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mglu2 receptors. proceedings of the national academy of sciences. 2013; 110(12): 4804-4809.

O-Acetyl-L-carnitine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

O-Acetyl-L-carnitine hydrochloride Suppliers

Americas 1 Belgium 1 Canada 5 China 343 Egypt 1 Europe 3 Germany 4 India 16 Japan 2 South Korea 4 Spain 2 Switzerland 7 United Kingdom 11 United States 52 USA 1 Global 453
Advent Bio, Inc.
Tel
(630) 889-9003
Fax
(630) 889-9021
Email
sales@adventbio.com
Country
United States
ProdList
61
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Creative Enzymes
Tel
1-516-855-7709
Fax
1-631-938-8127
Email
info@creative-enzymes.com
Country
United States
ProdList
8748
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Enzo Life Sciences International Inc.
Tel
--
Fax
--
Email
info-usa@enzolifesciences.com
Country
United States
ProdList
39
Advantage
60
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
Abcam
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6000
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Lalilab, Inc
Tel
--
Fax
--
Email
info@lalilab.com
Country
United States
ProdList
69
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Hexagon Labs
Tel
--
Fax
--
Email
sales@hexagonlabs.com
Country
United States
ProdList
437
Advantage
50
Labseeker Inc
Tel
--
Fax
--
Email
marketing@labseeker.com
Country
United States
ProdList
1495
Advantage
55
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Cambridge Isotope Laboratories, Inc.
Tel
--
Fax
--
Email
cilsales@isotope.com
Country
United States
ProdList
6598
Advantage
79
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
235
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
212
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
LONZA Inc.
Tel
--
Fax
--
Email
contact.allendale@lonza.com
Country
United States
ProdList
252
Advantage
81
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Scandinavian Formulas, Inc.
Tel
--
Fax
--
Email
info@scandinavianformulas.com
Country
United States
ProdList
1447
Advantage
55
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
More
Less

View Lastest Price from O-Acetyl-L-carnitine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Acetyl-L-Carnitine HCl 5080-50-2
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
O-Acetyl-L-carnitine hydrochloride 5080-50-2
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
O-Acetyl-L-carnitine hydrochloride 5080-50-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-26

5080-50-2, O-Acetyl-L-carnitine hydrochlorideRelated Search:

Indole-3-butyric acid Sodium Butyrate Topotecan hydrochloride Potassium chloride Sodium chloride ACETYL-L-CARNITINE Calcium chloride Ammonium chloride Hydrocortisone-17-butyrate Acetyl chloride Acetylacetone L-Carnitine hydrochloride L-Carnitine-L-tartrate Butyric Acid Ferric chloride Acetyl coenzyme A sodium salt Choline chloride Acetoxyacetic acid Acetyl Carnitine Hydrochloride

  • ACETYL-L-CARNITINE HCL(SH)
  • (R)-2-acetoxy-3-carboxy-N,N,N-triMethylpropan-1-aMiniuM chloride
  • O-Acetylcarnitine (hydrochloride)
  • R(-)-2-ACETYLOXY-3-CARBOXYN,N,N-TRIMETHYL1-PROPANAMINIUM CHLORIDE
  • R-(-)-2-ACETYLOXY-3-CARBOXY-N,N,N-TRIMETHYL-1-PROPANAMINIUM HYDROCHLORIDE
  • R-(-)-2-ACETOXY-3-CARBOXY-N,N,N-TRIMETHYL-1-PROPANAMINIUM HYDROCHLORIDE
  • (R)-3-ACETOXY-4-(TRIMETHYLAMMONIO)BUTYRATE HYDROCHLORIDE
  • O-ACETYL-L-CARNITINE CHLORIDE
  • O-ACETYL-L-CARNITINE HYDROCHLORIDE
  • ALC
  • ALCAR
  • ALC HCL
  • ACETYL-L-CARNITINE CHLORIDE
  • ACETYL-L-CARNITINE HCL
  • ACETYL-L-CARNITINE HYDROCHLORIDE
  • 3-O-ACETYL-L-CARNITINE HYDROCHLORIDE
  • 3-ACETYLOXY-4-TRIMETHYLAMMONIO-BUTANOATE HYDROCHLORIDE
  • L-CARNITINE ACETYL ESTER HYDROCHLORIDE
  • L-CARNITINE CHLORIDE, ACETYL-
  • LEVACECARNINE HYDROCHLORIDE
  • L-O-ACETYLCARNITINE CHLORIDE
  • N-Acetyl-L-Carnitine HCl
  • Acetyl carnitine Hydrochloride
  • ACETYL-L-CARNITINE CHLORIDE (L-O-ACETYLC ARNITINE)
  • N-ACETYL-L-CARNITINE HYDROCHLORIDE
  • L-CARNITINE:HCL, O-ACETYL
  • o-Acetyl-L-carnitine hydrochloride, 98% 1GR
  • (S)-3-Acetoxy-4-(triMethylaMMonio)butanoate hydrochloride
  • Acetyl-L-carnitine-d3 HCl
  • ACETYL-L-CARNITINE HCL(P)
  • ALCAR, Acetyl-L-carnitine hydrochlorid
  • -carnitine HydrochL
  • 1-Propanaminium, 2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, chloride, (2R)-
  • ACETYL-1-CARNITINEHYDROCHLORIDE
  • ACETYL-L-CARNITINE HCI
  • 3-O-Acetyl-L-carnitin hydrochlorid
  • Acecarn-HCl
  • L-Carnipure(R) ALC
  • Acetyl-L-carnitine-D3 Cl (N-methyl-D3)
  • (R)-3-Acetoxy-4-(trimetylammino)butyrate hydrochloride
  • (R)-(2-Acetoxy-3-carboxy-propyl)trimethylammonium chloride
  • [(R)-2-Acetoxy-3-carboxypropyl]trimethylaminium·chloride
  • O-Acetyl-L-carnitine HCl
  • o-Acetyl-L-carnitine hydrochloride,98%
  • Acetyl-L-carnitine hydrochloride (factory standard)
  • ALC, ALCAR, (R)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride, (R)-2-Acetyloxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride
  • ALC, ALCAR, R(-)-2-Acetyloxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride, (R)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride
  • L-Acetylcarnitine chloride
  • ALC, ALCAR, (R)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride
  • ACETYL-L-CARNITINE HCL(RG)
  • O-Acetyl-L-carnitine hydrochloride,(R)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride, ALC, ALCAR, R()-2-Acetyloxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride
  • 1-Propanaminium, 2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, chloride (1:1), (2R)-
  • O-Acetyl-L-carnitine hydrochloride 5080-50-2
  • Acetyl-L-carnitine hydrochloride 5080-50-2
  • O-Acetyl-L-carnitine hydrochloride in stock GMP Factory
  • Acetyl-L-carnitine Hydrochloride &gt
  • Acetyl-L-carnitine Hydrochloride, ≥99%
  • (2R)-2-acetyloxy-3-carboxypropyl]-trimethylazanium