5-AMINO-3-METHYL-1,2,4-THIADIAZOLE

Product Name: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE
CAS No.: 17467-35-5
Chemical Name: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE
Synonyms: 3-methyl-1,2,4-thiadiazol-5-amine;TIMTEC-BB SBB005481;5-Amino-3-Methyl-1,2,4-thiadizole;5-Amino-3-Methyl-1,3,4-Thiadiazole;5-AMINO-3-METHYL-1,2,4-THIADIAZOLE;3-METHYL-1,2,4-THIADIAZOL-5-YLAMINE;1,2,4-Thiadiazol-5-amine, 3-methyl-;5-Amino-3-methyl-1,2,4-thiadiazole ,99%;5-aMino-3-Methyl-1,2,4-thiadiazole, 98%+
CBNumber: CB5423134
Molecular Formula: C3H5N3S
Formula Weight: 115.16
MOL File: 17467-35-5.mol

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5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Property

Melting point:: 202 °C
Boiling point:: 261.2±23.0 °C(Predicted)
Density: 1.372±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.56±0.50(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C3H5N3S/c1-2-5-3(4)7-6-2/h1H3,(H2,4,5,6)
InChIKey: DJKUIGPCSNRFRK-UHFFFAOYSA-N
SMILES: S1C(N)=NC(C)=N1
CAS DataBase Reference: 17467-35-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-22
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B485953
Product name: 3-Methyl-1,2,4-thiadiazol-5-amine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 047478
Product name: 3-Methyl-1,2,4-thiadiazol-5-amine
Purity: >95%
Packaging: 5g
Price: $32
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA55393
Product name: 5-Amino-3-methyl-1,2,4-thiadiazole
Packaging: 2g
Price: $70.7
Updated: 2021/12/16

Matrix Scientific

Product number: 047478
Product name: 3-Methyl-1,2,4-thiadiazol-5-amine
Purity: >95%
Packaging: 25g
Price: $98
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H30-1-08
Product name: 5-Amino-3-methyl-1,2,4-thiadiazole
Packaging: 1g
Price: $112
Updated: 2021/12/16

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5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Chemical Properties,Usage,Production

Chemical Properties

prism

Uses

3-methyl-1,2,4-thiadiazol-5-amine is a useful intermediate used in the preparation of 1,2,4-thiadiazole analogue that functions as a non-peptide inhibitor of beta-secretase.

Synthesis

333-20-0

20846-52-0

17467-35-5

The general procedure for the synthesis of 5-amino-3-methyl-1,2,4-thiadiazole from potassium thiocyanate and chloroacetamidine was as follows: chloroacetamidine (5.1 g, 55 mmol) was dissolved in methanol (250 mL) and the resulting solution was cooled to 0 °C. Subsequently, potassium thiocyanate (5.3 g, 55 mmol) was added to the solution. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure, diluted with ethyl acetate (200 mL) and insoluble solids were removed by filtration under reduced pressure. The filtrate was further concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (silica gel, n-hexane:ethyl acetate = 4:1) to afford finally 5-amino-3-methyl-1,2,4-thiadiazole (2 g, 32% yield). The structure of the product was confirmed by 1H NMR (600 MHz, CD3OD), δ 3.27 (s, 3H).

References

[1] Patent: US2012/264727, 2012, A1. Location in patent: Page/Page column 53
[2] Patent: EP2706062, 2014, A2. Location in patent: Paragraph 0199

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Suppliers

China 132 Europe 2 France 1 Germany 2 India 6 The Netherlands 1 United Kingdom 13 United States 21 Global 178

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View Lastest Price from 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Amino-3-methyl-1,2,4-thiadiazole 17467-35-5
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Shaanxi Dideu New Materials Co. Ltd

Product: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE 17467-35-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-04-24

Career Henan Chemical Co

Product: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE 17467-35-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-17

17467-35-5, 5-AMINO-3-METHYL-1,2,4-THIADIAZOLERelated Search:

5-AMINO-3-PHENYL-1,2,4-THIADIAZOLE 5-AMINO-3-ETHYL-1,2,4-THIADIAZOLE 5-Hydrazino-3-(2-thienyl)-1,2,4-thiadiazole Cefozopran 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE 3-PHENYL-5-PIPERAZINO-1,2,4-THIADIAZOLE 1-(5-METHYLAMINO-[1,2,4]THIADIAZOL-3-YL)-PROPAN-2-ONE JNJ 1661010 5-AMINO-3-ISOPROPYL-1,2,4-THIADIAZOLE 3-Amino-5-methyl-1,2,4-thiadiazole 2-AMINO-5-METHYL-1,3,4-THIADIAZOLE,2-AMINO-5-METHYL-1,3,4-THIADIAZOLE 97% Cefclidin 5-(1,4-DIAZEPAN-1-YL)-3-PHENYL-1,2,4-THIADIAZOLE 3-(Trichloromethyl)1,2,4-thiadiazol-5-amine Cefluprenam 2-(4-CARBOXYBUTYRYL)AMINO-5-METHYL-1,3,4-THIADIAZOLE N,3-DIPHENYL-1,2,4-THIADIAZOL-5-AMINE 1-(5-ANILINO-1,2,4-THIADIAZOL-3-YL)ACETONE

TIMTEC-BB SBB005481

5-Amino-3-Methyl-1,3,4-Thiadiazole

3-METHYL-1,2,4-THIADIAZOL-5-YLAMINE

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE

1,2,4-Thiadiazol-5-amine, 3-methyl-

5-Amino-3-methyl-1,2,4-thiadiazole ,99%

5-aMino-3-Methyl-1,2,4-thiadiazole, 98%+

3-methyl-1,2,4-thiadiazol-5-amine

5-Amino-3-Methyl-1,2,4-thiadizole

17467-35-5

C3H5N3S

Heterocyclic Compounds

Thiadiazol

Amines