2-Amino-5-methyl-1,3,4-thiadiazole

Product Name: 2-Amino-5-methyl-1,3,4-thiadiazole
CAS No.: 108-33-8
Chemical Name: 2-Amino-5-methyl-1,3,4-thiadiazole
Synonyms: 5-METHYL-1,3,4-THIADIAZOL-2-AMINE;5-methyl-1,3,4-thiadiazole-2-amine;usafcy-3;TOSLAB 27625;AKOS BBS-00007966;VITAS-BB TBB000116;TIMTEC-BB SBB000045;2-AMINO-5-METHYLTHIADIAZOLE;4-thiadiazol-2-amine,5-methyl-3;4-thiadiazole,2-amino-5-methyl-3
CBNumber: CB1676271
Molecular Formula: C3H5N3S
Formula Weight: 115.16
MOL File: 108-33-8.mol

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2-Amino-5-methyl-1,3,4-thiadiazole Property

Melting point:: 223-228 °C
Boiling point:: 261.2±23.0 °C(Predicted)
Density: 1.287 (estimate)
refractive index: 1.5800 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Sparingly), Methanol (Slightly)
form: solid
pka: 3.84±0.10(Predicted)
color: Off-White
InChI: InChI=1S/C3H5N3S/c1-2-5-6-3(4)7-2/h1H3,(H2,4,6)
InChIKey: HMPUHXCGUHDVBI-UHFFFAOYSA-N
SMILES: S1C(C)=NN=C1N
CAS DataBase Reference: 108-33-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-37/39-26
WGK Germany: 3
RTECS: XI3500000
Hazard Note: Irritant
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 686166
Product name: 2-Amino-5-methyl-1,3,4-thiadiazole
Purity: 97%
Packaging: 5g
Price: $44.31
Updated: 2025/07/31

TCI Chemical

Product number: A0874
Product name: 2-Amino-5-methyl-1,3,4-thiadiazole
Purity: >98.0%(T)
Packaging: 5g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: A0874
Product name: 2-Amino-5-methyl-1,3,4-thiadiazole
Purity: >98.0%(T)
Packaging: 25g
Price: $169
Updated: 2025/07/31

TRC

Product number: A617080
Product name: 2-Amino-5-methyl-1,3,4-thiadiazole
Packaging: 50g
Price: $325
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA34351
Product name: 2-Amino-5-methyl-1,3,4-thiadiazole
Packaging: 250g
Price: $500
Updated: 2021/12/16

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2-Amino-5-methyl-1,3,4-thiadiazole Chemical Properties,Usage,Production

Chemical Properties

White to light beige crystalline powder

Uses

2-Amino-5-methyl-1,3,4-thiadiazole was used as a reagent in the synthesis of substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones which diplayed good cytotoxic activities. Also used in the design of new phenothiazine-thiadiazole hybrids for development of antitubercular agents.

Definition

ChEBI: 5-Methyl-1,3,4-thiadiazol-2-amine is a member of thiadiazoles.

Synthesis

64-19-7

79-19-6

108-33-8

1) 0.05 mol of aminothiourea was added to a dry mortar, followed by 0.055 mol of glacial acetic acid, 0.055 mol of silica, and 0.25 mol of phosphorus trichloride, and ground for 10 min at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) using a solvent mixture of ethyl acetate and petroleum ether in the ratio of 1:3 by volume as the unfolding agent until the point of raw material aminothiourea disappeared, indicating that the reaction was complete. The crude product was obtained after standing for 30 min.2) The crude product was transferred to a beaker and the pH was adjusted to 8 by adding 5% sodium carbonate solution.The mixture was withdrawn and filtered and the filter cake was dissolved with N,N-dimethylformamide (DMF) to remove silica gel. The filtrate was concentrated under reduced pressure, and after removing the solvent, washed with water and filtered by suction to afford 2-amino-5-methyl-1,3,4-thiadiazole in 95.2% yield.

References

[1] Patent: CN103880776, 2016, B. Location in patent: Paragraph 0024-0026
[2] Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 2, p. 637 - 638
[3] Synthetic Communications, 2000, vol. 30, # 16, p. 3031 - 3040
[4] Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 1, p. 115 - 121
[5] Journal of Chemical Research, 2005, # 5, p. 341 - 343

2-Amino-5-methyl-1,3,4-thiadiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-methyl-1,3,4-thiadiazole Suppliers

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View Lastest Price from 2-Amino-5-methyl-1,3,4-thiadiazole manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Henan Fengda Chemical Co., Ltd

Product: 2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
Price: US $6.00-0.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-24

Career Henan Chemical Co

Product: 2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10MT
Release date: 2018-12-21

108-33-8, 2-Amino-5-methyl-1,3,4-thiadiazoleRelated Search:

EC 2.6.1.2 Methyl salicylate Tribenuron methyl Methyl acetate Acetaminophen 2-Mercapto-5-methyl-1,3,4-thiadiazole 2,1,3-Benzothiadiazole Kresoxim-methyl N-Ethylmethylamine 2-Amino-1,3,4-thiadiazole Pirimiphos-methyl METSULFURON METHYL N,N-Dimethyl-1,4-phenylenediamine Thiophanate-methyl Tris(hydroxymethyl)aminomethane Methyl 4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Methyl bromide

TIMTEC-BB SBB000045

VITAS-BB TBB000116

TOSLAB 27625

4-thiadiazol-2-amine,5-methyl-3

4-thiadiazole,2-amino-5-methyl-3

5-methyl-1,3,4-thiadiazole-2-amine

usafcy-3

1,3,4-Thiadiazole, 2-amino-5-methyl.

5-methyl-2-amino-1,3,4-thiadiazole

2-AMINO-5-METHYL-1,3,4-THIADIAZOLE 97%

2-AMINO-5-METHYL-1,3,4-THIADIZOLE

5-METHYL-1,3,4-THIADIAZOL-2-AMINE

5-METHYL-[1,3,4]THIADIAZOL-2-YLAMINE

AKOS BBS-00007966

2-AMINO-5-METHYL-1,3,4-THIADIAZOLE

2-AMINO-5-METHYLTHIADIAZOLE

2-AMino-5-Methyl-1,3,4-thiadiazole, 97% 5GR

1,3,4-Thiadiazol-2-amine, 5-methyl

2-Amino-5-methyl-1,3,4-thiadiazole,97%

2-Amino-5-methyl-1,3,4-thiadiazole &gt

2-Amino-5-jnethyl-l, 3, 4-thiadi azole

108-33-8

1456-57-9

Amines

Oxadiazoles & Thiadiazoles

API intermediates

Oxadiazoles & Thiadiazoles

Building Blocks

Heterocyclic Building Blocks

Thiadiazoles