2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL

Product Name: 2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL
CAS No.: 39270-39-8
Chemical Name: 2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL
Synonyms: RARECHEM AL BD 0202;1,4-Benzodioxan-6-methanol;3,4-ETHYLENEDIOXYBENZYL ALCOHOL;2,3-dihydro-1,4-benzodioxin-6-methanol;1,4-Benzodioxin-6-methanol,2,3-dihydro-;2,3-Dihydro-1,4-benzodioxan-6-ylmethanol;2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL;(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-Methanol;(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanol;6-(Hydroxymethyl)-2,3-dihydro-1,4-benzodioxin
CBNumber: CB5420027
Molecular Formula: C9H10O3
Formula Weight: 166.17
MOL File: 39270-39-8.mol

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2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL Property

Boiling point:: 129 °C
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.25±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-51-41-37/38
Safety Statements: 26-36/37/39-39
HazardClass: IRRITANT
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D492493
Product name: 2,3-Dihydro-1,4-benzodioxin-6-ylmethanol
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 056478
Product name: 2,3-Dihydro-1,4-benzodioxin-6-ylmethanol
Purity: >95%
Packaging: 500mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H01-1-14
Product name: 2,3-Dihydro-6-(hydroxymethyl)-1,4-benzodioxine
Packaging: 250mg
Price: $77
Updated: 2021/12/16

Matrix Scientific

Product number: 056478
Product name: 2,3-Dihydro-1,4-benzodioxin-6-ylmethanol
Purity: >95%
Packaging: 1g
Price: $100
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H01-1-14
Product name: 2,3-Dihydro-6-(hydroxymethyl)-1,4-benzodioxine
Packaging: 1g
Price: $151
Updated: 2021/12/16

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2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL Chemical Properties,Usage,Production

Synthesis

29668-44-8

39270-39-8

General procedure for the synthesis of benzodioxane-6-methanol from 1,4-benzodioxane-6-carboxaldehyde: 2,3-Dihydro-benzo[1,4]dioxine-6-carboxaldehyde [RN 29668-44-8] (3.04 g, 18.54 mmol) was dissolved in ethanol (100 mL) and the solution was cooled to 0 °C. Sodium borohydride (1.41 g, 37.77 mmol) was added to this solution in batches with stirring. The reaction mixture was continued to be stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched by the slow addition of water (10 mL), followed by concentration under reduced pressure to remove the solvent. The residue was separated by extraction with 5% aqueous sodium bicarbonate (20 mL) and dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using a gradient elution of dichloromethane and methanol. Benzodioxane-6-methanol was finally obtained as a colorless oil (3.00 g, 97% yield).

References

[1] Patent: WO2003/87098, 2003, A1. Location in patent: Page/Page column 43
[2] Patent: WO2010/83246, 2010, A1. Location in patent: Page/Page column 149-150
[3] Australian Journal of Chemistry, 1984, vol. 37, # 4, p. 893 - 901
[4] Chemical Communications (Cambridge, United Kingdom), 2018, vol. 54, # 83, p. 11805 - 11808
[5] Tetrahedron, 2001, vol. 57, # 39, p. 8297 - 8303

2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL Suppliers

Belgium 1 China 73 Germany 3 India 3 United Kingdom 6 United States 11 Global 97

Alchem Pharmtech,Inc.

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SynQuest Laboratories, Inc.

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Matrix Scientific

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Ryan Scientific, Inc.

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Biogene Organics Inc.

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39270-39-8, 2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOLRelated Search:

2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL 1,4-Benzodioxane-6-carboxylic acid Silibinin Isosilybin 2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHANOL 7-AMINO-2,3-DIHYDRO-BENZO[1,4]DIOXINE-6-CARBOXYLIC ACID METHYL ESTER CHEMBRDG-BB 9003902 2-AMINO-1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-ETHANOL 2,3-DIHYDRO-1,4-BENZODIOXIN-5-YLMETHANOL 7-AMINO-2,3-DIHYDRO-BENZO[1,4]DIOXINE-6-CARBOXYLIC ACID 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-ol RARECHEM AL BI 0202 ISOSILANDRIN Silandrin AKOS NCG1-0054 [2-(BENZYLOXY)PHENYL][3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)OXIRAN-2-YL]METHANONE SALOR-INT L122874-1EA 7-NITRO-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBOXYLIC ACID

RARECHEM AL BD 0202

3,4-ETHYLENEDIOXYBENZYL ALCOHOL

2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHANOL

2,3-dihydro-1,4-benzodioxin-6-methanol

6-(Hydroxymethyl)-2,3-dihydro-1,4-benzodioxin

(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanol

2,3-Dihydro-6-(hydroxymethyl)-1,4-benzodioxine

(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-Methanol

1,4-Benzodioxan-6-methanol

1,4-Benzodioxin-6-methanol,2,3-dihydro-

2,3-Dihydro-1,4-benzodioxan-6-ylmethanol

6-(Hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxine

39270-39-8

Benzhydrols, Benzyl & Special Alcohols