2-Amino-5-methyl-1,3,4-thiadiazole
- Product Name
- 2-Amino-5-methyl-1,3,4-thiadiazole
- CAS No.
- 108-33-8
- Chemical Name
- 2-Amino-5-methyl-1,3,4-thiadiazole
- Synonyms
- 5-METHYL-1,3,4-THIADIAZOL-2-AMINE;5-methyl-1,3,4-thiadiazole-2-amine;usafcy-3;TOSLAB 27625;AKOS BBS-00007966;VITAS-BB TBB000116;TIMTEC-BB SBB000045;2-AMINO-5-METHYLTHIADIAZOLE;4-thiadiazol-2-amine,5-methyl-3;4-thiadiazole,2-amino-5-methyl-3
- CBNumber
- CB1676271
- Molecular Formula
- C3H5N3S
- Formula Weight
- 115.16
- MOL File
- 108-33-8.mol
2-Amino-5-methyl-1,3,4-thiadiazole Property
- Melting point:
- 223-228 °C
- Boiling point:
- 261.2±23.0 °C(Predicted)
- Density
- 1.287 (estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- solid
- pka
- 3.84±0.10(Predicted)
- color
- Off-White
- InChI
- InChI=1S/C3H5N3S/c1-2-5-6-3(4)7-2/h1H3,(H2,4,6)
- InChIKey
- HMPUHXCGUHDVBI-UHFFFAOYSA-N
- SMILES
- S1C(C)=NN=C1N
- CAS DataBase Reference
- 108-33-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-37/39-26
- WGK Germany
- 3
- RTECS
- XI3500000
- Hazard Note
- Irritant
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 686166
- Product name
- 2-Amino-5-methyl-1,3,4-thiadiazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $44.31
- Updated
- 2025/07/31
- Product number
- A0874
- Product name
- 2-Amino-5-methyl-1,3,4-thiadiazole
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- A0874
- Product name
- 2-Amino-5-methyl-1,3,4-thiadiazole
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $169
- Updated
- 2025/07/31
- Product number
- A617080
- Product name
- 2-Amino-5-methyl-1,3,4-thiadiazole
- Packaging
- 50g
- Price
- $325
- Updated
- 2021/12/16
- Product number
- 013407
- Product name
- 2-Amino-5-methyl-1,3,4-thiadiazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2-Amino-5-methyl-1,3,4-thiadiazole Chemical Properties,Usage,Production
Chemical Properties
White to light beige crystalline powder
Uses
2-Amino-5-methyl-1,3,4-thiadiazole was used as a reagent in the synthesis of substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones which diplayed good cytotoxic activities. Also used in the design of new phenothiazine-thiadiazole hybrids for development of antitubercular agents.
Definition
ChEBI: 5-Methyl-1,3,4-thiadiazol-2-amine is a member of thiadiazoles.
Synthesis
64-19-7
79-19-6
108-33-8
1) 0.05 mol of aminothiourea was added to a dry mortar, followed by 0.055 mol of glacial acetic acid, 0.055 mol of silica, and 0.25 mol of phosphorus trichloride, and ground for 10 min at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) using a solvent mixture of ethyl acetate and petroleum ether in the ratio of 1:3 by volume as the unfolding agent until the point of raw material aminothiourea disappeared, indicating that the reaction was complete. The crude product was obtained after standing for 30 min.2) The crude product was transferred to a beaker and the pH was adjusted to 8 by adding 5% sodium carbonate solution.The mixture was withdrawn and filtered and the filter cake was dissolved with N,N-dimethylformamide (DMF) to remove silica gel. The filtrate was concentrated under reduced pressure, and after removing the solvent, washed with water and filtered by suction to afford 2-amino-5-methyl-1,3,4-thiadiazole in 95.2% yield.
References
[1] Patent: CN103880776, 2016, B. Location in patent: Paragraph 0024-0026
[2] Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 2, p. 637 - 638
[3] Synthetic Communications, 2000, vol. 30, # 16, p. 3031 - 3040
[4] Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 1, p. 115 - 121
[5] Journal of Chemical Research, 2005, # 5, p. 341 - 343
2-Amino-5-methyl-1,3,4-thiadiazole Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-5-methyl-1,3,4-thiadiazole Suppliers
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View Lastest Price from 2-Amino-5-methyl-1,3,4-thiadiazole manufacturers
- Product
- 2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
- Price
- US $6.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-24
- Product
- 2-Amino-5-methyl-1,3,4-thiadiazole 108-33-8
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10MT
- Release date
- 2018-12-21